The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06-12

AUTHORS

Kyungsoo Ha, Chengxian Ma, Han Lin, Lichun Tang, Zhusheng Lian, Fang Zhao, Ju-Mei Li, Bei Zhen, Huadong Pei, Suxia Han, Marcos Malumbres, Jianping Jin, Huan Chen, Yongxiang Zhao, Qing Zhu, Pumin Zhang

ABSTRACT

Double-strand breaks (DSBs) are repaired through two major pathways, homology-directed recombination (HDR) and non-homologous end joining (NHEJ). While HDR can only occur in S/G2, NHEJ can happen in all cell cycle phases (except mitosis). How then is the repair choice made in S/G2 cells? Here we provide evidence demonstrating that APCCdh1 plays a critical role in choosing the repair pathways in S/G2 cells. Our results suggest that the default for all DSBs is to recruit 53BP1 and RIF1. BRCA1 is blocked from being recruited to broken ends because its recruitment signal, K63-linked poly-ubiquitin chains on histones, is actively destroyed by the deubiquitinating enzyme USP1. We show that the removal of USP1 depends on APCCdh1 and requires Chk1 activation known to be catalysed by ssDNA-RPA-ATR signalling at the ends designated for HDR, linking the status of end processing to RIF1 or BRCA1 recruitment. More... »

PAGES

15751

References to SciGraph publications

  • 2009-01-19. The function of APC/CCdh1 in cell cycle and beyond in CELL DIVISION
  • 2003-08-28. Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation in ONCOGENE
  • 2009-12. Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks in NATURE
  • 2010-08-15. Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells in NATURE CELL BIOLOGY
  • 2010-04-12. p53- and p21-dependent premature APC/C–Cdh1 activation in G2 is part of the long-term response to genotoxic stress in ONCOGENE
  • 2010-08. Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1 in NATURE
  • 2009-11-24. Lentivirus Vectors for Stably Introducing Genes into Mammary Epithelial Cells in Vivo in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 2011-11-27. The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2013-06-12. 53BP1 is a reader of the DNA damage-induced H2A Lys15 ubiquitin mark in NATURE
  • 2002-03-18. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation in NATURE CELL BIOLOGY
  • 2015-04-24. Replication stress and cancer in NATURE REVIEWS CANCER
  • 2016-01-05. A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice in NATURE COMMUNICATIONS
  • 2015-10-21. Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage in NATURE
  • 2009-10. The DNA-damage response in human biology and disease in NATURE
  • 2015-08-17. Recruitment and activation of the ATM kinase in the absence of DNA damage sensors in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-06-15. Genomic stability and tumour suppression by the APC/C cofactor Cdh1 in NATURE CELL BIOLOGY
  • 2008-02-20. Regulation of DNA repair throughout the cell cycle in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2005-01-23. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms15751

