Switching of myosin-V motion between the lever-arm swing and Brownian search-and-catch View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01

AUTHORS

Keisuke Fujita, Mitsuhiro Iwaki, Atsuko H. Iwane, Lorenzo Marcucci, Toshio Yanagida

ABSTRACT

Motor proteins are force-generating nanomachines that are highly adaptable to their ever-changing biological environments and have a high energy conversion efficiency. Here we constructed an imaging system that uses optical tweezers and a DNA handle to visualize elementary mechanical processes of a nanomachine under load. We apply our system to myosin-V, a well-known motor protein that takes 72 nm 'hand-over-hand' steps composed of a 'lever-arm swing' and a 'Brownian search-and-catch'. We find that the lever-arm swing generates a large proportion of the force at low load (<0.5 pN), resulting in 3 kBT of work. At high load (1.9 pN), however, the contribution of the Brownian search-and-catch increases to dominate, reaching 13 kBT of work. We believe the ability to switch between these two force-generation modes facilitates myosin-V function at high efficiency while operating in a dynamic intracellular environment. More... »

PAGES

956

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms1934

DOI

http://dx.doi.org/10.1038/ncomms1934

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038655609

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22805563


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