Genome of the Chinese tree shrew View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Yu Fan, Zhi-Yong Huang, Chang-Chang Cao, Ce-Shi Chen, Yuan-Xin Chen, Ding-Ding Fan, Jing He, Hao-Long Hou, Li Hu, Xin-Tian Hu, Xuan-Ting Jiang, Ren Lai, Yong-Shan Lang, Bin Liang, Sheng-Guang Liao, Dan Mu, Yuan-Ye Ma, Yu-Yu Niu, Xiao-Qing Sun, Jin-Quan Xia, Jin Xiao, Zhi-Qiang Xiong, Lin Xu, Lan Yang, Yun Zhang, Wei Zhao, Xu-Dong Zhao, Yong-Tang Zheng, Ju-Min Zhou, Ya-Bing Zhu, Guo-Jie Zhang, Jun Wang, Yong-Gang Yao

ABSTRACT

Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as models for a variety of human disorders: depression, myopia, hepatitis B and C virus infections, and hepatocellular carcinoma, to name a few. Here we present a publicly available annotated genome sequence for the Chinese tree shrew. Phylogenomic analysis of the tree shrew and other mammalians highly support its close affinity to primates. By characterizing key factors and signalling pathways in nervous and immune systems, we demonstrate that tree shrews possess both shared common and unique features, and provide a genetic basis for the use of this animal as a potential model for biomedical research. More... »

PAGES

1426

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms2416

    DOI

    http://dx.doi.org/10.1038/ncomms2416

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005761175

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23385571


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