Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-01

AUTHORS

Martin S Davey, Carrie R Willcox, Stephen P Joyce, Kristin Ladell, Sofya A Kasatskaya, James E McLaren, Stuart Hunter, Mahboob Salim, Fiyaz Mohammed, David A Price, Dmitriy M Chudakov, Benjamin E Willcox

ABSTRACT

γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, Vδ2+ T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human Vδ1+ T cells have therefore evolved a distinct biology from the Vδ2+ subset, involving a central, personalized role for the γδ TCR in directing a highly adaptive yet unconventional form of immune surveillance. More... »

PAGES

14760

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms14760

DOI

http://dx.doi.org/10.1038/ncomms14760

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084128972

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28248310


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CX3C Chemokine Receptor 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clone Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complementarity Determining Regions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytotoxicity, Immunologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunologic Surveillance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-15", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Antigen, T-Cell, gamma-delta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Donors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor Receptor Superfamily, Member 7", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Cancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davey", 
        "givenName": "Martin S", 
        "id": "sg:person.0636750277.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636750277.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Cancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Willcox", 
        "givenName": "Carrie R", 
        "id": "sg:person.01077233042.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077233042.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Cancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joyce", 
        "givenName": "Stephen P", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ladell", 
        "givenName": "Kristin", 
        "id": "sg:person.0705151145.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705151145.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central European Institute of Technology \u2013 Masaryk University", 
          "id": "https://www.grid.ac/institutes/grid.497421.d", 
          "name": [
            "Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow 117997, Russia.", 
            "Pirogov Russian National Research Medical University, Moscow 117997, Russia.", 
            "Central European Institute of Technology, Masaryk University, Brno 625 00, Czech Republic."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kasatskaya", 
        "givenName": "Sofya A", 
        "id": "sg:person.0773731637.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773731637.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "McLaren", 
        "givenName": "James E", 
        "id": "sg:person.0717355204.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717355204.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Cancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hunter", 
        "givenName": "Stuart", 
        "id": "sg:person.01226455061.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226455061.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Cancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salim", 
        "givenName": "Mahboob", 
        "id": "sg:person.0631323410.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631323410.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Cancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mohammed", 
        "givenName": "Fiyaz", 
        "id": "sg:person.01354727510.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354727510.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Price", 
        "givenName": "David A", 
        "id": "sg:person.011306064612.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011306064612.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central European Institute of Technology \u2013 Masaryk University", 
          "id": "https://www.grid.ac/institutes/grid.497421.d", 
          "name": [
            "Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow 117997, Russia.", 
            "Pirogov Russian National Research Medical University, Moscow 117997, Russia.", 
            "Central European Institute of Technology, Masaryk University, Brno 625 00, Czech Republic."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chudakov", 
        "givenName": "Dmitriy M", 
        "id": "sg:person.014526463460.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014526463460.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Cancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Willcox", 
        "givenName": "Benjamin E", 
        "id": "sg:person.01176227010.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176227010.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.4049/jimmunol.1000231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005867248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci5409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006164589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.2394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006653799", 
          "https://doi.org/10.1038/ni.2394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.2394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006653799", 
          "https://doi.org/10.1038/ni.2394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2013.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006759826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20030235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008032220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.09083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008412954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010014687", 
          "https://doi.org/10.1038/nri3384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.2007.03388.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010835078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.2713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011079620", 
          "https://doi.org/10.1038/ni.2713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.189.12.1907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011609369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200939222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013653249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014219529", 
          "https://doi.org/10.1038/nri2781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014219529", 
