A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-01-22

AUTHORS

Fumihiko Maekawa, Miyano Sakurai, Yuki Yamashita, Kohichi Tanaka, Shogo Haraguchi, Kazutoshi Yamamoto, Kazuyoshi Tsutsui, Hidefumi Yoshioka, Shizuko Murakami, Ryo Tadano, Tatsuhiko Goto, Jun-ichi Shiraishi, Kohei Tomonari, Takao Oka, Ken Ohara, Teruo Maeda, Takashi Bungo, Masaoki Tsudzuki, Hiroko Ohki-Hamazaki

ABSTRACT

Sexual differentiation leads to structural and behavioural differences between males and females. Here we investigate the intrinsic sex identity of the brain by constructing chicken chimeras in which the brain primordium is switched between male and female identities before gonadal development. We find that the female chimeras with male brains display delayed sexual maturation and irregular oviposition cycles, although their behaviour, plasma concentrations of sex steroids and luteinizing hormone levels are normal. The male chimeras with female brains show phenotypes similar to typical cocks. In the perinatal period, oestrogen concentrations in the genetically male brain are higher than those in the genetically female brain. Our study demonstrates that male brain cells retain male sex identity and do not differentiate into female cells to drive the normal oestrous cycle, even when situated in the female hormonal milieu. This is clear evidence for a sex-specific feature that develops independent of gonadal steroids. More... »

PAGES

1372

References to SciGraph publications

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  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    4

    Author Affiliations

  • Molecular Toxicology Section, Center for Environmental Health Sciences, National Institute for Environmental Studies, Onogawa, Tsukuba, 305-8506, Ibaraki, Japan
  • Division of Biology, College of Liberal Arts and Sciences, Kitasato University, Kitazato, Minami-ku, Sagamihara, 252-0373, Kanagawa, Japan
  • Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, 113-8510, Tokyo, Japan
  • Department of Biology and Center for Medical Life Science, Laboratory of Integrative Brain Sciences, Waseda University, Wakamatsu-cho, Shinjuku-ku, 162-8480, Tokyo, Japan
  • Department of Natural Sciences, Hyogo University of Teacher Education, Shimokume, Katoh, 673-1494, Hyogo, Japan
  • Department of Cell Biology and Neuroscience, Juntendo University School of Medicine, Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan
  • Present address: Faculty of Applied Biological Sciences, Department of Agricultural Science, Laboratory of Animal Genome Diversity, Gifu University, Yanagido, Gifu 501-1193, Japan
  • Present address: Mouse Genomics Resource Laboratory, Research Organization of Information and Systems, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan
  • Present address: Department of Animal Science, Nippon Veterinary and Life Science University, Kyonan-cho, Musashino, Tokyo 180-8602, Japan
  • Laboratory of Animal Breeding and Genetics, Graduate School of Biosphere Science, Hiroshima University, Kagamiyama, Higashi-Hiroshima, 739-8528, Hiroshima, Japan
  • Japanese Avian Bioresource Project Research Center, Hiroshima University, Kagamiyama, Higashi-Hiroshima, 739-8528, Hiroshima, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms2372

    DOI

    http://dx.doi.org/10.1038/ncomms2372

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014758743

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23340412


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