    DOI

    http://dx.doi.org/10.1038/ncomms15751

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085985067

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28604711


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anaphase-Promoting Complex-Cyclosome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Breaks, Double-Stranded", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Damage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Repair", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genomic Instability", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HEK293 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HeLa Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ubiquitin", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "National Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China", 
                "State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China", 
                "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ha", 
            "givenName": "Kyungsoo", 
            "id": "sg:person.015065125137.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015065125137.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710004, China", 
              "id": "http://www.grid.ac/institutes/grid.452672.0", 
              "name": [
                "Department of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710004, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ma", 
            "givenName": "Chengxian", 
            "id": "sg:person.011352415517.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011352415517.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lin", 
            "givenName": "Han", 
            "id": "sg:person.01007252565.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007252565.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "National Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China", 
                "State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tang", 
            "givenName": "Lichun", 
            "id": "sg:person.01136627202.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136627202.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710061, China", 
              "id": "http://www.grid.ac/institutes/grid.452438.c", 
              "name": [
                "Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710061, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lian", 
            "givenName": "Zhusheng", 
            "id": "sg:person.012070570543.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012070570543.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for International Research of Biological Targeting Diagnosis and Therapy, and Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Guangxi 530021, China", 
              "id": "http://www.grid.ac/institutes/grid.256607.0", 
              "name": [
                "National Center for International Research of Biological Targeting Diagnosis and Therapy, and Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Guangxi 530021, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Fang", 
            "id": "sg:person.011234703267.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011234703267.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biochemistry and Molecular Biology, University of Texas Health Sciences Center, Houston, Texas 77030, USA", 
              "id": "http://www.grid.ac/institutes/grid.267308.8", 
              "name": [
                "Department of Biochemistry and Molecular Biology, University of Texas Health Sciences Center, Houston, Texas 77030, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Ju-Mei", 
            "id": "sg:person.01066044464.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066044464.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "National Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China", 
                "State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhen", 
            "givenName": "Bei", 
            "id": "sg:person.0653471144.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653471144.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "National Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China", 
                "State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pei", 
            "givenName": "Huadong", 
            "id": "sg:person.01245660406.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245660406.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710061, China", 
              "id": "http://www.grid.ac/institutes/grid.452438.c", 
              "name": [
                "Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710061, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Han", 
            "givenName": "Suxia", 
            "id": "sg:person.016416255555.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016416255555.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Spanish National Cancer Research Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Malumbres", 
            "givenName": "Marcos", 
            "id": "sg:person.0716321250.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716321250.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biochemistry and Molecular Biology, University of Texas Health Sciences Center, Houston, Texas 77030, USA", 
              "id": "http://www.grid.ac/institutes/grid.267308.8", 
              "name": [
                "Department of Biochemistry and Molecular Biology, University of Texas Health Sciences Center, Houston, Texas 77030, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jin", 
            "givenName": "Jianping", 
            "id": "sg:person.013264415067.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013264415067.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "National Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China", 
                "State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Huan", 
            "id": "sg:person.0670442647.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670442647.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for International Research of Biological Targeting Diagnosis and Therapy, and Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Guangxi 530021, China", 
              "id": "http://www.grid.ac/institutes/grid.256607.0", 
              "name": [
                "National Center for International Research of Biological Targeting Diagnosis and Therapy, and Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Guangxi 530021, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Yongxiang", 
            "id": "sg:person.01334165400.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334165400.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710004, China", 
              "id": "http://www.grid.ac/institutes/grid.452672.0", 
              "name": [
                "Department of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710004, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhu", 
            "givenName": "Qing", 
