Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07-17

AUTHORS

Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar

ABSTRACT

The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have developed a novel method that rapidly screens multiple proteins in parallel using DNA-encoded library technology (ELT). Initial efforts were focused on the efficient discovery of antibacterial leads against 119 targets from Acinetobacter baumannii and Staphylococcus aureus. The success of this effort led to the hypothesis that the relative number of ELT binders alone could be used to assess the ligandability of large sets of proteins. This concept was further explored by screening 42 targets from Mycobacterium tuberculosis. Active chemical series for six targets from our initial effort as well as three chemotypes for DHFR from M. tuberculosis are reported. The findings demonstrate that parallel ELT selections can be used to assess ligandability and highlight opportunities for successful lead and tool discovery. More... »

PAGES

16081

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms16081

DOI

http://dx.doi.org/10.1038/ncomms16081

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090738829

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28714473


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Machutta", 
        "givenName": "Carl A.", 
        "id": "sg:person.01215035002.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215035002.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kollmann", 
        "givenName": "Christopher S.", 
        "id": "sg:person.0642342504.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642342504.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lind", 
        "givenName": "Kenneth E.", 
        "id": "sg:person.01023777603.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023777603.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bai", 
        "givenName": "Xiaopeng", 
        "id": "sg:person.0710455704.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710455704.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chan", 
        "givenName": "Pan F.", 
        "id": "sg:person.01162123151.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162123151.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Jianzhong", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (Spain)", 
          "id": "https://www.grid.ac/institutes/grid.419327.a", 
          "name": [
            "GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ballell", 
        "givenName": "Lluis", 
        "id": "sg:person.0703716354.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703716354.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belyanskaya", 
        "givenName": "Svetlana", 
        "id": "sg:person.01260621143.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260621143.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "University of Birmingham, School of Biosciences, Edgbaston, Birmingham B15 2TT, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Besra", 
        "givenName": "Gurdyal S.", 
        "id": "sg:person.012366545337.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012366545337.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (Spain)", 
          "id": "https://www.grid.ac/institutes/grid.419327.a", 
          "name": [
            "GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barros-Aguirre", 
        "givenName": "David", 
        "id": "sg:person.01022102260.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022102260.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (Spain)", 
          "id": "https://www.grid.ac/institutes/grid.419327.a", 
          "name": [
            "GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bates", 
        "givenName": "Robert H.", 
        "id": "sg:person.01343134030.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343134030.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Centrella", 
        "givenName": "Paolo A.", 
        "id": "sg:person.0713715543.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713715543.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Sandy S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chai", 
        "givenName": "Jing", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choudhry", 
        "givenName": "Anthony E.", 
        "id": "sg:person.01271252451.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271252451.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coffin", 
        "givenName": "Aaron", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davie", 
        "givenName": "Christopher P.", 
        "id": "sg:person.016565045243.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016565045243.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deng", 
        "givenName": "Hongfeng", 
        "id": "sg:person.0762114156.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762114156.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deng", 
        "givenName": "Jianghe", 
        "id": "sg:person.0755747522.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755747522.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ding", 
        "givenName": "Yun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dodson", 
        "givenName": "Jason W.", 
        "id": "sg:person.0666763731.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666763731.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fosbenner", 
        "givenName": "David T.", 
        "id": "sg:person.011303627613.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011303627613.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gao", 
        "givenName": "Enoch N.", 
        "id": "sg:person.0761312310.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761312310.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graham", 
        "givenName": "Taylor L.", 
        "id": "sg:person.0745347373.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745347373.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graybill", 
        "givenName": "Todd L.", 
        "id": "sg:person.0577667173.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577667173.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ingraham", 
        "givenName": "Karen", 
        "id": "sg:person.01147351106.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147351106.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnson", 
        "givenName": "Walter P.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "King", 
        "givenName": "Bryan W.", 
        "id": "sg:person.012067157062.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012067157062.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwiatkowski", 
        "givenName": "Christopher R.", 
        "id": "sg:person.016462053213.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016462053213.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (Spain)", 
          "id": "https://www.grid.ac/institutes/grid.419327.a", 
          "name": [
            "GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leli\u00e8vre", 
        "givenName": "Jo\u00ebl", 
        "id": "sg:person.0772407262.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772407262.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Yue", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Xiaorong", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Quinn", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lehr", 
        "givenName": "Ruth", 
        "id": "sg:person.0723272577.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723272577.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (Spain)", 
          "id": "https://www.grid.ac/institutes/grid.419327.a", 
          "name": [
            "GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mendoza-Losana", 
        "givenName": "Alfonso", 
        "id": "sg:person.0602571422.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602571422.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martin", 
        "givenName": "John", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McCloskey", 
        "givenName": "Lynn", 
        "id": "sg:person.01214022621.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214022621.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McCormick", 
        "givenName": "Patti", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Keefe", 
        "givenName": "Heather P.", 
        "id": "sg:person.0707551203.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707551203.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Keeffe", 
        "givenName": "Thomas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pao", 
        "givenName": "Christina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Phelps", 
        "givenName": "Christopher B.", 
        "id": "sg:person.012771744767.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012771744767.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qi", 
        "givenName": "Hongwei", 
        "id": "sg:person.01253630520.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253630520.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rafferty", 
        "givenName": "Keith", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scavello", 
        "givenName": "Genaro S.", 
        "id": "sg:person.0703605542.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703605542.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steiginga", 
        "givenName": "Matt S.", 
        "id": "sg:person.014405760213.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014405760213.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sundersingh", 
        "givenName": "Flora S.", 
        "id": "sg:person.01122622201.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122622201.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sweitzer", 
        "givenName": "Sharon M.", 
        "id": "sg:person.01062651353.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062651353.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szewczuk", 
        "givenName": "Lawrence M.", 
        "id": "sg:person.0735405665.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735405665.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "Amy", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toh", 
        "givenName": "May Fern", 
        "id": "sg:person.01330713325.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330713325.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Juan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Minghui", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilkins", 
        "givenName": "Devan J.", 
        "id": "sg:person.013061132413.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013061132413.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xia", 
        "givenName": "Bing", 
        "id": "sg:person.0633252512.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633252512.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yao", 
        "givenName": "Gang", 
        "id": "sg:person.01320347222.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320347222.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jean", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Jingye", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Donahue", 
        "givenName": "Christine P.", 
        "id": "sg:person.01052545614.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052545614.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Messer", 
