Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-20

AUTHORS

Michael J. Mitchell, Jamie Webster, Amanda Chung, Pedro P. G. Guimarães, Omar F. Khan, Robert Langer

ABSTRACT

Physical forces affect tumour growth, progression and metastasis. Here, we develop polymeric mechanical amplifiers that exploit in vitro and in vivo physical forces to increase immune cytokine-mediated tumour cell apoptosis. Mechanical amplifiers, consisting of biodegradable polymeric particles tethered to the tumour cell surface via polyethylene glycol linkers, increase the apoptotic effect of an immune cytokine on tumour cells under fluid shear exposure by as much as 50% compared with treatment under static conditions. We show that targeted polymeric particles delivered to tumour cells in vivo amplify the apoptotic effect of a subsequent treatment of immune cytokine, reduce circulating tumour cells in blood and overall tumour cell burden by over 90% and reduce solid tumour growth in combination with the antioxidant resveratrol. The work introduces a potentially new application for a broad range of micro- and nanoparticles to maximize receptor-mediated signalling and function in the presence of physical forces. More... »

PAGES

14179

References to SciGraph publications

  • 2011-07. The physics of cancer: the role of physical interactions and mechanical forces in metastasis in NATURE REVIEWS CANCER
  • 2007-12. Nanocarriers as an emerging platform for cancer therapy in NATURE NANOTECHNOLOGY
  • 2010-08. New insights into apoptosis signaling by Apo2L/TRAIL in ONCOGENE
  • 2009-02. A tense situation: forcing tumour progression in NATURE REVIEWS CANCER
  • 2012-12. A magnetic switch for the control of cell death signalling in in vitro and in vivo systems in NATURE MATERIALS
  • 2015-09. Piperlongumine and immune cytokine TRAIL synergize to promote tumor death in SCIENTIFIC REPORTS
  • 2002-10. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFκB activation in epithelial derived cell lines in APOPTOSIS
  • 2008-09. A Balance of Substrate Mechanics and Matrix Chemistry Regulates Endothelial Cell Network Assembly in CELLULAR AND MOLECULAR BIOENGINEERING
  • 2009-01. Mechanotransduction in vascular physiology and atherogenesis in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-11. Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch in NATURE
  • 2013-03. On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics in ONCOGENE
  • 2012-11. Ultrasensitive detection of toxic cations through changes in the tunnelling current across films of striped nanoparticles in NATURE MATERIALS
  • 2008-01. Nanomagnetic actuation of receptor-mediated signal transduction in NATURE NANOTECHNOLOGY
  • 2004-04. Designing materials for biology and medicine in NATURE
  • 2005-03. Mechanisms of resistance to TRAIL-induced apoptosis in cancer in CANCER GENE THERAPY
  • 2015-12. Hetero-modification of TRAIL trimer for improved drug delivery and in vivo antitumor activities in SCIENTIFIC REPORTS
  • 2012-03. Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity in NATURE REVIEWS CANCER
  • 2011-07. Dynamic molecular processes mediate cellular mechanotransduction in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms14179

