Innate and adaptive immune traits are differentially affected by genetic and environmental factors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-01-05

AUTHORS

Massimo Mangino, Mario Roederer, Margaret H Beddall, Frank O Nestle, Tim D Spector

ABSTRACT

The diversity and activity of leukocytes is controlled by genetic and environmental influences to maintain balanced immune responses. However, the relative contribution of environmental compared with genetic factors that affect variations in immune traits is unknown. Here we analyse 23,394 immune phenotypes in 497 adult female twins. 76% of these traits show a predominantly heritable influence, whereas 24% are mostly influenced by environment. These data highlight the importance of shared childhood environmental influences such as diet, infections or microbes in shaping immune homeostasis for monocytes, B1 cells, γδ T cells and NKT cells, whereas dendritic cells, B2 cells, CD4+ T and CD8+ T cells are more influenced by genetics. Although leukocyte subsets are influenced by genetics and environment, adaptive immune traits are more affected by genetics, whereas innate immune traits are more affected by environment. More... »

PAGES

13850

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms13850

DOI

http://dx.doi.org/10.1038/ncomms13850

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041708542

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28054551


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