Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04-10

AUTHORS

Haiyang Zhang, Ting Deng, Rui Liu, Ming Bai, Likun Zhou, Xia Wang, Shuang Li, Xinyi Wang, Haiou Yang, Jialu Li, Tao Ning, Dingzhi Huang, Hongli Li, Le Zhang, Guoguang Ying, Yi Ba

ABSTRACT

The metastatic organotropism has been one of the cancer's greatest mysteries since the 'seed and soil' hypothesis. Although the role of EGFR in cancer cells is well studied, the effects of secreted EGFR transported by exosomes are less understood. Here we show that EGFR in exosomes secreted from gastric cancer cells can be delivered into the liver and is integrated on the plasma membrane of liver stromal cells. The translocated EGFR is proved to effectively activate hepatocyte growth factor (HGF) by suppressing miR-26a/b expression. Moreover, the upregulated paracrine HGF, which binds the c-MET receptor on the migrated cancer cells, provides fertile 'soil' for the 'seed', facilitating the landing and proliferation of metastatic cancer cells. Thus, we propose that EGFR-containing exosomes derived from cancer cells could favour the development of a liver-like microenvironment promoting liver-specific metastasis. More... »

PAGES

15016

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms15016

    DOI

    http://dx.doi.org/10.1038/ncomms15016

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084742220

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28393839


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