Coordinated force generation of skeletal myosins in myofilaments through motor coupling View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07-06

AUTHORS

Motoshi Kaya, Yoshiaki Tani, Takumi Washio, Toshiaki Hisada, Hideo Higuchi

ABSTRACT

In contrast to processive molecular motors, skeletal myosins form a large motor ensemble for contraction of muscles against high loads. Despite numerous information on the molecular properties of skeletal myosin, its ensemble effects on collective force generation have not been rigorously clarified. Here we show 4 nm stepwise actin displacements generated by synthetic myofilaments beyond a load of 30 pN, implying that steps cannot be driven exclusively by single myosins, but potentially by coordinated force generations among multiple myosins. The simulation model shows that stepwise actin displacements are primarily caused by coordinated force generation among myosin molecules. Moreover, the probability of coordinated force generation can be enhanced against high loads by utilizing three factors: strain-dependent kinetics between force-generating states; multiple power stroke steps; and high ATP concentrations. Compared with other molecular motors, our findings reveal how the properties of skeletal myosin are tuned to perform cooperative force generation for efficient muscle contraction. More... »

PAGES

16036

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms16036

DOI

http://dx.doi.org/10.1038/ncomms16036

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090358608

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28681850


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