Centrality in the host–pathogen interactome is associated with pathogen fitness during infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-01-16

AUTHORS

Núria Crua Asensio, Elisabet Muñoz Giner, Natalia Sánchez de Groot, Marc Torrent Burgas

ABSTRACT

To perform their functions proteins must interact with each other, but how these interactions influence bacterial infection remains elusive. Here we demonstrate that connectivity in the host-pathogen interactome is directly related to pathogen fitness during infection. Using Y. pestis as a model organism, we show that the centrality-lethality rule holds for pathogen fitness during infection but only when the host-pathogen interactome is considered. Our results suggest that the importance of pathogen proteins during infection is directly related to their number of interactions with the host. We also show that pathogen proteins causing an extensive rewiring of the host interactome have a higher impact in pathogen fitness during infection. Hence, we conclude that hubs in the host-pathogen interactome should be explored as promising targets for antimicrobial drug design. More... »

PAGES

14092

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms14092

DOI

http://dx.doi.org/10.1038/ncomms14092

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013670764

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28090086


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