          "https://doi.org/10.1038/nri2781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2005.07.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014369076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2005.07.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014369076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200425837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015136612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.180.3.1171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015273413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2009.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016266241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.179.1.323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016985351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20090348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017954211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cei.12297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020614181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/644509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023735744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0913939107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025470425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1412058112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026556000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028482996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bth945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028858088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20030050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031316613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2012.06.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032389822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1202940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035610689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035641311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2013.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035723620", 
          "https://doi.org/10.1038/bmt.2013.75"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.01762-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036883497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.2773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037969525", 
          "https://doi.org/10.1038/ni.2773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms7477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038752857", 
          "https://doi.org/10.1038/ncomms7477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/icb.2014.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038772145", 
          "https://doi.org/10.1038/icb.2014.91"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/v4102379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039401252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2006.00479.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039681593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.20433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043440145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2012.00299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044508246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-immunol-032713-120216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044549575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-01-136713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045023927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045160858", 
          "https://doi.org/10.1038/nri2436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1004503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045762173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.18.1.975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046362106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-02-339135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047321484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-immunol-041015-055435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047800138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050236486", 
          "https://doi.org/10.1038/nri2260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.3364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050340546", 
          "https://doi.org/10.1038/nmeth.3364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/msb.2011.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053089433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/msb.2011.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053089433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.186.9.1407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058438620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/pdb.prot5634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060411449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3002536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062687096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2008101072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068243283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2008101072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068243283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2008101072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068243283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074517452", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.4.1984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075101467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081986629", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082693294", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-03-01", 
    "datePublishedReg": "2017-03-01", 
    "description": "\u03b3\u03b4 T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human V\u03b42neg T cells, implicated in responses to viral infection and cancer. The prevalent V\u03b41 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, V\u03b42+ T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human V\u03b41+ T cells have therefore evolved a distinct biology from the V\u03b42+ subset, involving a central, personalized role for the \u03b3\u03b4 TCR in directing a highly adaptive yet unconventional form of immune surveillance.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms14760", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3640095", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2787277", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4896148", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Clonal selection in the human V\u03b41 T cell repertoire indicates \u03b3\u03b4 TCR-dependent adaptive immune surveillance", 
    "pagination": "14760", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b72044fe2371097e59b64dfb05bba42093b56b4159ed34dc57b389ad992a44ff"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28248310"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms14760"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084128972"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms14760", 
      "https://app.dimensions.ai/details/publication/pub.1084128972"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000608.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ncomms/2017/170301/ncomms14760/full/ncomms14760.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms14760'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms14760'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms14760'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms14760'


