Heritability of the shape of subcortical brain structures in the general population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12-15

AUTHORS

Gennady V Roshchupkin, Boris A Gutman, Meike W Vernooij, Neda Jahanshad, Nicholas G Martin, Albert Hofman, Katie L McMahon, Sven J van der Lee, Cornelia M van Duijn, Greig I de Zubicaray, André G Uitterlinden, Margaret J Wright, Wiro J Niessen, Paul M Thompson, M Arfan Ikram, Hieab H H Adams

ABSTRACT

The volumes of subcortical brain structures are highly heritable, but genetic underpinnings of their shape remain relatively obscure. Here we determine the relative contribution of genetic factors to individual variation in the shape of seven bilateral subcortical structures: the nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen and thalamus. In 3,686 unrelated individuals aged between 45 and 98 years, brain magnetic resonance imaging and genotyping was performed. The maximal heritability of shape varies from 32.7 to 53.3% across the subcortical structures. Genetic contributions to shape extend beyond influences on intracranial volume and the gross volume of the respective structure. The regional variance in heritability was related to the reliability of the measurements, but could not be accounted for by technical factors only. These findings could be replicated in an independent sample of 1,040 twins. Differences in genetic contributions within a single region reveal the value of refined brain maps to appreciate the genetic complexity of brain structures. More... »

PAGES

13738

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms13738

DOI

http://dx.doi.org/10.1038/ncomms13738

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003462058

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27976715


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