            "id": "sg:person.01066070236.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066070236.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "National Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China", 
                "State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China", 
                "Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Pumin", 
            "id": "sg:person.0655537451.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655537451.33"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature09297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000399358", 
              "https://doi.org/10.1038/nature09297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046919299", 
              "https://doi.org/10.1038/nature08657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms10201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025922958", 
              "https://doi.org/10.1038/ncomms10201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1747-1028-4-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025501915", 
              "https://doi.org/10.1186/1747-1028-4-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052177787", 
              "https://doi.org/10.1038/nature15401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026442022", 
              "https://doi.org/10.1038/sj.onc.1206678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052581766", 
              "https://doi.org/10.1038/nature08467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024640130", 
              "https://doi.org/10.1038/ncb2092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10911-009-9154-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013912681", 
              "https://doi.org/10.1007/s10911-009-9154-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000270527", 
              "https://doi.org/10.1038/nature12318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048455891", 
              "https://doi.org/10.1038/nrm2351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036286393", 
              "https://doi.org/10.1038/onc.2010.99"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1742", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006184899", 
              "https://doi.org/10.1038/ncb1742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.3072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035141119", 
              "https://doi.org/10.1038/nsmb.3072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004022288", 
              "https://doi.org/10.1038/nrc3916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043148411", 
              "https://doi.org/10.1038/nsmb.2188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012198218", 
              "https://doi.org/10.1038/ncb1212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000490799", 
              "https://doi.org/10.1038/ncb777"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-06-12", 
        "datePublishedReg": "2017-06-12", 
        "description": "Double-strand breaks (DSBs) are repaired through two major pathways, homology-directed recombination (HDR) and non-homologous end joining (NHEJ). While HDR can only occur in S/G2, NHEJ can happen in all cell cycle phases (except mitosis). How then is the repair choice made in S/G2 cells? Here we provide evidence demonstrating that APCCdh1 plays a critical role in choosing the repair pathways in S/G2 cells. Our results suggest that the default for all DSBs is to recruit 53BP1 and RIF1. BRCA1 is blocked from being recruited to broken ends because its recruitment signal, K63-linked poly-ubiquitin chains on histones, is actively destroyed by the deubiquitinating enzyme USP1. We show that the removal of USP1 depends on APCCdh1 and requires Chk1 activation known to be catalysed by ssDNA-RPA-ATR signalling at the ends designated for HDR, linking the status of end processing to RIF1 or BRCA1 recruitment.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/ncomms15751", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2439020", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2684382", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2521795", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438877", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8339064", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2674650", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2478296", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2699254", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438696", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6978258", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2478904", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7203581", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8342756", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2439241", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2383896", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "keywords": [
          "homology-directed recombination", 
          "double-strand breaks", 
          "deubiquitinating enzyme USP1", 
          "DNA damage sites", 
          "poly-ubiquitin chains", 
          "repair choice", 
          "non-homologous end", 
          "cell cycle phases", 
          "G2 cells", 
          "Chk1 activation", 
          "BRCA1 recruitment", 
          "repair pathways", 
          "end processing", 
          "recruitment signals", 
          "damage sites", 
          "broken ends", 
          "Rif1", 
          "USP1", 
          "major pathway", 
          "critical role", 
          "pathway", 
          "cycle phase", 
          "histones", 
          "cells", 
          "NHEJ", 
          "K63", 
          "anaphase", 
          "ubiquitin", 
          "APC", 
          "sup", 
          "recombination", 
          "BRCA1", 
          "recruitment", 
          "activation", 
          "sites", 
          "breaks", 
          "role", 
          "G2", 
          "chain", 
          "signals", 
          "end", 
          "evidence", 
          "removal", 
          "status", 
          "results", 
          "processing", 
          "phase", 
          "choice", 
          "default", 
          "enzyme USP1", 
          "removal of USP1", 
          "RPA-ATR", 
          "complex impacts repair choice", 
          "impacts repair choice"
        ], 
        "name": "The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites", 
        "pagination": "15751", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1085985067"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ncomms15751"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28604711"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ncomms15751", 
          "https://app.dimensions.ai/details/publication/pub.1085985067"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_732.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/ncomms15751"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms15751'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms15751'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms15751'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms15751'