 

This table displays all metadata directly associated to this object as RDF triples.

392 TRIPLES      21 PREDICATES      98 URIs      35 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms14760 schema:about N1285a475a7be4e7086970b58034f2e1e
2 N1e11cda5512147ff9155c96ecdbf42e5
3 N408aa3e83da9426e9aa9a50fcd34faf4
4 N421518e37c39423fa2d6602f91bcdab4
5 N6b272e2b6fe0417a8c298c93e6868bb2
6 N7ae064dc1c934229813c09490a27c45e
7 N8f24b1c6f15d48348966d406e5667b1b
8 Nace17a84f0114a49b5f5e2b57a97ab0d
9 Nb85675e4992940b48c82c6177c2528dc
10 Nd333f8d039c0414a814bce4fe3c354a1
11 Nd59ce92a909a4cfa8d9c53900700f40a
12 Nd632d5dc110242e3849aa6a87990860e
13 Ndf6796a17cd3418ea0ca9650d7215f32
14 Ne5936b3d9cb64d45a54196e4b0535359
15 Nf58fef6765714366a2d5e92cfd640afe
16 Nf65a8a5efc4942819cbef05d60e3ea5d
17 anzsrc-for:11
18 anzsrc-for:1107
19 schema:author N283c86b0435a481d9764bd6d67145e76
20 schema:citation sg:pub.10.1038/bmt.2013.75
21 sg:pub.10.1038/icb.2014.91
22 sg:pub.10.1038/ncomms7477
23 sg:pub.10.1038/ni.2394
24 sg:pub.10.1038/ni.2713
25 sg:pub.10.1038/ni.2773
26 sg:pub.10.1038/nmeth.3364
27 sg:pub.10.1038/nri2260
28 sg:pub.10.1038/nri2436
29 sg:pub.10.1038/nri2781
30 sg:pub.10.1038/nri3384
31 https://app.dimensions.ai/details/publication/pub.1074517452
32 https://app.dimensions.ai/details/publication/pub.1081986629
33 https://app.dimensions.ai/details/publication/pub.1082693294
34 https://doi.org/10.1002/eji.200425837
35 https://doi.org/10.1002/eji.200939222
36 https://doi.org/10.1002/hep.20433
37 https://doi.org/10.1016/j.coi.2005.07.019
38 https://doi.org/10.1016/j.immuni.2009.08.006
39 https://doi.org/10.1016/j.immuni.2012.06.011
40 https://doi.org/10.1016/j.immuni.2013.11.001
41 https://doi.org/10.1038/msb.2011.75
42 https://doi.org/10.1073/pnas.0913939107
43 https://doi.org/10.1073/pnas.1412058112
44 https://doi.org/10.1084/jem.179.1.323
45 https://doi.org/10.1084/jem.180.3.1171
46 https://doi.org/10.1084/jem.186.9.1407
47 https://doi.org/10.1084/jem.189.12.1907
48 https://doi.org/10.1084/jem.20030050
49 https://doi.org/10.1084/jem.20030235
50 https://doi.org/10.1084/jem.20041851
51 https://doi.org/10.1084/jem.20090348
52 https://doi.org/10.1086/644509
53 https://doi.org/10.1093/bioinformatics/bth945
54 https://doi.org/10.1093/nar/gks469
55 https://doi.org/10.1101/pdb.prot5634
56 https://doi.org/10.1111/cei.12297
57 https://doi.org/10.1111/j.1365-2249.2007.03388.x
58 https://doi.org/10.1111/j.1600-065x.2006.00479.x
59 https://doi.org/10.1126/scitranslmed.3002536
60 https://doi.org/10.1128/jcm.01762-06
61 https://doi.org/10.1146/annurev-immunol-032713-120216
62 https://doi.org/10.1146/annurev-immunol-041015-055435
63 https://doi.org/10.1146/annurev.immunol.18.1.975
64 https://doi.org/10.1172/jci5409
65 https://doi.org/10.1182/blood-2008-01-136713
66 https://doi.org/10.1182/blood-2011-02-339135
67 https://doi.org/10.1371/journal.pcbi.1004503
68 https://doi.org/10.1681/asn.2008101072
69 https://doi.org/10.3389/fimmu.2012.00299
70 https://doi.org/10.3390/v4102379
71 https://doi.org/10.4049/jimmunol.1000231
72 https://doi.org/10.4049/jimmunol.1202940
73 https://doi.org/10.4049/jimmunol.169.4.1984
74 https://doi.org/10.7554/elife.09083
75 schema:datePublished 2017-03-01
76 schema:datePublishedReg 2017-03-01
77 schema:description γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2<sup>neg</sup> T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, Vδ2<sup>+</sup> T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human Vδ1<sup>+</sup> T cells have therefore evolved a distinct biology from the Vδ2<sup>+</sup> subset, involving a central, personalized role for the γδ TCR in directing a highly adaptive yet unconventional form of immune surveillance.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree true
81 schema:isPartOf N46b0742881934ab887e1ba5d101ea197
82 sg:journal.1043282
83 schema:name Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance
84 schema:pagination 14760
85 schema:productId N3666f1cf989b4092b1d2a1aa3a29ad9c
86 Nc6237bfc9df84a0aa25445df15521608
87 Nc7ad377ddfda463d877a52a4b0759f24
88 Nd01fce2643c24457acbc387cb29595ce
89 Nd783e536356f470eb0617278fb0766e7
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128972
91 https://doi.org/10.1038/ncomms14760
92 schema:sdDatePublished 2019-04-10T18:33
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N12d59c046ff54f0aa89a9496288c5765
95 schema:url http://www.nature.com/ncomms/2017/170301/ncomms14760/full/ncomms14760.html
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N0dfd5da30fda45daa74b434a9d2540e9 rdf:first sg:person.011306064612.17
100 rdf:rest N37fecdf4044d4501878ca1f3556c5f16
101 N1285a475a7be4e7086970b58034f2e1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Cytotoxicity, Immunologic
103 rdf:type schema:DefinedTerm
104 N12d59c046ff54f0aa89a9496288c5765 schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N1e11cda5512147ff9155c96ecdbf42e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cell Differentiation
108 rdf:type schema:DefinedTerm
109 N283c86b0435a481d9764bd6d67145e76 rdf:first sg:person.0636750277.01
110 rdf:rest Nc6f5a6b2d4814250a20fc450465b1f8d
111 N2e3ca57622de4c9b82f1521047c2acde rdf:first sg:person.01354727510.88
112 rdf:rest N0dfd5da30fda45daa74b434a9d2540e9