        "givenName": "Jeffrey A.", 
        "id": "sg:person.01073063147.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073063147.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holmes", 
        "givenName": "David", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arico-Muendel", 
        "givenName": "Christopher C.", 
        "id": "sg:person.0765672043.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765672043.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pope", 
        "givenName": "Andrew J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gross", 
        "givenName": "Jeffrey W.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Evindar", 
        "givenName": "Ghotas", 
        "id": "sg:person.01312001745.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312001745.40"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1021/acsmedchemlett.5b00179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000098905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201410736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000671106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drudis.2011.02.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002389259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd4783", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002982107", 
          "https://doi.org/10.1038/nrd4783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drudis.2016.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004553457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm300449x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005047465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd.2016.213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005381791", 
          "https://doi.org/10.1038/nrd.2016.213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd3701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005505350", 
          "https://doi.org/10.1038/nrd3701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005793977", 
          "https://doi.org/10.1038/nrd2201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005793977", 
          "https://doi.org/10.1038/nrd2201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.1427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006324154", 
          "https://doi.org/10.1038/nchembio.1427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/co5001037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006767278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c1cs15076f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006980820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6446(05)03624-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008182859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja808558a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009313128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja808558a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009313128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2014.01.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009934162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/17460441.3.4.391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010675663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1610978113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011079427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.1429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012221959", 
          "https://doi.org/10.1038/nchembio.1429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0077142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012425551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cb400896g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015816593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbic.201600567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016377022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acschembio.5b00981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016737567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbic.201600660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018754194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2016.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019024909", 
          "https://doi.org/10.1038/nprot.2016.039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6446(05)03666-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021100332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cmdc.201300429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021942218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022121817", 
          "https://doi.org/10.1038/nchembio.211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022121817", 
          "https://doi.org/10.1038/nchembio.211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm400204k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024940714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.2002.02832.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025056780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156802611795429130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026287292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201612143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026368502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2013.04.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028752832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acsmedchemlett.5b00025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031954610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2014.0086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034345147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd4650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034610869", 
          "https://doi.org/10.1038/nrd4650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd3681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035163834", 
          "https://doi.org/10.1038/nrd3681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/530367a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035213550", 
          "https://doi.org/10.1038/530367a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00894-010-0683-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035307573", 
          "https://doi.org/10.1007/s00894-010-0683-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00894-010-0683-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035307573", 
          "https://doi.org/10.1007/s00894-010-0683-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbic.201600573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035348169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035924874", 
          "https://doi.org/10.1038/nbt961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035924874", 
          "https://doi.org/10.1038/nbt961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature17042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038585164", 
          "https://doi.org/10.1038/nature17042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja015873n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039619647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja015873n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039619647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c5cc01230a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039619879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.12.5381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041627906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.00834-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042206726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm401326j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044824154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/470163a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045497536", 
          "https://doi.org/10.1038/470163a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.1867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046035901", 
          "https://doi.org/10.1038/nchembio.1867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1087057116637353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046325437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1087057116637353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046325437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio0708-382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048495800", 
          "https://doi.org/10.1038/nchembio0708-382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2012.01.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048912243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.bioconjchem.5b00239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055081985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jmedchem.6b00746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055100231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jmedchem.6b00746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055100231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ci200613b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055402859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm049131r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055948902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm049131r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055948902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156802607780059781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069193470"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-07-17", 
    "datePublishedReg": "2017-07-17", 
    "description": "The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have developed a novel method that rapidly screens multiple proteins in parallel using DNA-encoded library technology (ELT). Initial efforts were focused on the efficient discovery of antibacterial leads against 119 targets from Acinetobacter baumannii and Staphylococcus aureus. The success of this effort led to the hypothesis that the relative number of ELT binders alone could be used to assess the ligandability of large sets of proteins. This concept was further explored by screening 42 targets from Mycobacterium tuberculosis. Active chemical series for six targets from our initial effort as well as three chemotypes for DHFR from M. tuberculosis are reported. The findings demonstrate that parallel ELT selections can be used to assess ligandability and highlight opportunities for successful lead and tool discovery.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms16081", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening", 
    "pagination": "16081", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4274490798b830df6162f948f30ba72901b794ef0d72f6627a0392d24e0a2e5d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28714473"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms16081"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1090738829"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms16081", 
      "https://app.dimensions.ai/details/publication/pub.1090738829"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000608.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms16081"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms16081'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms16081'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms16081'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms16081'


