Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01

AUTHORS

Frances P. Noonan, M. Raza Zaidi, Agnieszka Wolnicka-Glubisz, Miriam R. Anver, Jesse Bahn, Albert Wielgus, Jean Cadet, Thierry Douki, Stephane Mouret, Margaret A. Tucker, Anastas Popratiloff, Glenn Merlino, Edward C. De Fabo

ABSTRACT

Malignant melanoma of the skin (CMM) is associated with ultraviolet radiation exposure, but the mechanisms and even the wavelengths responsible are unclear. Here we use a mammalian model to investigate melanoma formed in response to precise spectrally defined ultraviolet wavelengths and biologically relevant doses. We show that melanoma induction by ultraviolet A (320–400 nm) requires the presence of melanin pigment and is associated with oxidative DNA damage within melanocytes. In contrast, ultraviolet B radiation (280–320 nm) initiates melanoma in a pigment-independent manner associated with direct ultraviolet B DNA damage. Thus, we identified two ultraviolet wavelength-dependent pathways for the induction of CMM and describe an unexpected and significant role for melanin within the melanocyte in melanomagenesis. More... »

PAGES

884

Journal

TITLE

Nature Communications

ISSUE

1

VOLUME

3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms1893

DOI

http://dx.doi.org/10.1038/ncomms1893

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029449177

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22673911


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30 schema:description Malignant melanoma of the skin (CMM) is associated with ultraviolet radiation exposure, but the mechanisms and even the wavelengths responsible are unclear. Here we use a mammalian model to investigate melanoma formed in response to precise spectrally defined ultraviolet wavelengths and biologically relevant doses. We show that melanoma induction by ultraviolet A (320–400 nm) requires the presence of melanin pigment and is associated with oxidative DNA damage within melanocytes. In contrast, ultraviolet B radiation (280–320 nm) initiates melanoma in a pigment-independent manner associated with direct ultraviolet B DNA damage. Thus, we identified two ultraviolet wavelength-dependent pathways for the induction of CMM and describe an unexpected and significant role for melanin within the melanocyte in melanomagenesis.
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