113 N3666f1cf989b4092b1d2a1aa3a29ad9c schema:name nlm_unique_id
114 schema:value 101528555
115 rdf:type schema:PropertyValue
116 N37fecdf4044d4501878ca1f3556c5f16 rdf:first sg:person.014526463460.22
117 rdf:rest Nd3c09f5806ce42079794a22f651324b4
118 N408aa3e83da9426e9aa9a50fcd34faf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Tumor Necrosis Factor Receptor Superfamily, Member 7
120 rdf:type schema:DefinedTerm
121 N421518e37c39423fa2d6602f91bcdab4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Immunologic Surveillance
123 rdf:type schema:DefinedTerm
124 N46b0742881934ab887e1ba5d101ea197 schema:volumeNumber 8
125 rdf:type schema:PublicationVolume
126 N6b272e2b6fe0417a8c298c93e6868bb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name CX3C Chemokine Receptor 1
128 rdf:type schema:DefinedTerm
129 N75c4ef5b73a64733ab667c116a5d2388 rdf:first sg:person.01226455061.55
130 rdf:rest Ne38bd5474b164f498676fb30b33b52db
131 N7ae064dc1c934229813c09490a27c45e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Interleukin-15
133 rdf:type schema:DefinedTerm
134 N856f668ba2274c02a5d007933eacbd8a rdf:first sg:person.0773731637.43
135 rdf:rest N8ad7365f629840d88f8c1cd6c8a1cbc2
136 N8ad7365f629840d88f8c1cd6c8a1cbc2 rdf:first sg:person.0717355204.38
137 rdf:rest N75c4ef5b73a64733ab667c116a5d2388
138 N8f24b1c6f15d48348966d406e5667b1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Genetic Variation
140 rdf:type schema:DefinedTerm
141 N9800df9230334d7ea2fa16bda2806ca4 rdf:first Nfa17b35f8ac24991bce717cba3899a12
142 rdf:rest Nc258616dbd084db6acbd883068a988ed
143 Nace17a84f0114a49b5f5e2b57a97ab0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Phenotype
145 rdf:type schema:DefinedTerm
146 Nb85675e4992940b48c82c6177c2528dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Biomarkers
148 rdf:type schema:DefinedTerm
149 Nc258616dbd084db6acbd883068a988ed rdf:first sg:person.0705151145.54
150 rdf:rest N856f668ba2274c02a5d007933eacbd8a
151 Nc6237bfc9df84a0aa25445df15521608 schema:name doi
152 schema:value 10.1038/ncomms14760
153 rdf:type schema:PropertyValue
154 Nc6f5a6b2d4814250a20fc450465b1f8d rdf:first sg:person.01077233042.65
155 rdf:rest N9800df9230334d7ea2fa16bda2806ca4
156 Nc7ad377ddfda463d877a52a4b0759f24 schema:name pubmed_id
157 schema:value 28248310
158 rdf:type schema:PropertyValue
159 Nd01fce2643c24457acbc387cb29595ce schema:name dimensions_id
160 schema:value pub.1084128972
161 rdf:type schema:PropertyValue
162 Nd333f8d039c0414a814bce4fe3c354a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Humans
164 rdf:type schema:DefinedTerm
165 Nd3c09f5806ce42079794a22f651324b4 rdf:first sg:person.01176227010.30
166 rdf:rest rdf:nil
167 Nd59ce92a909a4cfa8d9c53900700f40a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Tissue Donors
169 rdf:type schema:DefinedTerm
170 Nd632d5dc110242e3849aa6a87990860e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Receptors, Antigen, T-Cell, gamma-delta
172 rdf:type schema:DefinedTerm
173 Nd783e536356f470eb0617278fb0766e7 schema:name readcube_id
174 schema:value b72044fe2371097e59b64dfb05bba42093b56b4159ed34dc57b389ad992a44ff
175 rdf:type schema:PropertyValue
176 Ndf6796a17cd3418ea0ca9650d7215f32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Complementarity Determining Regions
178 rdf:type schema:DefinedTerm
179 Ne38bd5474b164f498676fb30b33b52db rdf:first sg:person.0631323410.32
180 rdf:rest N2e3ca57622de4c9b82f1521047c2acde
181 Ne5936b3d9cb64d45a54196e4b0535359 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Cell Proliferation
183 rdf:type schema:DefinedTerm
184 Nf58fef6765714366a2d5e92cfd640afe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Clone Cells
186 rdf:type schema:DefinedTerm
187 Nf65a8a5efc4942819cbef05d60e3ea5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Adult
189 rdf:type schema:DefinedTerm
190 Nfa17b35f8ac24991bce717cba3899a12 schema:affiliation https://www.grid.ac/institutes/grid.6572.6
191 schema:familyName Joyce
192 schema:givenName Stephen P
193 rdf:type schema:Person
194 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
195 schema:name Medical and Health Sciences
196 rdf:type schema:DefinedTerm
197 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
198 schema:name Immunology
199 rdf:type schema:DefinedTerm
200 sg:grant.2787277 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms14760
201 rdf:type schema:MonetaryGrant
202 sg:grant.3640095 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms14760
203 rdf:type schema:MonetaryGrant
204 sg:grant.4896148 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms14760
205 rdf:type schema:MonetaryGrant
206 sg:journal.1043282 schema:issn 2041-1723
207 schema:name Nature Communications
208 rdf:type schema:Periodical
209 sg:person.01077233042.65 schema:affiliation https://www.grid.ac/institutes/grid.6572.6
210 schema:familyName Willcox
211 schema:givenName Carrie R
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077233042.65
213 rdf:type schema:Person
214 sg:person.011306064612.17 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
215 schema:familyName Price
216 schema:givenName David A
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011306064612.17
218 rdf:type schema:Person
219 sg:person.01176227010.30 schema:affiliation https://www.grid.ac/institutes/grid.6572.6