 

This table displays all metadata directly associated to this object as RDF triples.

683 TRIPLES      21 PREDICATES      83 URIs      19 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms16081 schema:about anzsrc-for:11
2 anzsrc-for:1108
3 schema:author N814da045c2914a489ec1059b0cc19601
4 schema:citation sg:pub.10.1007/s00894-010-0683-y
5 sg:pub.10.1038/470163a
6 sg:pub.10.1038/530367a
7 sg:pub.10.1038/nature17042
8 sg:pub.10.1038/nbt961
9 sg:pub.10.1038/nchembio.1427
10 sg:pub.10.1038/nchembio.1429
11 sg:pub.10.1038/nchembio.1867
12 sg:pub.10.1038/nchembio.211
13 sg:pub.10.1038/nchembio0708-382
14 sg:pub.10.1038/nprot.2016.039
15 sg:pub.10.1038/nrd.2016.213
16 sg:pub.10.1038/nrd2201
17 sg:pub.10.1038/nrd3681
18 sg:pub.10.1038/nrd3701
19 sg:pub.10.1038/nrd4650
20 sg:pub.10.1038/nrd4783
21 https://doi.org/10.1002/anie.201410736
22 https://doi.org/10.1002/anie.201612143
23 https://doi.org/10.1002/cbic.201600567
24 https://doi.org/10.1002/cbic.201600573
25 https://doi.org/10.1002/cbic.201600660
26 https://doi.org/10.1002/cmdc.201300429
27 https://doi.org/10.1016/j.bmc.2014.01.050
28 https://doi.org/10.1016/j.bmcl.2012.01.034
29 https://doi.org/10.1016/j.bmcl.2013.04.019
30 https://doi.org/10.1016/j.drudis.2011.02.002
31 https://doi.org/10.1016/j.drudis.2016.07.007
32 https://doi.org/10.1016/s1359-6446(05)03624-x
33 https://doi.org/10.1016/s1359-6446(05)03666-4
34 https://doi.org/10.1021/acs.bioconjchem.5b00239
35 https://doi.org/10.1021/acs.jmedchem.6b00746
36 https://doi.org/10.1021/acschembio.5b00981
37 https://doi.org/10.1021/acsmedchemlett.5b00025
38 https://doi.org/10.1021/acsmedchemlett.5b00179
39 https://doi.org/10.1021/cb400896g
40 https://doi.org/10.1021/ci200613b
41 https://doi.org/10.1021/co5001037
42 https://doi.org/10.1021/ja015873n
43 https://doi.org/10.1021/ja808558a
44 https://doi.org/10.1021/jm049131r
45 https://doi.org/10.1021/jm300449x
46 https://doi.org/10.1021/jm400204k
47 https://doi.org/10.1021/jm401326j
48 https://doi.org/10.1039/c1cs15076f
49 https://doi.org/10.1039/c5cc01230a
50 https://doi.org/10.1046/j.1365-2958.2002.02832.x
51 https://doi.org/10.1073/pnas.1610978113
52 https://doi.org/10.1073/pnas.89.12.5381
53 https://doi.org/10.1098/rstb.2014.0086
54 https://doi.org/10.1128/aac.00834-10
55 https://doi.org/10.1177/1087057116637353
56 https://doi.org/10.1371/journal.pone.0077142
57 https://doi.org/10.1517/17460441.3.4.391
58 https://doi.org/10.2174/156802607780059781
59 https://doi.org/10.2174/156802611795429130
60 schema:datePublished 2017-07-17
61 schema:datePublishedReg 2017-07-17
62 schema:description The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have developed a novel method that rapidly screens multiple proteins in parallel using DNA-encoded library technology (ELT). Initial efforts were focused on the efficient discovery of antibacterial leads against 119 targets from Acinetobacter baumannii and Staphylococcus aureus. The success of this effort led to the hypothesis that the relative number of ELT binders alone could be used to assess the ligandability of large sets of proteins. This concept was further explored by screening 42 targets from Mycobacterium tuberculosis. Active chemical series for six targets from our initial effort as well as three chemotypes for DHFR from M. tuberculosis are reported. The findings demonstrate that parallel ELT selections can be used to assess ligandability and highlight opportunities for successful lead and tool discovery.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree true
66 schema:isPartOf N75bf5d9087bc4fa8a94434f0bdabec8d
67 sg:journal.1043282
68 schema:name Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
69 schema:pagination 16081
70 schema:productId N3f81b90ef12b432b8f1360a5646d9e40
71 N9a0a3f1f13c84afa8181787541905605
72 Ncafc21f98e76406993eadc1746d272d8
73 Nd841e1324f964364a3f81bf40489e304
74 Ne41acb1d7f71409c981f5adfc04a8d22
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090738829
76 https://doi.org/10.1038/ncomms16081
77 schema:sdDatePublished 2019-04-10T16:05
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N7dc037e29c6240beb5a1da24bdc9d5fa
80 schema:url https://www.nature.com/articles/ncomms16081
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N07c0462543af4e45866e726db45d8a64 rdf:first sg:person.01271252451.20
85 rdf:rest N1c2419ac1bc34343858e70559bed448c
86 N10c90414862d4c5d9681158813117b85 rdf:first sg:person.0761312310.77
87 rdf:rest N7d5b699cd652476eb458dfd38bda6476
88 N119d9da8123a4e5e86883219b094f32d schema:affiliation https://www.grid.ac/institutes/grid.418019.5
89 schema:familyName Chai
90 schema:givenName Jing
91 rdf:type schema:Person
92 N1213157838f6407aaf0e49df7137bce7 rdf:first Nfdc59d41416c4c27827958fa2361ffec
93 rdf:rest N155baef038ff4dbfb3b8d034abc9cc26
94 N12e6c29460964d10b6bdae814b368c4f rdf:first sg:person.01330713325.10
95 rdf:rest N4fe502ede9194f3991b1f946bd563c2d
96 N151d4f0c0b8e4e5ca2b6d950ac05c4d2 rdf:first sg:person.0703716354.28
97 rdf:rest Ne2400755e85d4f4eac77977be41953a7
98 N155baef038ff4dbfb3b8d034abc9cc26 rdf:first sg:person.012067157062.67
99 rdf:rest N9eef90fd6f224ead8b0ee8c195951a82
100 N191073d4271f45fb8044e81e02c1315e rdf:first Nfaaa5bd712914fe8ab6eec71afd7c6de
101 rdf:rest N73c0ab105f2e4e838caa69a4daec13c7
102 N1a62eefd67794c17a211e961aecfa825 rdf:first N3a9a5190492449d6b5078f3f5bcdccc0
103 rdf:rest N27b3dec211e4443783a8049c3022c438
104 N1c2419ac1bc34343858e70559bed448c rdf:first Nf987bfc372de4638aec6541f12542d56
105 rdf:rest N7070d4ae519e43439dab871e42d1c596
106 N201d524509584253a69ef255791645ee schema:affiliation https://www.grid.ac/institutes/grid.418019.5
107 schema:familyName Chang
108 schema:givenName Sandy S.
109 rdf:type schema:Person
110 N228103ff1b6447178855f85e3f04c8d9 rdf:first N7b4a48cfa3c5498885ac2169338ce738
111 rdf:rest N416af2a88856427f9c90cebb659c1d77
112 N27b3dec211e4443783a8049c3022c438 rdf:first sg:person.01214022621.34
113 rdf:rest N228103ff1b6447178855f85e3f04c8d9
114 N2ad1b24ca92643ff9944bafe022103ed schema:affiliation https://www.grid.ac/institutes/grid.418019.5
115 schema:familyName Li
116 schema:givenName Yue
117 rdf:type schema:Person
