Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-01

AUTHORS

Martin S Davey, Carrie R Willcox, Stephen P Joyce, Kristin Ladell, Sofya A Kasatskaya, James E McLaren, Stuart Hunter, Mahboob Salim, Fiyaz Mohammed, David A Price, Dmitriy M Chudakov, Benjamin E Willcox

ABSTRACT

γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, Vδ2+ T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human Vδ1+ T cells have therefore evolved a distinct biology from the Vδ2+ subset, involving a central, personalized role for the γδ TCR in directing a highly adaptive yet unconventional form of immune surveillance. More... »

PAGES

14760

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms14760

DOI

http://dx.doi.org/10.1038/ncomms14760

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084128972

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28248310


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