EGFR oligomerization organizes kinase-active dimers into competent signalling platforms View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10-31

AUTHORS

Sarah R Needham, Selene K Roberts, Anton Arkhipov, Venkatesh P Mysore, Christopher J Tynan, Laura C Zanetti-Domingues, Eric T Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J Rolfe, David T Clarke, Martyn D Winn, Alireza Lajevardipour, Andrew H A Clayton, Linda J Pike, Michela Perani, Peter J Parker, Yibing Shan, David E Shaw, Marisa L Martin-Fernandez

ABSTRACT

Epidermal growth factor receptor (EGFR) signalling is activated by ligand-induced receptor dimerization. Notably, ligand binding also induces EGFR oligomerization, but the structures and functions of the oligomers are poorly understood. Here, we use fluorophore localization imaging with photobleaching to probe the structure of EGFR oligomers. We find that at physiological epidermal growth factor (EGF) concentrations, EGFR assembles into oligomers, as indicated by pairwise distances of receptor-bound fluorophore-conjugated EGF ligands. The pairwise ligand distances correspond well with the predictions of our structural model of the oligomers constructed from molecular dynamics simulations. The model suggests that oligomerization is mediated extracellularly by unoccupied ligand-binding sites and that oligomerization organizes kinase-active dimers in ways optimal for auto-phosphorylation in trans between neighbouring dimers. We argue that ligand-induced oligomerization is essential to the regulation of EGFR signalling. More... »

PAGES

13307

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms13307

DOI

http://dx.doi.org/10.1038/ncomms13307

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013280320

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27796308


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