     

    This table displays all metadata directly associated to this object as RDF triples.

    399 TRIPLES      22 PREDICATES      112 URIs      86 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ncomms15751 schema:about N170ebca196a84e359efa5da142ffa000
    2 N2172a023535745f0b6d6a43075f85dac
    3 N40a27dbb35fa4d45847b3b57b4faf86e
    4 N51393a97cb81413db938e951a182a2b4
    5 N6e8d0a57c0594e3995d6a58cde8f727d
    6 N8b7e3632119b49feb662807d7f8115ce
    7 N9a817f831b9c4474b764a1e3373a6f00
    8 Na79b17fa4ae7460d96c376059d53cddb
    9 Na972616f959b404e922efd0747b6566a
    10 Nb40e2c7bec3d454d89cdbd08e70982c7
    11 Nc24ee8dc2219482089f7bc8c80369b0a
    12 Nd54bdbeb178143daa95ef63e02c53101
    13 Ne167ae26c7a242ab868a848c3202c7d1
    14 Ne36c562808d5427d9293e1e003d57838
    15 anzsrc-for:06
    16 anzsrc-for:0601
    17 schema:author N1fe68d86aefc4e53b94693acdfd0f3d2
    18 schema:citation sg:pub.10.1007/s10911-009-9154-4
    19 sg:pub.10.1038/nature08467
    20 sg:pub.10.1038/nature08657
    21 sg:pub.10.1038/nature09297
    22 sg:pub.10.1038/nature12318
    23 sg:pub.10.1038/nature15401
    24 sg:pub.10.1038/ncb1212
    25 sg:pub.10.1038/ncb1742
    26 sg:pub.10.1038/ncb2092
    27 sg:pub.10.1038/ncb777
    28 sg:pub.10.1038/ncomms10201
    29 sg:pub.10.1038/nrc3916
    30 sg:pub.10.1038/nrm2351
    31 sg:pub.10.1038/nsmb.2188
    32 sg:pub.10.1038/nsmb.3072
    33 sg:pub.10.1038/onc.2010.99
    34 sg:pub.10.1038/sj.onc.1206678
    35 sg:pub.10.1186/1747-1028-4-2
    36 schema:datePublished 2017-06-12
    37 schema:datePublishedReg 2017-06-12
    38 schema:description Double-strand breaks (DSBs) are repaired through two major pathways, homology-directed recombination (HDR) and non-homologous end joining (NHEJ). While HDR can only occur in S/G2, NHEJ can happen in all cell cycle phases (except mitosis). How then is the repair choice made in S/G2 cells? Here we provide evidence demonstrating that APC<sup>Cdh1</sup> plays a critical role in choosing the repair pathways in S/G2 cells. Our results suggest that the default for all DSBs is to recruit 53BP1 and RIF1. BRCA1 is blocked from being recruited to broken ends because its recruitment signal, K63-linked poly-ubiquitin chains on histones, is actively destroyed by the deubiquitinating enzyme USP1. We show that the removal of USP1 depends on APC<sup>Cdh1</sup> and requires Chk1 activation known to be catalysed by ssDNA-RPA-ATR signalling at the ends designated for HDR, linking the status of end processing to RIF1 or BRCA1 recruitment.
    39 schema:genre article
    40 schema:inLanguage en
    41 schema:isAccessibleForFree true
    42 schema:isPartOf Nafdf6f25f84b4375b21b4677fc6bf0eb
    43 Nfe9d81274ef34f7ea1961ed1cdd2fdc2
    44 sg:journal.1043282
    45 schema:keywords APC
    46 BRCA1
    47 BRCA1 recruitment
    48 Chk1 activation
    49 DNA damage sites
    50 G2
    51 G2 cells
    52 K63
    53 NHEJ
    54 RPA-ATR
    55 Rif1
    56 USP1
    57 activation
    58 anaphase
    59 breaks
    60 broken ends
    61 cell cycle phases
    62 cells
    63 chain
    64 choice
    65 complex impacts repair choice
    66 critical role
    67 cycle phase
    68 damage sites
    69 default
    70 deubiquitinating enzyme USP1
    71 double-strand breaks
    72 end
    73 end processing
    74 enzyme USP1
    75 evidence
    76 histones
    77 homology-directed recombination
    78 impacts repair choice
    79 major pathway
    80 non-homologous end
    81 pathway
    82 phase
    83 poly-ubiquitin chains
    84 processing
    85 recombination
    86 recruitment
    87 recruitment signals
    88 removal
    89 removal of USP1
    90 repair choice
    91 repair pathways
    92 results
    93 role
    94 signals
    95 sites
    96 status
    97 sup
    98 ubiquitin
    99 schema:name The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
    100 schema:pagination 15751
    101 schema:productId N446a3eb897f04d298d653b8b71b84ee9
    102 N55954e18c21346c9bccb3273966cec59
    103 Nff244bd05f5d4b13baa0513981001464
    104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085985067
    105 https://doi.org/10.1038/ncomms15751
    106 schema:sdDatePublished 2021-12-01T19:38
    107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    108 schema:sdPublisher N8370618dc76c44429fbeaefe108f4921
    109 schema:url https://doi.org/10.1038/ncomms15751
    110 sgo:license sg:explorer/license/
    111 sgo:sdDataset articles
    112 rdf:type schema:ScholarlyArticle
    113 N170ebca196a84e359efa5da142ffa000 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Anaphase-Promoting Complex-Cyclosome
    115 rdf:type schema:DefinedTerm
    116 N1efe73e4ccf941dba5c5d9da8f6467a2 rdf:first sg:person.012070570543.37
    117 rdf:rest N67793b6204744f7b99fc4c97e72fa3ce
    118 N1fe68d86aefc4e53b94693acdfd0f3d2 rdf:first sg:person.015065125137.65
    119 rdf:rest N2939a61ab36a4b6c9c11be27cf2a2171
    120 N2172a023535745f0b6d6a43075f85dac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name HeLa Cells
    122 rdf:type schema:DefinedTerm
    123 N2939a61ab36a4b6c9c11be27cf2a2171 rdf:first sg:person.011352415517.80
    124 rdf:rest N5d7a580bf18c4335b2889c6949a7bfdf
