mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-01-27

AUTHORS

R. W. Hallowell, S. L. Collins, J. M. Craig, Y. Zhang, M. Oh, P. B. Illei, Y. Chan-Li, C. L. Vigeland, W. Mitzner, A. L. Scott, J. D. Powell, M. R. Horton

ABSTRACT

Alternatively activated macrophages (M2) have an important function in innate immune responses to parasitic helminths, and emerging evidence also indicates these cells are regulators of systemic metabolism. Here we show a critical role for mTORC2 signalling in the generation of M2 macrophages. Abrogation of mTORC2 signalling in macrophages by selective conditional deletion of the adaptor molecule Rictor inhibits the generation of M2 macrophages while leaving the generation of classically activated macrophages (M1) intact. Selective deletion of Rictor in macrophages prevents M2 differentiation and clearance of a parasitic helminth infection in mice, and also abrogates the ability of mice to regulate brown fat and maintain core body temperature. Our findings define a role for mTORC2 in macrophages in integrating signals from the immune microenvironment to promote innate type 2 immunity, and also to integrate systemic metabolic and thermogenic responses. More... »

PAGES

14208

References to SciGraph publications

  • 2002-09. PI3K-mediated negative feedback regulation of IL-12 production in DCs in NATURE IMMUNOLOGY
  • 2011-11-20. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis in NATURE
  • 2014-12. The mTOR kinase inhibitors polarize glioma-activated microglia to express a M1 phenotype in JOURNAL OF NEUROINFLAMMATION
  • 2013-12. The TSC-mTOR pathway regulates macrophage polarization in NATURE COMMUNICATIONS
  • 1994-06. A mammalian protein targeted by G1-arresting rapamycin–receptor complex in NATURE
  • 2015-10. Regulation of innate immune cell function by mTOR in NATURE REVIEWS IMMUNOLOGY
  • 2009-03. Pulmonary fibrosis: pathogenesis, etiology and regulation in MUCOSAL IMMUNOLOGY
  • 2014-08-31. Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion in NATURE IMMUNOLOGY
  • 1999-08. Conditional gene targeting in macrophages and granulocytes using LysMcre mice in TRANSGENIC RESEARCH
  • 2011-04. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2 in NATURE IMMUNOLOGY
  • 2014-12. TSC1 controls macrophage polarization to prevent inflammatory disease in NATURE COMMUNICATIONS
  • 2016-03. Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice in DIABETOLOGIA
  • 1996-02. The role of macrophage subpopulations in autoimmune disease of the central nervous system in JOURNAL OF MOLECULAR HISTOLOGY
  • 2009. Analyzing Classical and Alternative Macrophage Activation in Macrophage/Neutrophil-Specific IL-4 Receptor-Alpha-Deficient Mice in MACROPHAGES AND DENDRITIC CELLS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms14208

    DOI

    http://dx.doi.org/10.1038/ncomms14208

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1074227532

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28128208


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