Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-02-09

AUTHORS

Nikaïa Smith, Nicolas Pietrancosta, Sophia Davidson, Jacques Dutrieux, Lise Chauveau, Pasquale Cutolo, Michel Dy, Daniel Scott-Algara, Bénédicte Manoury, Onofrio Zirafi, Isabelle McCort-Tranchepain, Thierry Durroux, Françoise Bachelerie, Olivier Schwartz, Jan Münch, Andreas Wack, Sébastien Nisole, Jean-Philippe Herbeuval

ABSTRACT

Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential. More... »

PAGES

14253

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms14253

DOI

http://dx.doi.org/10.1038/ncomms14253

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083736536

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28181493


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