    125 N40a27dbb35fa4d45847b3b57b4faf86e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name DNA Breaks, Double-Stranded
    127 rdf:type schema:DefinedTerm
    128 N446a3eb897f04d298d653b8b71b84ee9 schema:name pubmed_id
    129 schema:value 28604711
    130 rdf:type schema:PropertyValue
    131 N4cccbad8dfdd46ab937ebeeba4f43acf rdf:first sg:person.01136627202.11
    132 rdf:rest N1efe73e4ccf941dba5c5d9da8f6467a2
    133 N51393a97cb81413db938e951a182a2b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name HEK293 Cells
    135 rdf:type schema:DefinedTerm
    136 N55954e18c21346c9bccb3273966cec59 schema:name dimensions_id
    137 schema:value pub.1085985067
    138 rdf:type schema:PropertyValue
    139 N5d7a580bf18c4335b2889c6949a7bfdf rdf:first sg:person.01007252565.21
    140 rdf:rest N4cccbad8dfdd46ab937ebeeba4f43acf
    141 N67793b6204744f7b99fc4c97e72fa3ce rdf:first sg:person.011234703267.69
    142 rdf:rest N67b043c586f04d078f709488d783b6df
    143 N67b043c586f04d078f709488d783b6df rdf:first sg:person.01066044464.25
    144 rdf:rest Nc455022c607a4b0a88fd6e987d4a2a1a
    145 N6e4e8d3671b94316a1f49087f709acd5 rdf:first sg:person.0655537451.33
    146 rdf:rest rdf:nil
    147 N6e8d0a57c0594e3995d6a58cde8f727d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Genomic Instability
    149 rdf:type schema:DefinedTerm
    150 N8370618dc76c44429fbeaefe108f4921 schema:name Springer Nature - SN SciGraph project
    151 rdf:type schema:Organization
    152 N8a4ef23ea914491da19cf59f114a4d23 rdf:first sg:person.01245660406.38
    153 rdf:rest Nbbd72d8bad0d4e34bf51724fcfe586f9
    154 N8b7e3632119b49feb662807d7f8115ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Mice
    156 rdf:type schema:DefinedTerm
    157 N8d8dc434aec24e999bb86f78c355e305 rdf:first sg:person.01334165400.51
    158 rdf:rest Na080d3c870f944aeb25a6fc69732d182
    159 N9a817f831b9c4474b764a1e3373a6f00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Signal Transduction
    161 rdf:type schema:DefinedTerm
    162 N9f896f6c819a437192e3b4b7a1e2d1fa rdf:first sg:person.0670442647.31
    163 rdf:rest N8d8dc434aec24e999bb86f78c355e305
    164 Na080d3c870f944aeb25a6fc69732d182 rdf:first sg:person.01066070236.17
    165 rdf:rest N6e4e8d3671b94316a1f49087f709acd5
    166 Na79b17fa4ae7460d96c376059d53cddb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Ubiquitin
    168 rdf:type schema:DefinedTerm
    169 Na972616f959b404e922efd0747b6566a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Models, Genetic
    171 rdf:type schema:DefinedTerm
    172 Nafdf6f25f84b4375b21b4677fc6bf0eb schema:volumeNumber 8
    173 rdf:type schema:PublicationVolume
    174 Nb40e2c7bec3d454d89cdbd08e70982c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Cell Line
    176 rdf:type schema:DefinedTerm
    177 Nbbd72d8bad0d4e34bf51724fcfe586f9 rdf:first sg:person.016416255555.02
    178 rdf:rest Nddaabba9b5964c03ac484d50678b3186
    179 Nc24ee8dc2219482089f7bc8c80369b0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name DNA Repair
    181 rdf:type schema:DefinedTerm
    182 Nc455022c607a4b0a88fd6e987d4a2a1a rdf:first sg:person.0653471144.39
    183 rdf:rest N8a4ef23ea914491da19cf59f114a4d23
    184 Nd54bdbeb178143daa95ef63e02c53101 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Humans
    186 rdf:type schema:DefinedTerm
    187 Nddaabba9b5964c03ac484d50678b3186 rdf:first sg:person.0716321250.19
    188 rdf:rest Ne9e70ff637f449b4a618c5cd8d4264a7
    189 Ne167ae26c7a242ab868a848c3202c7d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Animals
    191 rdf:type schema:DefinedTerm
    192 Ne36c562808d5427d9293e1e003d57838 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name DNA Damage
    194 rdf:type schema:DefinedTerm
    195 Ne9e70ff637f449b4a618c5cd8d4264a7 rdf:first sg:person.013264415067.91
    196 rdf:rest N9f896f6c819a437192e3b4b7a1e2d1fa
    197 Nfe9d81274ef34f7ea1961ed1cdd2fdc2 schema:issueNumber 1
    198 rdf:type schema:PublicationIssue
    199 Nff244bd05f5d4b13baa0513981001464 schema:name doi
    200 schema:value 10.1038/ncomms15751
    201 rdf:type schema:PropertyValue
    202 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    203 schema:name Biological Sciences
    204 rdf:type schema:DefinedTerm
    205 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    206 schema:name Biochemistry and Cell Biology
    207 rdf:type schema:DefinedTerm
    208 sg:grant.2383896 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    209 rdf:type schema:MonetaryGrant
    210 sg:grant.2438696 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    211 rdf:type schema:MonetaryGrant
    212 sg:grant.2438877 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    213 rdf:type schema:MonetaryGrant
    214 sg:grant.2439020 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    215 rdf:type schema:MonetaryGrant
    216 sg:grant.2439241 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    217 rdf:type schema:MonetaryGrant
    218 sg:grant.2478296 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    219 rdf:type schema:MonetaryGrant
    220 sg:grant.2478904 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    221 rdf:type schema:MonetaryGrant