118 N2b83a28d33ea4b12a43f5fe52a746ce0 rdf:first sg:person.01312001745.40
119 rdf:rest rdf:nil
120 N39ed98f524f845dd9fdeff67bcdda720 rdf:first sg:person.01023777603.21
121 rdf:rest N49ef1258439142739e70a0bfcdb20d0a
122 N3a9a5190492449d6b5078f3f5bcdccc0 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
123 schema:familyName Martin
124 schema:givenName John
125 rdf:type schema:Person
126 N3f81b90ef12b432b8f1360a5646d9e40 schema:name readcube_id
127 schema:value 4274490798b830df6162f948f30ba72901b794ef0d72f6627a0392d24e0a2e5d
128 rdf:type schema:PropertyValue
129 N416af2a88856427f9c90cebb659c1d77 rdf:first sg:person.0707551203.63
130 rdf:rest N7203d70c8d1d4f67a4b497f3e59c0687
131 N42c7ba31cab4447981236b9c990b34ec rdf:first N2ad1b24ca92643ff9944bafe022103ed
132 rdf:rest N191073d4271f45fb8044e81e02c1315e
133 N4672c0f0b26e4d57a0cf95fd3a52e15f rdf:first sg:person.01320347222.04
134 rdf:rest Nc44757ff88284d9eb2f97e68428385df
135 N46dd7761c40144c3b8836a495aeca0e0 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
136 schema:familyName Wang
137 schema:givenName Juan
138 rdf:type schema:Person
139 N48a321bd5c6b45968e5919a5abd90020 rdf:first sg:person.01147351106.68
140 rdf:rest N1213157838f6407aaf0e49df7137bce7
141 N49ef1258439142739e70a0bfcdb20d0a rdf:first sg:person.0710455704.08
142 rdf:rest Nd585c86fd69d4740abd1489e668718ad
143 N4d78c1bd4e05431f87b4660d34b9f05f rdf:first sg:person.0703605542.50
144 rdf:rest N912e6ab85588435996ece30c01a7c887
145 N4fe502ede9194f3991b1f946bd563c2d rdf:first N46dd7761c40144c3b8836a495aeca0e0
146 rdf:rest N5f8902c5458a4fbeb5fcf0f7ff920aaf
147 N51f1ca7337274c75a4263d4ce2426d58 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
148 schema:familyName O’Keeffe
149 schema:givenName Thomas
150 rdf:type schema:Person
151 N5bb28ffe0932468083e5b252e713ecef rdf:first sg:person.0765672043.38
152 rdf:rest Na7d3c7e32bd44c6e9837b5ea89223f3a
153 N5cfa97331ddd4fdf9bcd5b172128c3f1 rdf:first sg:person.0755747522.78
154 rdf:rest N74fe845bf6834e9ba859675923d52616
155 N5f8902c5458a4fbeb5fcf0f7ff920aaf rdf:first Na9429b9950ec4376acb67b6b91ac504c
156 rdf:rest Nf26f3cf833fd424096f3f277201ae8f3
157 N646a3521b1dc4ff294e7e69770d27284 rdf:first sg:person.0735405665.15
158 rdf:rest N7467565b98e4439aaf474e73883e2298
159 N64bff62dac7d4ecf889ebe818a95d73e rdf:first sg:person.0602571422.20
160 rdf:rest N1a62eefd67794c17a211e961aecfa825
161 N68d41b258cfa4ebe957cad7825becb55 rdf:first sg:person.01062651353.30
162 rdf:rest N646a3521b1dc4ff294e7e69770d27284
163 N6b83fb211ec04e96859574cb33465359 rdf:first sg:person.0772407262.28
164 rdf:rest N42c7ba31cab4447981236b9c990b34ec
165 N7070d4ae519e43439dab871e42d1c596 rdf:first sg:person.016565045243.05
166 rdf:rest N8b7e7630c41b47c1bba782243e099f9d
167 N7203d70c8d1d4f67a4b497f3e59c0687 rdf:first N51f1ca7337274c75a4263d4ce2426d58
168 rdf:rest N8ca32dc1c9f54e228437be2715a50bc8
169 N73c0ab105f2e4e838caa69a4daec13c7 rdf:first Nbd20e49204a148019c608dc0875c9dba
170 rdf:rest Nc8d401feb5ab4d2f92e576ffe1bc3b77
171 N7467565b98e4439aaf474e73883e2298 rdf:first Ne3794983e99145ac8d71bd12ce176f4a
172 rdf:rest N12e6c29460964d10b6bdae814b368c4f
173 N74fe845bf6834e9ba859675923d52616 rdf:first Nd561422cd5044a2688d4f3551a55f94f
174 rdf:rest Nb6430f05759e4206bccfb6730c85d8be
175 N75bf5d9087bc4fa8a94434f0bdabec8d schema:volumeNumber 8
176 rdf:type schema:PublicationVolume
177 N789f0cde496f42db919e3874bc1ec51c rdf:first sg:person.0633252512.86
178 rdf:rest N4672c0f0b26e4d57a0cf95fd3a52e15f
179 N7b4a48cfa3c5498885ac2169338ce738 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
180 schema:familyName McCormick
181 schema:givenName Patti
182 rdf:type schema:Person
183 N7d083a301faf406288b5e873b5bdf5b3 rdf:first N99daba84d3734fd79c9ffe55ccf7ffbe
184 rdf:rest N151d4f0c0b8e4e5ca2b6d950ac05c4d2
185 N7d5b699cd652476eb458dfd38bda6476 rdf:first sg:person.0745347373.92
186 rdf:rest Nd6a3ac9932b54368a1e02ed2d5724ebb
187 N7dc037e29c6240beb5a1da24bdc9d5fa schema:name Springer Nature - SN SciGraph project
188 rdf:type schema:Organization
189 N80cf848ed79d40ca9b6c71ecebfd0068 rdf:first sg:person.01343134030.55
190 rdf:rest Nc1f71c6ca9664c15a4c0503fd04f6159
191 N80ee4cb488ce4380ac112216da0e013a rdf:first Nff1b42d79d3547c5951a9bf9593ec6b7
192 rdf:rest N4d78c1bd4e05431f87b4660d34b9f05f
193 N814da045c2914a489ec1059b0cc19601 rdf:first sg:person.01215035002.70
194 rdf:rest Nce4ef53dfe314816b9e9a1d5002e61f8
195 N88ca688dfa9b4ba2960a0456a6565a5c rdf:first sg:person.01122622201.07
196 rdf:rest N68d41b258cfa4ebe957cad7825becb55
197 N8b7e7630c41b47c1bba782243e099f9d rdf:first sg:person.0762114156.99
198 rdf:rest N5cfa97331ddd4fdf9bcd5b172128c3f1
199 N8ca304f7d1a045afb98091a71c06b280 rdf:first N201d524509584253a69ef255791645ee
200 rdf:rest N9c0e433ef7c940f0af038b19b8ea5f59
201 N8ca32dc1c9f54e228437be2715a50bc8 rdf:first Ne1be1015fb1a455ab0863c6c9983eff5
202 rdf:rest Nfd594b2498b24e39b0116577dcfa2033
203 N8cd7897e15e64519912ba118fd631cf1 rdf:first Nfb79a6d938544ed4bb63a6a3b3e66a8a
204 rdf:rest N2b83a28d33ea4b12a43f5fe52a746ce0
205 N912e6ab85588435996ece30c01a7c887 rdf:first sg:person.014405760213.48
206 rdf:rest N88ca688dfa9b4ba2960a0456a6565a5c
207 N9316e7371a7a41cc8ec8dd575640d077 rdf:first sg:person.012366545337.89
208 rdf:rest Nd27ec9b945a648e69576aeb8165d6c6e
209 N99daba84d3734fd79c9ffe55ccf7ffbe schema:affiliation https://www.grid.ac/institutes/grid.418019.5
210 schema:familyName Huang
211 schema:givenName Jianzhong
212 rdf:type schema:Person
213 N9a0a3f1f13c84afa8181787541905605 schema:name dimensions_id
214 schema:value pub.1090738829
215 rdf:type schema:PropertyValue
216 N9c0e433ef7c940f0af038b19b8ea5f59 rdf:first N119d9da8123a4e5e86883219b094f32d
217 rdf:rest N07c0462543af4e45866e726db45d8a64
218 N9eef90fd6f224ead8b0ee8c195951a82 rdf:first sg:person.016462053213.44
219 rdf:rest N6b83fb211ec04e96859574cb33465359
220 Na2ae1ef6c1b64a3a9cba7afa358ff58c rdf:first sg:person.01253630520.39
221 rdf:rest N80ee4cb488ce4380ac112216da0e013a
222 Na7d3c7e32bd44c6e9837b5ea89223f3a rdf:first Nad894d10cdff414d91cc6ff30f7b935d
223 rdf:rest N8cd7897e15e64519912ba118fd631cf1
224 Na9429b9950ec4376acb67b6b91ac504c schema:affiliation https://www.grid.ac/institutes/grid.418019.5