    DOI

    http://dx.doi.org/10.1038/ncomms14179

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084128789

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28317839


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Evaluation, Preclinical", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Synergism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HT29 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Targeted Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nanoparticles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polyethylene Glycols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stress, Mechanical", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "TNF-Related Apoptosis-Inducing Ligand", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Department of Chemical Engineering, David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts 02139, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mitchell", 
            "givenName": "Michael J.", 
            "id": "sg:person.0637421331.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637421331.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Department of Chemical Engineering, David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts 02139, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Webster", 
            "givenName": "Jamie", 
            "id": "sg:person.010405047175.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010405047175.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Department of Chemical Engineering, David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts 02139, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chung", 
            "givenName": "Amanda", 
            "id": "sg:person.012244144163.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012244144163.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Department of Chemical Engineering, David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts 02139, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guimar\u00e3es", 
            "givenName": "Pedro P. G.", 
            "id": "sg:person.01204756503.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204756503.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Department of Chemical Engineering, David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts 02139, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Khan", 
            "givenName": "Omar F.", 
            "id": "sg:person.01012772034.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012772034.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Department of Chemical Engineering, David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts 02139, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Langer", 
            "givenName": "Robert", 
            "id": "sg:person.01117537642.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117537642.02"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.bpj.2014.12.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000987319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijpharm.2005.10.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001767435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004484652", 
              "https://doi.org/10.1038/nature10316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004484652", 
              "https://doi.org/10.1038/nature10316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004484652", 
              "https://doi.org/10.1038/nature10316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2006.03.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005479285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005911953", 
              "https://doi.org/10.1038/nature02388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005911953", 
              "https://doi.org/10.1038/nature02388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005911953", 
              "https://doi.org/10.1038/nature02388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006330641", 
              "https://doi.org/10.1038/onc.2012.164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdf441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007465513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1103581108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008096838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20031253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009110644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20031253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009110644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201001149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009679551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201001149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009679551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013800595", 
              "https://doi.org/10.1038/nrc3186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.00285.2013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016226893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat3430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017108578", 
              "https://doi.org/10.1038/nmat3430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2544", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017337522", 
              "https://doi.org/10.1038/nrc2544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3495(04)74136-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017503368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3495(01)76090-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018303818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biomaterials.2011.01.054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020338251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci80420", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022292043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023540354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0015627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025164198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2014.07.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026191653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198107163050305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027347222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fonc.2013.00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029085281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2596", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030218920", 
              "https://doi.org/10.1038/nrm2596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbm.a.35445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030225057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bpj.2014.04.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030581600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep14872", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030735815", 
              "https://doi.org/10.1038/srep14872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc500427g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033606320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034314308", 
              "https://doi.org/10.1038/nrc3080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nnano.2007.387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034703917", 
              "https://doi.org/10.1038/nnano.2007.387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat3406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035953857", 
              "https://doi.org/10.1038/nmat3406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.15.7198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037648394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b912438a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038357785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.183699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038492099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)00112-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039444748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.200805179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040015698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.200805179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040015698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12195-008-0022-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042424752", 
              "https://doi.org/10.1007/s12195-008-0022-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.bioeng.9.060906.151850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042643673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci34359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043005792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fonc.2013.00044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043236405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043860701", 
              "https://doi.org/10.1038/onc.2010.221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043860701", 
              "https://doi.org/10.1038/onc.2010.221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7700792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044033045", 
              "https://doi.org/10.1038/sj.cgt.7700792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cgt.7700792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044033045", 
              "https://doi.org/10.1038/sj.cgt.7700792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep09987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044835586", 
              "https://doi.org/10.1038/srep09987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1106587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045265288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1020031023947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046987267", 
              "https://doi.org/10.1023/a:1020031023947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-05-0262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048492521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2005.05.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048568319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejpb.2008.09.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049562052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nnano.2007.418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049627546", 
              "https://doi.org/10.1038/nnano.2007.418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp800051m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050269388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp800051m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050269388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050531578", 
              "https://doi.org/10.1038/nature06254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1316312111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053170268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/nl802689k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056221573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/nl802689k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056221573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1088/1367-2630/15/1/015008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059135919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/57.5.1199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074254624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074573419", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074882356", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076844165", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077406153", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078733618", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079921416", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083258120", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-03-20", 
        "datePublishedReg": "2017-03-20", 
        "description": "Physical forces affect tumour growth, progression and metastasis. Here, we develop polymeric mechanical amplifiers that exploit in vitro and in vivo physical forces to increase immune cytokine-mediated tumour cell apoptosis. Mechanical amplifiers, consisting of biodegradable polymeric particles tethered to the tumour cell surface via polyethylene glycol linkers, increase the apoptotic effect of an immune cytokine on tumour cells under fluid shear exposure by as much as 50% compared with treatment under static conditions. We show that targeted polymeric particles delivered to tumour cells in vivo amplify the apoptotic effect of a subsequent treatment of immune cytokine, reduce circulating tumour cells in blood and overall tumour cell burden by over 90% and reduce solid tumour growth in combination with the antioxidant resveratrol. The work introduces a potentially new application for a broad range of micro- and nanoparticles to maximize receptor-mediated signalling and function in the presence of physical forces.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ncomms14179", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2438804", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4243616", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345462", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2699100", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis", 
        "pagination": "14179", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6cf9e099391c6182e4ca5cb86ce8b56cd5761808de4535e295033cfb698952dd"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28317839"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ncomms14179"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1084128789"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ncomms14179", 
          "https://app.dimensions.ai/details/publication/pub.1084128789"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T22:48", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000608.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/ncomms14179"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms14179'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms14179'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms14179'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms14179'


     

    This table displays all metadata directly associated to this object as RDF triples.