    222 sg:grant.2521795 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    223 rdf:type schema:MonetaryGrant
    224 sg:grant.2674650 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    225 rdf:type schema:MonetaryGrant
    226 sg:grant.2684382 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    227 rdf:type schema:MonetaryGrant
    228 sg:grant.2699254 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    229 rdf:type schema:MonetaryGrant
    230 sg:grant.6978258 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    231 rdf:type schema:MonetaryGrant
    232 sg:grant.7203581 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    233 rdf:type schema:MonetaryGrant
    234 sg:grant.8339064 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    235 rdf:type schema:MonetaryGrant
    236 sg:grant.8342756 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms15751
    237 rdf:type schema:MonetaryGrant
    238 sg:journal.1043282 schema:issn 2041-1723
    239 schema:name Nature Communications
    240 schema:publisher Springer Nature
    241 rdf:type schema:Periodical
    242 sg:person.01007252565.21 schema:affiliation grid-institutes:grid.39382.33
    243 schema:familyName Lin
    244 schema:givenName Han
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007252565.21
    246 rdf:type schema:Person
    247 sg:person.01066044464.25 schema:affiliation grid-institutes:grid.267308.8
    248 schema:familyName Li
    249 schema:givenName Ju-Mei
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066044464.25
    251 rdf:type schema:Person
    252 sg:person.01066070236.17 schema:affiliation grid-institutes:grid.452672.0
    253 schema:familyName Zhu
    254 schema:givenName Qing
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066070236.17
    256 rdf:type schema:Person
    257 sg:person.011234703267.69 schema:affiliation grid-institutes:grid.256607.0
    258 schema:familyName Zhao
    259 schema:givenName Fang
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011234703267.69
    261 rdf:type schema:Person
    262 sg:person.011352415517.80 schema:affiliation grid-institutes:grid.452672.0
    263 schema:familyName Ma
    264 schema:givenName Chengxian
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011352415517.80
    266 rdf:type schema:Person
    267 sg:person.01136627202.11 schema:affiliation grid-institutes:None
    268 schema:familyName Tang
    269 schema:givenName Lichun
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136627202.11
    271 rdf:type schema:Person
    272 sg:person.012070570543.37 schema:affiliation grid-institutes:grid.452438.c
    273 schema:familyName Lian
    274 schema:givenName Zhusheng
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012070570543.37
    276 rdf:type schema:Person
    277 sg:person.01245660406.38 schema:affiliation grid-institutes:None
    278 schema:familyName Pei
    279 schema:givenName Huadong
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245660406.38
    281 rdf:type schema:Person
    282 sg:person.013264415067.91 schema:affiliation grid-institutes:grid.267308.8
    283 schema:familyName Jin
    284 schema:givenName Jianping
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013264415067.91
    286 rdf:type schema:Person
    287 sg:person.01334165400.51 schema:affiliation grid-institutes:grid.256607.0
    288 schema:familyName Zhao
    289 schema:givenName Yongxiang
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334165400.51
    291 rdf:type schema:Person
    292 sg:person.015065125137.65 schema:affiliation grid-institutes:grid.39382.33
    293 schema:familyName Ha
    294 schema:givenName Kyungsoo
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015065125137.65
    296 rdf:type schema:Person
    297 sg:person.016416255555.02 schema:affiliation grid-institutes:grid.452438.c
    298 schema:familyName Han
    299 schema:givenName Suxia
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016416255555.02
    301 rdf:type schema:Person
    302 sg:person.0653471144.39 schema:affiliation grid-institutes:None
    303 schema:familyName Zhen
    304 schema:givenName Bei
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653471144.39
    306 rdf:type schema:Person
    307 sg:person.0655537451.33 schema:affiliation grid-institutes:grid.39382.33
    308 schema:familyName Zhang
    309 schema:givenName Pumin
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655537451.33
    311 rdf:type schema:Person
    312 sg:person.0670442647.31 schema:affiliation grid-institutes:None
    313 schema:familyName Chen
    314 schema:givenName Huan
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670442647.31
    316 rdf:type schema:Person
    317 sg:person.0716321250.19 schema:affiliation grid-institutes:grid.7719.8
    318 schema:familyName Malumbres
    319 schema:givenName Marcos
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716321250.19
    321 rdf:type schema:Person
    322 sg:pub.10.1007/s10911-009-9154-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013912681
    323 https://doi.org/10.1007/s10911-009-9154-4