225 schema:familyName Wang
226 schema:givenName Minghui
227 rdf:type schema:Person
228 Nad894d10cdff414d91cc6ff30f7b935d schema:affiliation https://www.grid.ac/institutes/grid.418019.5
229 schema:familyName Pope
230 schema:givenName Andrew J.
231 rdf:type schema:Person
232 Nb6430f05759e4206bccfb6730c85d8be rdf:first sg:person.0666763731.93
233 rdf:rest Nbdffcd6444474510a8cc6f2d46d0f0f3
234 Nbd20e49204a148019c608dc0875c9dba schema:affiliation https://www.grid.ac/institutes/grid.418019.5
235 schema:familyName Lu
236 schema:givenName Quinn
237 rdf:type schema:Person
238 Nbd4c55397f434441baa6bc2c54296f66 rdf:first Nd2350b9e971343ef9c2a950051d4c0d7
239 rdf:rest N5bb28ffe0932468083e5b252e713ecef
240 Nbdffcd6444474510a8cc6f2d46d0f0f3 rdf:first sg:person.011303627613.65
241 rdf:rest N10c90414862d4c5d9681158813117b85
242 Nbe0ba24a417f4927a50cc5b08ca10227 rdf:first sg:person.01073063147.12
243 rdf:rest Nbd4c55397f434441baa6bc2c54296f66
244 Nc0a18d4f2b914056a95b156e5d0ad26b rdf:first sg:person.01052545614.54
245 rdf:rest Nbe0ba24a417f4927a50cc5b08ca10227
246 Nc1f71c6ca9664c15a4c0503fd04f6159 rdf:first sg:person.0713715543.20
247 rdf:rest N8ca304f7d1a045afb98091a71c06b280
248 Nc44757ff88284d9eb2f97e68428385df rdf:first Ndc325448540547a7a3b711962f069b7e
249 rdf:rest Nf3a6b13e6599464eaec1db0355fdd2e4
250 Nc8d401feb5ab4d2f92e576ffe1bc3b77 rdf:first sg:person.0723272577.32
251 rdf:rest N64bff62dac7d4ecf889ebe818a95d73e
252 Ncafc21f98e76406993eadc1746d272d8 schema:name doi
253 schema:value 10.1038/ncomms16081
254 rdf:type schema:PropertyValue
255 Nce4ef53dfe314816b9e9a1d5002e61f8 rdf:first sg:person.0642342504.18
256 rdf:rest N39ed98f524f845dd9fdeff67bcdda720
257 Nd2350b9e971343ef9c2a950051d4c0d7 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
258 schema:familyName Holmes
259 schema:givenName David
260 rdf:type schema:Person
261 Nd27ec9b945a648e69576aeb8165d6c6e rdf:first sg:person.01022102260.37
262 rdf:rest N80cf848ed79d40ca9b6c71ecebfd0068
263 Nd561422cd5044a2688d4f3551a55f94f schema:affiliation https://www.grid.ac/institutes/grid.418019.5
264 schema:familyName Ding
265 schema:givenName Yun
266 rdf:type schema:Person
267 Nd585c86fd69d4740abd1489e668718ad rdf:first sg:person.01162123151.51
268 rdf:rest N7d083a301faf406288b5e873b5bdf5b3
269 Nd6a3ac9932b54368a1e02ed2d5724ebb rdf:first sg:person.0577667173.05
270 rdf:rest N48a321bd5c6b45968e5919a5abd90020
271 Nd841e1324f964364a3f81bf40489e304 schema:name pubmed_id
272 schema:value 28714473
273 rdf:type schema:PropertyValue
274 Ndc325448540547a7a3b711962f069b7e schema:affiliation https://www.grid.ac/institutes/grid.418019.5
275 schema:familyName Zhang
276 schema:givenName Jean
277 rdf:type schema:Person
278 Ne1be1015fb1a455ab0863c6c9983eff5 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
279 schema:familyName Pao
280 schema:givenName Christina
281 rdf:type schema:Person
282 Ne2400755e85d4f4eac77977be41953a7 rdf:first sg:person.01260621143.89
283 rdf:rest N9316e7371a7a41cc8ec8dd575640d077
284 Ne3794983e99145ac8d71bd12ce176f4a schema:affiliation https://www.grid.ac/institutes/grid.418019.5
285 schema:familyName Taylor
286 schema:givenName Amy
287 rdf:type schema:Person
288 Ne41acb1d7f71409c981f5adfc04a8d22 schema:name nlm_unique_id
289 schema:value 101528555
290 rdf:type schema:PropertyValue
291 Nf26f3cf833fd424096f3f277201ae8f3 rdf:first sg:person.013061132413.01
292 rdf:rest N789f0cde496f42db919e3874bc1ec51c
293 Nf36862e8f8314094b7e50049901097b3 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
294 schema:familyName Zhou
295 schema:givenName Jingye
296 rdf:type schema:Person
297 Nf3a6b13e6599464eaec1db0355fdd2e4 rdf:first Nf36862e8f8314094b7e50049901097b3
298 rdf:rest Nc0a18d4f2b914056a95b156e5d0ad26b
299 Nf987bfc372de4638aec6541f12542d56 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
300 schema:familyName Coffin
301 schema:givenName Aaron
302 rdf:type schema:Person
303 Nfaaa5bd712914fe8ab6eec71afd7c6de schema:affiliation https://www.grid.ac/institutes/grid.418019.5
304 schema:familyName Liu
305 schema:givenName Xiaorong
306 rdf:type schema:Person
307 Nfb79a6d938544ed4bb63a6a3b3e66a8a schema:affiliation https://www.grid.ac/institutes/grid.418019.5
308 schema:familyName Gross
309 schema:givenName Jeffrey W.
310 rdf:type schema:Person
311 Nfd594b2498b24e39b0116577dcfa2033 rdf:first sg:person.012771744767.78
312 rdf:rest Na2ae1ef6c1b64a3a9cba7afa358ff58c
313 Nfdc59d41416c4c27827958fa2361ffec schema:affiliation https://www.grid.ac/institutes/grid.418019.5
314 schema:familyName Johnson
315 schema:givenName Walter P.
316 rdf:type schema:Person
317 Nff1b42d79d3547c5951a9bf9593ec6b7 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
318 schema:familyName Rafferty
319 schema:givenName Keith
320 rdf:type schema:Person
321 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
322 schema:name Medical and Health Sciences
323 rdf:type schema:DefinedTerm
324 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
325 schema:name Medical Microbiology
326 rdf:type schema:DefinedTerm
327 sg:journal.1043282 schema:issn 2041-1723
328 schema:name Nature Communications
329 rdf:type schema:Periodical
330 sg:person.01022102260.37 schema:affiliation https://www.grid.ac/institutes/grid.419327.a
331 schema:familyName Barros-Aguirre
332 schema:givenName David
333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022102260.37
334 rdf:type schema:Person
335 sg:person.01023777603.21 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
336 schema:familyName Lind
337 schema:givenName Kenneth E.
338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023777603.21
339 rdf:type schema:Person
340 sg:person.01052545614.54 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
341 schema:familyName Donahue
342 schema:givenName Christine P.
343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052545614.54
344 rdf:type schema:Person
345 sg:person.01062651353.30 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
346 schema:familyName Sweitzer
347 schema:givenName Sharon M.
348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062651353.30
349 rdf:type schema:Person