    361 TRIPLES      21 PREDICATES      103 URIs      33 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ncomms14179 schema:about N1017e4020ae448a28f9afa8b938e5277
    2 N25a661fb4605420daad9e5ca190ad28c
    3 N3ada12a749d649a6ac7f9a1a4345b1ed
    4 N6a9d7a12a6bd421794c74e6c744e2cbd
    5 N7dc88659a43c461b909bb3a7659e02cd
    6 N8e7ec88e965b45198f8db9b330d24272
    7 Nc191f640df1845ed8aca8e6d7ba5af09
    8 Nc3586c54eb074411a3a149f87e247f1e
    9 Nc36d8ecd317d4ee19ffe831ed556edaf
    10 Nc64f0df462b64898821386b986c75e4f
    11 Nd6a92d8d7e864193b959232f7e2c05b7
    12 Ne2636946dc20491f9edfca40bc52617d
    13 Nfa7e5ac7f7c845dcac280a32a5aa708c
    14 Nfea3d06baa7f4984b440560faf3eb45b
    15 anzsrc-for:11
    16 anzsrc-for:1107
    17 schema:author N65c27f04ae19467cbd6ba006f6c08a8f
    18 schema:citation sg:pub.10.1007/s12195-008-0022-x
    19 sg:pub.10.1023/a:1020031023947
    20 sg:pub.10.1038/nature02388
    21 sg:pub.10.1038/nature06254
    22 sg:pub.10.1038/nature10316
    23 sg:pub.10.1038/nmat3406
    24 sg:pub.10.1038/nmat3430
    25 sg:pub.10.1038/nnano.2007.387
    26 sg:pub.10.1038/nnano.2007.418
    27 sg:pub.10.1038/nrc2544
    28 sg:pub.10.1038/nrc3080
    29 sg:pub.10.1038/nrc3186
    30 sg:pub.10.1038/nrm2596
    31 sg:pub.10.1038/onc.2010.221
    32 sg:pub.10.1038/onc.2012.164
    33 sg:pub.10.1038/sj.cgt.7700792
    34 sg:pub.10.1038/srep09987
    35 sg:pub.10.1038/srep14872
    36 https://app.dimensions.ai/details/publication/pub.1074573419
    37 https://app.dimensions.ai/details/publication/pub.1074882356
    38 https://app.dimensions.ai/details/publication/pub.1076844165
    39 https://app.dimensions.ai/details/publication/pub.1077406153
    40 https://app.dimensions.ai/details/publication/pub.1078733618
    41 https://app.dimensions.ai/details/publication/pub.1079921416
    42 https://app.dimensions.ai/details/publication/pub.1083258120
    43 https://doi.org/10.1002/anie.200805179
    44 https://doi.org/10.1002/anie.201001149
    45 https://doi.org/10.1002/jbm.a.35445
    46 https://doi.org/10.1016/j.bcp.2005.05.018
    47 https://doi.org/10.1016/j.biomaterials.2011.01.054
    48 https://doi.org/10.1016/j.bpj.2014.04.001
    49 https://doi.org/10.1016/j.bpj.2014.12.023
    50 https://doi.org/10.1016/j.cell.2011.02.013
    51 https://doi.org/10.1016/j.ejca.2006.03.018
    52 https://doi.org/10.1016/j.ejpb.2008.09.011
    53 https://doi.org/10.1016/j.ijpharm.2005.10.010
    54 https://doi.org/10.1016/j.jconrel.2014.07.009
    55 https://doi.org/10.1016/s0006-3495(01)76090-0
    56 https://doi.org/10.1016/s0006-3495(04)74136-3
    57 https://doi.org/10.1016/s0092-8674(00)00112-4
    58 https://doi.org/10.1021/bc500427g
    59 https://doi.org/10.1021/mp800051m
    60 https://doi.org/10.1021/nl802689k
    61 https://doi.org/10.1039/b912438a
    62 https://doi.org/10.1042/bj20031253
    63 https://doi.org/10.1056/nejm198107163050305
    64 https://doi.org/10.1073/pnas.1103581108
    65 https://doi.org/10.1073/pnas.1316312111
    66 https://doi.org/10.1074/jbc.m110.183699
    67 https://doi.org/10.1088/1367-2630/15/1/015008
    68 https://doi.org/10.1093/emboj/cdf441
    69 https://doi.org/10.1093/jnci/57.5.1199
    70 https://doi.org/10.1126/science.1106587
    71 https://doi.org/10.1146/annurev.bioeng.9.060906.151850
    72 https://doi.org/10.1152/ajpcell.00285.2013
    73 https://doi.org/10.1158/1535-7163.mct-05-0262
    74 https://doi.org/10.1172/jci34359
    75 https://doi.org/10.1172/jci80420
    76 https://doi.org/10.1200/jco.2007.15.7198
    77 https://doi.org/10.1371/journal.pone.0015627
    78 https://doi.org/10.3389/fonc.2013.00001
    79 https://doi.org/10.3389/fonc.2013.00044
    80 schema:datePublished 2017-03-20
    81 schema:datePublishedReg 2017-03-20
    82 schema:description Physical forces affect tumour growth, progression and metastasis. Here, we develop polymeric mechanical amplifiers that exploit in vitro and in vivo physical forces to increase immune cytokine-mediated tumour cell apoptosis. Mechanical amplifiers, consisting of biodegradable polymeric particles tethered to the tumour cell surface via polyethylene glycol linkers, increase the apoptotic effect of an immune cytokine on tumour cells under fluid shear exposure by as much as 50% compared with treatment under static conditions. We show that targeted polymeric particles delivered to tumour cells in vivo amplify the apoptotic effect of a subsequent treatment of immune cytokine, reduce circulating tumour cells in blood and overall tumour cell burden by over 90% and reduce solid tumour growth in combination with the antioxidant resveratrol. The work introduces a potentially new application for a broad range of micro- and nanoparticles to maximize receptor-mediated signalling and function in the presence of physical forces.
    83 schema:genre research_article
    84 schema:inLanguage en
    85 schema:isAccessibleForFree true
    86 schema:isPartOf N43080bd6a1bb4551b7c11d9dbd563d02
    87 sg:journal.1043282
    88 schema:name Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
    89 schema:pagination 14179
    90 schema:productId N4e76aae421614da4b084c5a46dd7d89d
    91 N8d4a7305e40c409590a6a2bcdca7dd26