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/nature08467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052581766
    326 https://doi.org/10.1038/nature08467
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nature08657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046919299
    329 https://doi.org/10.1038/nature08657
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/nature09297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000399358
    332 https://doi.org/10.1038/nature09297
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/nature12318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000270527
    335 https://doi.org/10.1038/nature12318
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/nature15401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052177787
    338 https://doi.org/10.1038/nature15401
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/ncb1212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012198218
    341 https://doi.org/10.1038/ncb1212
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/ncb1742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006184899
    344 https://doi.org/10.1038/ncb1742
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/ncb2092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024640130
    347 https://doi.org/10.1038/ncb2092
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1038/ncb777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000490799
    350 https://doi.org/10.1038/ncb777
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1038/ncomms10201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025922958
    353 https://doi.org/10.1038/ncomms10201
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1038/nrc3916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004022288
    356 https://doi.org/10.1038/nrc3916
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1038/nrm2351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048455891
    359 https://doi.org/10.1038/nrm2351
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1038/nsmb.2188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043148411
    362 https://doi.org/10.1038/nsmb.2188
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1038/nsmb.3072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035141119
    365 https://doi.org/10.1038/nsmb.3072
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1038/onc.2010.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036286393
    368 https://doi.org/10.1038/onc.2010.99
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1038/sj.onc.1206678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026442022
    371 https://doi.org/10.1038/sj.onc.1206678
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1186/1747-1028-4-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025501915
    374 https://doi.org/10.1186/1747-1028-4-2
    375 rdf:type schema:CreativeWork
    376 grid-institutes:None schema:alternateName State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China
    377 schema:name National Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China
    378 State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China
    379 rdf:type schema:Organization
    380 grid-institutes:grid.256607.0 schema:alternateName National Center for International Research of Biological Targeting Diagnosis and Therapy, and Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Guangxi 530021, China
    381 schema:name National Center for International Research of Biological Targeting Diagnosis and Therapy, and Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Guangxi 530021, China
    382 rdf:type schema:Organization
    383 grid-institutes:grid.267308.8 schema:alternateName Department of Biochemistry and Molecular Biology, University of Texas Health Sciences Center, Houston, Texas 77030, USA
    384 schema:name Department of Biochemistry and Molecular Biology, University of Texas Health Sciences Center, Houston, Texas 77030, USA
    385 rdf:type schema:Organization
    386 grid-institutes:grid.39382.33 schema:alternateName Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    387 schema:name Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    388 National Center for Protein Sciences Beijing, Life Sciences Park, Beijing 102206, China
    389 State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China
    390 rdf:type schema:Organization
    391 grid-institutes:grid.452438.c schema:alternateName Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710061, China
    392 schema:name Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710061, China
    393 rdf:type schema:Organization
    394 grid-institutes:grid.452672.0 schema:alternateName Department of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710004, China
    395 schema:name Department of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi 710004, China
    396 rdf:type schema:Organization
    397 grid-institutes:grid.7719.8 schema:alternateName Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid, Spain
    398 schema:name Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid, Spain
    399 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...