350 sg:person.01073063147.12 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
351 schema:familyName Messer
352 schema:givenName Jeffrey A.
353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073063147.12
354 rdf:type schema:Person
355 sg:person.01122622201.07 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
356 schema:familyName Sundersingh
357 schema:givenName Flora S.
358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122622201.07
359 rdf:type schema:Person
360 sg:person.011303627613.65 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
361 schema:familyName Fosbenner
362 schema:givenName David T.
363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011303627613.65
364 rdf:type schema:Person
365 sg:person.01147351106.68 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
366 schema:familyName Ingraham
367 schema:givenName Karen
368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147351106.68
369 rdf:type schema:Person
370 sg:person.01162123151.51 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
371 schema:familyName Chan
372 schema:givenName Pan F.
373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162123151.51
374 rdf:type schema:Person
375 sg:person.012067157062.67 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
376 schema:familyName King
377 schema:givenName Bryan W.
378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012067157062.67
379 rdf:type schema:Person
380 sg:person.01214022621.34 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
381 schema:familyName McCloskey
382 schema:givenName Lynn
383 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214022621.34
384 rdf:type schema:Person
385 sg:person.01215035002.70 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
386 schema:familyName Machutta
387 schema:givenName Carl A.
388 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215035002.70
389 rdf:type schema:Person
390 sg:person.012366545337.89 schema:affiliation https://www.grid.ac/institutes/grid.6572.6
391 schema:familyName Besra
392 schema:givenName Gurdyal S.
393 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012366545337.89
394 rdf:type schema:Person
395 sg:person.01253630520.39 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
396 schema:familyName Qi
397 schema:givenName Hongwei
398 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253630520.39
399 rdf:type schema:Person
400 sg:person.01260621143.89 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
401 schema:familyName Belyanskaya
402 schema:givenName Svetlana
403 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260621143.89
404 rdf:type schema:Person
405 sg:person.01271252451.20 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
406 schema:familyName Choudhry
407 schema:givenName Anthony E.
408 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271252451.20
409 rdf:type schema:Person
410 sg:person.012771744767.78 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
411 schema:familyName Phelps
412 schema:givenName Christopher B.
413 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012771744767.78
414 rdf:type schema:Person
415 sg:person.013061132413.01 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
416 schema:familyName Wilkins
417 schema:givenName Devan J.
418 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013061132413.01
419 rdf:type schema:Person
420 sg:person.01312001745.40 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
421 schema:familyName Evindar
422 schema:givenName Ghotas
423 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312001745.40
424 rdf:type schema:Person
425 sg:person.01320347222.04 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
426 schema:familyName Yao
427 schema:givenName Gang
428 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320347222.04
429 rdf:type schema:Person
430 sg:person.01330713325.10 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
431 schema:familyName Toh
432 schema:givenName May Fern
433 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330713325.10
434 rdf:type schema:Person
435 sg:person.01343134030.55 schema:affiliation https://www.grid.ac/institutes/grid.419327.a
436 schema:familyName Bates
437 schema:givenName Robert H.
438 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343134030.55
439 rdf:type schema:Person
440 sg:person.014405760213.48 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
441 schema:familyName Steiginga
442 schema:givenName Matt S.
443 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014405760213.48
444 rdf:type schema:Person
445 sg:person.016462053213.44 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
446 schema:familyName Kwiatkowski
447 schema:givenName Christopher R.
448 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016462053213.44
449 rdf:type schema:Person
450 sg:person.016565045243.05 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
451 schema:familyName Davie
452 schema:givenName Christopher P.
453 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016565045243.05
454 rdf:type schema:Person
455 sg:person.0577667173.05 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
456 schema:familyName Graybill
457 schema:givenName Todd L.
458 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577667173.05
459 rdf:type schema:Person
460 sg:person.0602571422.20 schema:affiliation https://www.grid.ac/institutes/grid.419327.a
461 schema:familyName Mendoza-Losana
462 schema:givenName Alfonso
463 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602571422.20
464 rdf:type schema:Person
465 sg:person.0633252512.86 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
466 schema:familyName Xia
467 schema:givenName Bing
468 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633252512.86
469 rdf:type schema:Person
470 sg:person.0642342504.18 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
471 schema:familyName Kollmann
472 schema:givenName Christopher S.
473 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642342504.18
474 rdf:type schema:Person
475 sg:person.0666763731.93 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
476 schema:familyName Dodson