    92 N955496047e334692b8116d1d0afb3253
    93 Nd7d74d18c04240deb802f81bf93bd66d
    94 Nf768508543704d05aac918b19f08e267
    95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128789
    96 https://doi.org/10.1038/ncomms14179
    97 schema:sdDatePublished 2019-04-10T22:48
    98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    99 schema:sdPublisher Ndc0443e336854cb782350b12a5683964
    100 schema:url http://www.nature.com/articles/ncomms14179
    101 sgo:license sg:explorer/license/
    102 sgo:sdDataset articles
    103 rdf:type schema:ScholarlyArticle
    104 N1017e4020ae448a28f9afa8b938e5277 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Polyethylene Glycols
    106 rdf:type schema:DefinedTerm
    107 N25a661fb4605420daad9e5ca190ad28c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Humans
    109 rdf:type schema:DefinedTerm
    110 N3ada12a749d649a6ac7f9a1a4345b1ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Antineoplastic Agents
    112 rdf:type schema:DefinedTerm
    113 N43080bd6a1bb4551b7c11d9dbd563d02 schema:volumeNumber 8
    114 rdf:type schema:PublicationVolume
    115 N44a64b66f82249ae9c276895467990e8 rdf:first sg:person.01204756503.20
    116 rdf:rest N88613508f10f43cd885b92a647dbd3b6
    117 N4e76aae421614da4b084c5a46dd7d89d schema:name nlm_unique_id
    118 schema:value 101528555
    119 rdf:type schema:PropertyValue
    120 N65c27f04ae19467cbd6ba006f6c08a8f rdf:first sg:person.0637421331.51
    121 rdf:rest N85e4881b7fef4676b9a0d526f7f03cd7
    122 N6a9d7a12a6bd421794c74e6c744e2cbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Molecular Targeted Therapy
    124 rdf:type schema:DefinedTerm
    125 N7dc88659a43c461b909bb3a7659e02cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Polymers
    127 rdf:type schema:DefinedTerm
    128 N85e4881b7fef4676b9a0d526f7f03cd7 rdf:first sg:person.010405047175.56
    129 rdf:rest Nf140f9be907440fc966090668eeb3346
    130 N88613508f10f43cd885b92a647dbd3b6 rdf:first sg:person.01012772034.60
    131 rdf:rest Nfd1b90aebf0e449795898b1231ba64a3
    132 N8d4a7305e40c409590a6a2bcdca7dd26 schema:name readcube_id
    133 schema:value 6cf9e099391c6182e4ca5cb86ce8b56cd5761808de4535e295033cfb698952dd
    134 rdf:type schema:PropertyValue
    135 N8e7ec88e965b45198f8db9b330d24272 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Stress, Mechanical
    137 rdf:type schema:DefinedTerm
    138 N955496047e334692b8116d1d0afb3253 schema:name dimensions_id
    139 schema:value pub.1084128789
    140 rdf:type schema:PropertyValue
    141 Nc191f640df1845ed8aca8e6d7ba5af09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name TNF-Related Apoptosis-Inducing Ligand
    143 rdf:type schema:DefinedTerm
    144 Nc3586c54eb074411a3a149f87e247f1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Drug Synergism
    146 rdf:type schema:DefinedTerm
    147 Nc36d8ecd317d4ee19ffe831ed556edaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Drug Evaluation, Preclinical
    149 rdf:type schema:DefinedTerm
    150 Nc64f0df462b64898821386b986c75e4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Animals
    152 rdf:type schema:DefinedTerm
    153 Nd6a92d8d7e864193b959232f7e2c05b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Mice
    155 rdf:type schema:DefinedTerm
    156 Nd7d74d18c04240deb802f81bf93bd66d schema:name pubmed_id
    157 schema:value 28317839
    158 rdf:type schema:PropertyValue
    159 Ndc0443e336854cb782350b12a5683964 schema:name Springer Nature - SN SciGraph project
    160 rdf:type schema:Organization
    161 Ne2636946dc20491f9edfca40bc52617d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Nanoparticles
    163 rdf:type schema:DefinedTerm
    164 Nf140f9be907440fc966090668eeb3346 rdf:first sg:person.012244144163.00
    165 rdf:rest N44a64b66f82249ae9c276895467990e8
    166 Nf768508543704d05aac918b19f08e267 schema:name doi
    167 schema:value 10.1038/ncomms14179
    168 rdf:type schema:PropertyValue
    169 Nfa7e5ac7f7c845dcac280a32a5aa708c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Apoptosis
    171 rdf:type schema:DefinedTerm
    172 Nfd1b90aebf0e449795898b1231ba64a3 rdf:first sg:person.01117537642.02
    173 rdf:rest rdf:nil
    174 Nfea3d06baa7f4984b440560faf3eb45b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name HT29 Cells
    176 rdf:type schema:DefinedTerm
    177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    178 schema:name Medical and Health Sciences
    179 rdf:type schema:DefinedTerm
    180 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    181 schema:name Immunology
    182 rdf:type schema:DefinedTerm
    183 sg:grant.2345462 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms14179
    184 rdf:type schema:MonetaryGrant
    185 sg:grant.2438804 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms14179
    186 rdf:type schema:MonetaryGrant
    187 sg:grant.2699100 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms14179
    188 rdf:type schema:MonetaryGrant
    189 sg:grant.4243616 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms14179
    190 rdf:type schema:MonetaryGrant
    191 sg:journal.1043282 schema:issn 2041-1723
    192 schema:name Nature Communications