220 schema:familyName Willcox
221 schema:givenName Benjamin E
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176227010.30
223 rdf:type schema:Person
224 sg:person.01226455061.55 schema:affiliation https://www.grid.ac/institutes/grid.6572.6
225 schema:familyName Hunter
226 schema:givenName Stuart
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226455061.55
228 rdf:type schema:Person
229 sg:person.01354727510.88 schema:affiliation https://www.grid.ac/institutes/grid.6572.6
230 schema:familyName Mohammed
231 schema:givenName Fiyaz
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354727510.88
233 rdf:type schema:Person
234 sg:person.014526463460.22 schema:affiliation https://www.grid.ac/institutes/grid.497421.d
235 schema:familyName Chudakov
236 schema:givenName Dmitriy M
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014526463460.22
238 rdf:type schema:Person
239 sg:person.0631323410.32 schema:affiliation https://www.grid.ac/institutes/grid.6572.6
240 schema:familyName Salim
241 schema:givenName Mahboob
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631323410.32
243 rdf:type schema:Person
244 sg:person.0636750277.01 schema:affiliation https://www.grid.ac/institutes/grid.6572.6
245 schema:familyName Davey
246 schema:givenName Martin S
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636750277.01
248 rdf:type schema:Person
249 sg:person.0705151145.54 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
250 schema:familyName Ladell
251 schema:givenName Kristin
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705151145.54
253 rdf:type schema:Person
254 sg:person.0717355204.38 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
255 schema:familyName McLaren
256 schema:givenName James E
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717355204.38
258 rdf:type schema:Person
259 sg:person.0773731637.43 schema:affiliation https://www.grid.ac/institutes/grid.497421.d
260 schema:familyName Kasatskaya
261 schema:givenName Sofya A
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773731637.43
263 rdf:type schema:Person
264 sg:pub.10.1038/bmt.2013.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035723620
265 https://doi.org/10.1038/bmt.2013.75
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/icb.2014.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038772145
268 https://doi.org/10.1038/icb.2014.91
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/ncomms7477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038752857
271 https://doi.org/10.1038/ncomms7477
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/ni.2394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006653799
274 https://doi.org/10.1038/ni.2394
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/ni.2713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011079620
277 https://doi.org/10.1038/ni.2713
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/ni.2773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037969525
280 https://doi.org/10.1038/ni.2773
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nmeth.3364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050340546
283 https://doi.org/10.1038/nmeth.3364
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nri2260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050236486
286 https://doi.org/10.1038/nri2260
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nri2436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045160858
289 https://doi.org/10.1038/nri2436
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nri2781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014219529
292 https://doi.org/10.1038/nri2781
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nri3384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010014687
295 https://doi.org/10.1038/nri3384
296 rdf:type schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1074517452 schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1081986629 schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1082693294 schema:CreativeWork
300 https://doi.org/10.1002/eji.200425837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015136612
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1002/eji.200939222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013653249
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1002/hep.20433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043440145
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.coi.2005.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014369076
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.immuni.2009.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016266241
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.immuni.2012.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032389822
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.immuni.2013.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006759826
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1038/msb.2011.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053089433
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1073/pnas.0913939107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025470425