477 schema:givenName Jason W.
478 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666763731.93
479 rdf:type schema:Person
480 sg:person.0703605542.50 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
481 schema:familyName Scavello
482 schema:givenName Genaro S.
483 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703605542.50
484 rdf:type schema:Person
485 sg:person.0703716354.28 schema:affiliation https://www.grid.ac/institutes/grid.419327.a
486 schema:familyName Ballell
487 schema:givenName Lluis
488 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703716354.28
489 rdf:type schema:Person
490 sg:person.0707551203.63 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
491 schema:familyName O’Keefe
492 schema:givenName Heather P.
493 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707551203.63
494 rdf:type schema:Person
495 sg:person.0710455704.08 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
496 schema:familyName Bai
497 schema:givenName Xiaopeng
498 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710455704.08
499 rdf:type schema:Person
500 sg:person.0713715543.20 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
501 schema:familyName Centrella
502 schema:givenName Paolo A.
503 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713715543.20
504 rdf:type schema:Person
505 sg:person.0723272577.32 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
506 schema:familyName Lehr
507 schema:givenName Ruth
508 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723272577.32
509 rdf:type schema:Person
510 sg:person.0735405665.15 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
511 schema:familyName Szewczuk
512 schema:givenName Lawrence M.
513 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735405665.15
514 rdf:type schema:Person
515 sg:person.0745347373.92 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
516 schema:familyName Graham
517 schema:givenName Taylor L.
518 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745347373.92
519 rdf:type schema:Person
520 sg:person.0755747522.78 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
521 schema:familyName Deng
522 schema:givenName Jianghe
523 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755747522.78
524 rdf:type schema:Person
525 sg:person.0761312310.77 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
526 schema:familyName Gao
527 schema:givenName Enoch N.
528 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761312310.77
529 rdf:type schema:Person
530 sg:person.0762114156.99 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
531 schema:familyName Deng
532 schema:givenName Hongfeng
533 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762114156.99
534 rdf:type schema:Person
535 sg:person.0765672043.38 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
536 schema:familyName Arico-Muendel
537 schema:givenName Christopher C.
538 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765672043.38
539 rdf:type schema:Person
540 sg:person.0772407262.28 schema:affiliation https://www.grid.ac/institutes/grid.419327.a
541 schema:familyName Lelièvre
542 schema:givenName Joël
543 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772407262.28
544 rdf:type schema:Person
545 sg:pub.10.1007/s00894-010-0683-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1035307573
546 https://doi.org/10.1007/s00894-010-0683-y
547 rdf:type schema:CreativeWork
548 sg:pub.10.1038/470163a schema:sameAs https://app.dimensions.ai/details/publication/pub.1045497536
549 https://doi.org/10.1038/470163a
550 rdf:type schema:CreativeWork
551 sg:pub.10.1038/530367a schema:sameAs https://app.dimensions.ai/details/publication/pub.1035213550
552 https://doi.org/10.1038/530367a
553 rdf:type schema:CreativeWork
554 sg:pub.10.1038/nature17042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038585164
555 https://doi.org/10.1038/nature17042
556 rdf:type schema:CreativeWork
557 sg:pub.10.1038/nbt961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035924874
558 https://doi.org/10.1038/nbt961
559 rdf:type schema:CreativeWork
560 sg:pub.10.1038/nchembio.1427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006324154
561 https://doi.org/10.1038/nchembio.1427
562 rdf:type schema:CreativeWork
563 sg:pub.10.1038/nchembio.1429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012221959
564 https://doi.org/10.1038/nchembio.1429
565 rdf:type schema:CreativeWork
566 sg:pub.10.1038/nchembio.1867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046035901
567 https://doi.org/10.1038/nchembio.1867
568 rdf:type schema:CreativeWork
569 sg:pub.10.1038/nchembio.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022121817
570 https://doi.org/10.1038/nchembio.211
571 rdf:type schema:CreativeWork
572 sg:pub.10.1038/nchembio0708-382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048495800
573 https://doi.org/10.1038/nchembio0708-382
574 rdf:type schema:CreativeWork
575 sg:pub.10.1038/nprot.2016.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019024909
576 https://doi.org/10.1038/nprot.2016.039
577 rdf:type schema:CreativeWork
578 sg:pub.10.1038/nrd.2016.213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005381791
579 https://doi.org/10.1038/nrd.2016.213
580 rdf:type schema:CreativeWork
581 sg:pub.10.1038/nrd2201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005793977
582 https://doi.org/10.1038/nrd2201
583 rdf:type schema:CreativeWork
584 sg:pub.10.1038/nrd3681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035163834
585 https://doi.org/10.1038/nrd3681
586 rdf:type schema:CreativeWork
587 sg:pub.10.1038/nrd3701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005505350
588 https://doi.org/10.1038/nrd3701
589 rdf:type schema:CreativeWork
590 sg:pub.10.1038/nrd4650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034610869
591 https://doi.org/10.1038/nrd4650
592 rdf:type schema:CreativeWork
593 sg:pub.10.1038/nrd4783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002982107
594 https://doi.org/10.1038/nrd4783
595 rdf:type schema:CreativeWork
596 https://doi.org/10.1002/anie.201410736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000671106