    193 rdf:type schema:Periodical
    194 sg:person.01012772034.60 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    195 schema:familyName Khan
    196 schema:givenName Omar F.
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012772034.60
    198 rdf:type schema:Person
    199 sg:person.010405047175.56 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    200 schema:familyName Webster
    201 schema:givenName Jamie
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010405047175.56
    203 rdf:type schema:Person
    204 sg:person.01117537642.02 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    205 schema:familyName Langer
    206 schema:givenName Robert
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117537642.02
    208 rdf:type schema:Person
    209 sg:person.01204756503.20 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    210 schema:familyName Guimarães
    211 schema:givenName Pedro P. G.
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204756503.20
    213 rdf:type schema:Person
    214 sg:person.012244144163.00 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    215 schema:familyName Chung
    216 schema:givenName Amanda
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012244144163.00
    218 rdf:type schema:Person
    219 sg:person.0637421331.51 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    220 schema:familyName Mitchell
    221 schema:givenName Michael J.
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637421331.51
    223 rdf:type schema:Person
    224 sg:pub.10.1007/s12195-008-0022-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042424752
    225 https://doi.org/10.1007/s12195-008-0022-x
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1023/a:1020031023947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046987267
    228 https://doi.org/10.1023/a:1020031023947
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nature02388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005911953
    231 https://doi.org/10.1038/nature02388
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nature06254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050531578
    234 https://doi.org/10.1038/nature06254
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nature10316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004484652
    237 https://doi.org/10.1038/nature10316
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nmat3406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035953857
    240 https://doi.org/10.1038/nmat3406
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nmat3430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017108578
    243 https://doi.org/10.1038/nmat3430
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nnano.2007.387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034703917
    246 https://doi.org/10.1038/nnano.2007.387
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nnano.2007.418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049627546
    249 https://doi.org/10.1038/nnano.2007.418
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nrc2544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017337522
    252 https://doi.org/10.1038/nrc2544
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nrc3080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034314308
    255 https://doi.org/10.1038/nrc3080
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/nrc3186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013800595
    258 https://doi.org/10.1038/nrc3186
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nrm2596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030218920
    261 https://doi.org/10.1038/nrm2596
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/onc.2010.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043860701
    264 https://doi.org/10.1038/onc.2010.221
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/onc.2012.164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006330641
    267 https://doi.org/10.1038/onc.2012.164
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/sj.cgt.7700792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044033045
    270 https://doi.org/10.1038/sj.cgt.7700792
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/srep09987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044835586
    273 https://doi.org/10.1038/srep09987
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/srep14872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030735815
    276 https://doi.org/10.1038/srep14872
    277 rdf:type schema:CreativeWork
    278 https://app.dimensions.ai/details/publication/pub.1074573419 schema:CreativeWork
    279 https://app.dimensions.ai/details/publication/pub.1074882356 schema:CreativeWork
    280 https://app.dimensions.ai/details/publication/pub.1076844165 schema:CreativeWork
    281 https://app.dimensions.ai/details/publication/pub.1077406153 schema:CreativeWork
    282 https://app.dimensions.ai/details/publication/pub.1078733618 schema:CreativeWork
    283 https://app.dimensions.ai/details/publication/pub.1079921416 schema:CreativeWork