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1073/pnas.1412058112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026556000
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1084/jem.179.1.323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016985351
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1084/jem.180.3.1171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015273413
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1084/jem.186.9.1407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058438620
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1084/jem.189.12.1907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011609369
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1084/jem.20030050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031316613
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1084/jem.20030235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008032220
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1084/jem.20041851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035641311
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1084/jem.20090348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017954211
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1086/644509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023735744
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/bioinformatics/bth945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028858088
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1093/nar/gks469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028482996
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1101/pdb.prot5634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060411449
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1111/cei.12297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020614181
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1111/j.1365-2249.2007.03388.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010835078
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1111/j.1600-065x.2006.00479.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039681593
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1126/scitranslmed.3002536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062687096
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1128/jcm.01762-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036883497
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1146/annurev-immunol-032713-120216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044549575
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1146/annurev-immunol-041015-055435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047800138
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1146/annurev.immunol.18.1.975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046362106
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1172/jci5409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006164589
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1182/blood-2008-01-136713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045023927
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1182/blood-2011-02-339135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047321484
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1371/journal.pcbi.1004503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045762173
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1681/asn.2008101072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068243283
369 rdf:type schema:CreativeWork
370 https://doi.org/10.3389/fimmu.2012.00299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044508246
371 rdf:type schema:CreativeWork
372 https://doi.org/10.3390/v4102379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039401252
373 rdf:type schema:CreativeWork
374 https://doi.org/10.4049/jimmunol.1000231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005867248
375 rdf:type schema:CreativeWork
376 https://doi.org/10.4049/jimmunol.1202940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035610689
377 rdf:type schema:CreativeWork
378 https://doi.org/10.4049/jimmunol.169.4.1984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075101467
379 rdf:type schema:CreativeWork
380 https://doi.org/10.7554/elife.09083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008412954
381 rdf:type schema:CreativeWork
382 https://www.grid.ac/institutes/grid.497421.d schema:alternateName Central European Institute of Technology – Masaryk University
383 schema:name Central European Institute of Technology, Masaryk University, Brno 625 00, Czech Republic.
384 Pirogov Russian National Research Medical University, Moscow 117997, Russia.
385 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow 117997, Russia.
386 rdf:type schema:Organization
387 https://www.grid.ac/institutes/grid.5600.3 schema:alternateName Cardiff University
388 schema:name Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
389 rdf:type schema:Organization
390 https://www.grid.ac/institutes/grid.6572.6 schema:alternateName University of Birmingham
391 schema:name Cancer Immunology and Immunotherapy Centre, Institute for Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
392 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...