Powerful decomposition of complex traits in a diploid model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11-02

AUTHORS

Johan Hallin, Kaspar Märtens, Alexander I Young, Martin Zackrisson, Francisco Salinas, Leopold Parts, Jonas Warringer, Gianni Liti

ABSTRACT

Explaining trait differences between individuals is a core and challenging aim of life sciences. Here, we introduce a powerful framework for complete decomposition of trait variation into its underlying genetic causes in diploid model organisms. We sequence and systematically pair the recombinant gametes of two intercrossed natural genomes into an array of diploid hybrids with fully assembled and phased genomes, termed Phased Outbred Lines (POLs). We demonstrate the capacity of this approach by partitioning fitness traits of 6,642 Saccharomyces cerevisiae POLs across many environments, achieving near complete trait heritability and precisely estimating additive (73%), dominance (10%), second (7%) and third (1.7%) order epistasis components. We map quantitative trait loci (QTLs) and find nonadditive QTLs to outnumber (3:1) additive loci, dominant contributions to heterosis to outnumber overdominant, and extensive pleiotropy. The POL framework offers the most complete decomposition of diploid traits to date and can be adapted to most model organisms. More... »

PAGES

13311

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms13311

DOI

http://dx.doi.org/10.1038/ncomms13311

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026797275

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27804950


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