597 rdf:type schema:CreativeWork
598 https://doi.org/10.1002/anie.201612143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026368502
599 rdf:type schema:CreativeWork
600 https://doi.org/10.1002/cbic.201600567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016377022
601 rdf:type schema:CreativeWork
602 https://doi.org/10.1002/cbic.201600573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035348169
603 rdf:type schema:CreativeWork
604 https://doi.org/10.1002/cbic.201600660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018754194
605 rdf:type schema:CreativeWork
606 https://doi.org/10.1002/cmdc.201300429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021942218
607 rdf:type schema:CreativeWork
608 https://doi.org/10.1016/j.bmc.2014.01.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009934162
609 rdf:type schema:CreativeWork
610 https://doi.org/10.1016/j.bmcl.2012.01.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048912243
611 rdf:type schema:CreativeWork
612 https://doi.org/10.1016/j.bmcl.2013.04.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028752832
613 rdf:type schema:CreativeWork
614 https://doi.org/10.1016/j.drudis.2011.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002389259
615 rdf:type schema:CreativeWork
616 https://doi.org/10.1016/j.drudis.2016.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004553457
617 rdf:type schema:CreativeWork
618 https://doi.org/10.1016/s1359-6446(05)03624-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008182859
619 rdf:type schema:CreativeWork
620 https://doi.org/10.1016/s1359-6446(05)03666-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021100332
621 rdf:type schema:CreativeWork
622 https://doi.org/10.1021/acs.bioconjchem.5b00239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055081985
623 rdf:type schema:CreativeWork
624 https://doi.org/10.1021/acs.jmedchem.6b00746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055100231
625 rdf:type schema:CreativeWork
626 https://doi.org/10.1021/acschembio.5b00981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016737567
627 rdf:type schema:CreativeWork
628 https://doi.org/10.1021/acsmedchemlett.5b00025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031954610
629 rdf:type schema:CreativeWork
630 https://doi.org/10.1021/acsmedchemlett.5b00179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000098905
631 rdf:type schema:CreativeWork
632 https://doi.org/10.1021/cb400896g schema:sameAs https://app.dimensions.ai/details/publication/pub.1015816593
633 rdf:type schema:CreativeWork
634 https://doi.org/10.1021/ci200613b schema:sameAs https://app.dimensions.ai/details/publication/pub.1055402859
635 rdf:type schema:CreativeWork
636 https://doi.org/10.1021/co5001037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006767278
637 rdf:type schema:CreativeWork
638 https://doi.org/10.1021/ja015873n schema:sameAs https://app.dimensions.ai/details/publication/pub.1039619647
639 rdf:type schema:CreativeWork
640 https://doi.org/10.1021/ja808558a schema:sameAs https://app.dimensions.ai/details/publication/pub.1009313128
641 rdf:type schema:CreativeWork
642 https://doi.org/10.1021/jm049131r schema:sameAs https://app.dimensions.ai/details/publication/pub.1055948902
643 rdf:type schema:CreativeWork
644 https://doi.org/10.1021/jm300449x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005047465
645 rdf:type schema:CreativeWork
646 https://doi.org/10.1021/jm400204k schema:sameAs https://app.dimensions.ai/details/publication/pub.1024940714
647 rdf:type schema:CreativeWork
648 https://doi.org/10.1021/jm401326j schema:sameAs https://app.dimensions.ai/details/publication/pub.1044824154
649 rdf:type schema:CreativeWork
650 https://doi.org/10.1039/c1cs15076f schema:sameAs https://app.dimensions.ai/details/publication/pub.1006980820
651 rdf:type schema:CreativeWork
652 https://doi.org/10.1039/c5cc01230a schema:sameAs https://app.dimensions.ai/details/publication/pub.1039619879
653 rdf:type schema:CreativeWork
654 https://doi.org/10.1046/j.1365-2958.2002.02832.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025056780
655 rdf:type schema:CreativeWork
656 https://doi.org/10.1073/pnas.1610978113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011079427
657 rdf:type schema:CreativeWork
658 https://doi.org/10.1073/pnas.89.12.5381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041627906
659 rdf:type schema:CreativeWork
660 https://doi.org/10.1098/rstb.2014.0086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034345147
661 rdf:type schema:CreativeWork
662 https://doi.org/10.1128/aac.00834-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042206726
663 rdf:type schema:CreativeWork
664 https://doi.org/10.1177/1087057116637353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046325437
665 rdf:type schema:CreativeWork
666 https://doi.org/10.1371/journal.pone.0077142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012425551
667 rdf:type schema:CreativeWork
668 https://doi.org/10.1517/17460441.3.4.391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010675663
669 rdf:type schema:CreativeWork
670 https://doi.org/10.2174/156802607780059781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069193470
671 rdf:type schema:CreativeWork
672 https://doi.org/10.2174/156802611795429130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026287292
673 rdf:type schema:CreativeWork
674 https://www.grid.ac/institutes/grid.418019.5 schema:alternateName GlaxoSmithKline (United States)
675 schema:name GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA
676 GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA
677 rdf:type schema:Organization
678 https://www.grid.ac/institutes/grid.419327.a schema:alternateName GlaxoSmithKline (Spain)
679 schema:name GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain
680 rdf:type schema:Organization
681 https://www.grid.ac/institutes/grid.6572.6 schema:alternateName University of Birmingham
682 schema:name University of Birmingham, School of Biosciences, Edgbaston, Birmingham B15 2TT, UK
683 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...