Transcriptional bursting is intrinsically caused by interplay between RNA polymerases on DNA View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12-07

AUTHORS

Keisuke Fujita, Mitsuhiro Iwaki, Toshio Yanagida

ABSTRACT

Cell-to-cell variability plays a critical role in cellular responses and decision-making in a population, and transcriptional bursting has been broadly studied by experimental and theoretical approaches as the potential source of cell-to-cell variability. Although molecular mechanisms of transcriptional bursting have been proposed, there is little consensus. An unsolved key question is whether transcriptional bursting is intertwined with many transcriptional regulatory factors or is an intrinsic characteristic of RNA polymerase on DNA. Here we design an in vitro single-molecule measurement system to analyse the kinetics of transcriptional bursting. The results indicate that transcriptional bursting is caused by interplay between RNA polymerases on DNA. The kinetics of in vitro transcriptional bursting is quantitatively consistent with the gene-nonspecific kinetics previously observed in noisy gene expression in vivo. Our kinetic analysis based on a cellular automaton model confirms that arrest and rescue by trailing RNA polymerase intrinsically causes transcriptional bursting. More... »

PAGES

13788

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms13788

DOI

http://dx.doi.org/10.1038/ncomms13788

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049423274

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27924870


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