The complete structure of an activated open sodium channel View Full Text


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Article Info

DATE

2017-02-16

AUTHORS

Altin Sula, Jennifer Booker, Leo C T Ng, Claire E Naylor, Paul G DeCaen, B A Wallace

ABSTRACT

Voltage-gated sodium channels (Navs) play essential roles in excitable tissues, with their activation and opening resulting in the initial phase of the action potential. The cycling of Navs through open, closed and inactivated states, and their closely choreographed relationships with the activities of other ion channels lead to exquisite control of intracellular ion concentrations in both prokaryotes and eukaryotes. Here we present the 2.45 Å resolution crystal structure of the complete NavMs prokaryotic sodium channel in a fully open conformation. A canonical activated conformation of the voltage sensor S4 helix, an open selectivity filter leading to an open activation gate at the intracellular membrane surface and the intracellular C-terminal domain are visible in the structure. It includes a heretofore unseen interaction motif between W77 of S3, the S4-S5 interdomain linker, and the C-terminus, which is associated with regulation of opening and closing of the intracellular gate. More... »

PAGES

14205

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms14205

DOI

http://dx.doi.org/10.1038/ncomms14205

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083843179

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28205548


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