    284 https://app.dimensions.ai/details/publication/pub.1083258120 schema:CreativeWork
    285 https://doi.org/10.1002/anie.200805179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040015698
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1002/anie.201001149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009679551
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1002/jbm.a.35445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030225057
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.bcp.2005.05.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048568319
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.biomaterials.2011.01.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020338251
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.bpj.2014.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030581600
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.bpj.2014.12.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000987319
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.ejca.2006.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005479285
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.ejpb.2008.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049562052
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/j.ijpharm.2005.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001767435
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/j.jconrel.2014.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026191653
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/s0006-3495(01)76090-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018303818
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/s0006-3495(04)74136-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017503368
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/s0092-8674(00)00112-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039444748
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1021/bc500427g schema:sameAs https://app.dimensions.ai/details/publication/pub.1033606320
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1021/mp800051m schema:sameAs https://app.dimensions.ai/details/publication/pub.1050269388
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1021/nl802689k schema:sameAs https://app.dimensions.ai/details/publication/pub.1056221573
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1039/b912438a schema:sameAs https://app.dimensions.ai/details/publication/pub.1038357785
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1042/bj20031253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009110644
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1056/nejm198107163050305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027347222
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1073/pnas.1103581108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008096838
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1073/pnas.1316312111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053170268
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1074/jbc.m110.183699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038492099
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1088/1367-2630/15/1/015008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059135919
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1093/emboj/cdf441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007465513
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1093/jnci/57.5.1199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074254624
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1126/science.1106587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045265288
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1146/annurev.bioeng.9.060906.151850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042643673
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1152/ajpcell.00285.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016226893
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1158/1535-7163.mct-05-0262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048492521
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1172/jci34359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043005792
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1172/jci80420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022292043
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1200/jco.2007.15.7198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037648394
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1371/journal.pone.0015627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025164198
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.3389/fonc.2013.00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029085281
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.3389/fonc.2013.00044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043236405
    358 rdf:type schema:CreativeWork
    359 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
    360 schema:name Department of Chemical Engineering, David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts 02139, USA
    361 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...