Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10-26

AUTHORS

Jenna Scotcher, Oleksandra Prysyazhna, Andrii Boguslavskyi, Kornel Kistamas, Natasha Hadgraft, Eva D. Martin, Jenny Worthington, Olena Rudyk, Pedro Rodriguez Cutillas, Friederike Cuello, Michael J. Shattock, Michael S. Marber, Maria R. Conte, Adam Greenstein, David J. Greensmith, Luigi Venetucci, John F. Timms, Philip Eaton

ABSTRACT

The Frank–Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and oxidants are produced. Here we show that protein kinase G Iα (PKGIα) is oxidant-activated during stretch and this form of the kinase selectively phosphorylates cardiac phospholamban Ser16—a site important for diastolic relaxation. We find that hearts of Cys42Ser PKGIα knock-in (KI) mice, which are resistant to PKGIα oxidation, have diastolic dysfunction and a diminished ability to couple ventricular filling with cardiac output on a beat-to-beat basis. Intracellular calcium dynamics of ventricular myocytes isolated from KI hearts are altered in a manner consistent with impaired relaxation and contractile function. We conclude that oxidation of PKGIα during myocardial stretch is crucial for diastolic relaxation and fine-tunes the Frank–Starling response. More... »

PAGES

13187

References to SciGraph publications

Journal

TITLE

Nature Communications

ISSUE

1

VOLUME

7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms13187

DOI

http://dx.doi.org/10.1038/ncomms13187

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043451169

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27782102


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomechanical Phenomena", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiac Output", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic GMP-Dependent Protein Kinase Type I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diastole", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disulfides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Knock-In Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Ventricles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Contraction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocytes, Cardiac", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Culture Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidation-Reduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Primary Cell Culture", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Substrate Specificity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scotcher", 
        "givenName": "Jenna", 
        "id": "sg:person.0762155072.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762155072.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prysyazhna", 
        "givenName": "Oleksandra", 
        "id": "sg:person.01030463221.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030463221.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boguslavskyi", 
        "givenName": "Andrii", 
        "id": "sg:person.01040200017.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040200017.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cardiovascular Sciences, Manchester Academic Health Science Centre, Core Technology Facility, University of Manchester, 46 Grafton Street, M13 9NT, Manchester, UK", 
          "id": "http://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "Institute of Cardiovascular Sciences, Manchester Academic Health Science Centre, Core Technology Facility, University of Manchester, 46 Grafton Street, M13 9NT, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kistamas", 
        "givenName": "Kornel", 
        "id": "sg:person.01076341306.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076341306.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biomedical Research Centre, University of Salford, Peel Building, M5 4WT, Salford Crescent, UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Biomedical Research Centre, University of Salford, Peel Building, M5 4WT, Salford Crescent, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hadgraft", 
        "givenName": "Natasha", 
        "id": "sg:person.010234021775.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010234021775.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martin", 
        "givenName": "Eva D.", 
        "id": "sg:person.01263436726.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263436726.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Women\u2019s Health, University College London, Gower Street, WC1E 6BT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Institute for Women\u2019s Health, University College London, Gower Street, WC1E 6BT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Worthington", 
        "givenName": "Jenny", 
        "id": "sg:person.011626762775.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011626762775.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rudyk", 
        "givenName": "Olena", 
        "id": "sg:person.01076576421.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076576421.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.4868.2", 
          "name": [
            "Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodriguez Cutillas", 
        "givenName": "Pedro", 
        "id": "sg:person.013221723775.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013221723775.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Centre, University Medical Center Hamburg-Eppendorf, Hamburg, DZHK (German Centre for Cardiovascular Research), Partner site Hamburg/Kiel/L\u00fcbeck, 20246, Hamburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Centre, University Medical Center Hamburg-Eppendorf, Hamburg, DZHK (German Centre for Cardiovascular Research), Partner site Hamburg/Kiel/L\u00fcbeck, 20246, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cuello", 
        "givenName": "Friederike", 
        "id": "sg:person.01020107713.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020107713.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shattock", 
        "givenName": "Michael J.", 
        "id": "sg:person.01327556720.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327556720.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marber", 
        "givenName": "Michael S.", 
        "id": "sg:person.014114567037.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014114567037.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Randall Division of Cell and Molecular Biophysics, King\u2019s College London, New Hunt\u2019s House, Guy\u2019s Campus, SE1 1UL, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Randall Division of Cell and Molecular Biophysics, King\u2019s College London, New Hunt\u2019s House, Guy\u2019s Campus, SE1 1UL, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Conte", 
        "givenName": "Maria R.", 
        "id": "sg:person.0741777347.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741777347.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cardiovascular Sciences, Manchester Academic Health Science Centre, Core Technology Facility, University of Manchester, 46 Grafton Street, M13 9NT, Manchester, UK", 
          "id": "http://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "Institute of Cardiovascular Sciences, Manchester Academic Health Science Centre, Core Technology Facility, University of Manchester, 46 Grafton Street, M13 9NT, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Greenstein", 
        "givenName": "Adam", 
        "id": "sg:person.0626157642.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626157642.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biomedical Research Centre, University of Salford, Peel Building, M5 4WT, Salford Crescent, UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Biomedical Research Centre, University of Salford, Peel Building, M5 4WT, Salford Crescent, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Greensmith", 
        "givenName": "David J.", 
        "id": "sg:person.01304753631.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304753631.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cardiovascular Sciences, Manchester Academic Health Science Centre, Core Technology Facility, University of Manchester, 46 Grafton Street, M13 9NT, Manchester, UK", 
          "id": "http://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "Institute of Cardiovascular Sciences, Manchester Academic Health Science Centre, Core Technology Facility, University of Manchester, 46 Grafton Street, M13 9NT, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Venetucci", 
        "givenName": "Luigi", 
        "id": "sg:person.01365167200.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365167200.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Women\u2019s Health, University College London, Gower Street, WC1E 6BT, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Institute for Women\u2019s Health, University College London, Gower Street, WC1E 6BT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Timms", 
        "givenName": "John F.", 
        "id": "sg:person.01256564545.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256564545.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.425213.3", 
          "name": [
            "Cardiovascular Division, King\u2019s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas\u2019 Hospital, SE1 7EH, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eaton", 
        "givenName": "Philip", 
        "id": "sg:person.01144711621.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144711621.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm.2603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032744556", 
          "https://doi.org/10.1038/nm.2603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth1048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053570721", 
          "https://doi.org/10.1038/nmeth1048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/415198a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023748395", 
          "https://doi.org/10.1038/415198a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003043359", 
          "https://doi.org/10.1038/nrm1151"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-10-26", 
    "datePublishedReg": "2016-10-26", 
    "description": "The Frank\u2013Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and oxidants are produced. Here we show that protein kinase G I\u03b1 (PKGI\u03b1) is oxidant-activated during stretch and this form of the kinase selectively phosphorylates cardiac phospholamban Ser16\u2014a site important for diastolic relaxation. We find that hearts of Cys42Ser PKGI\u03b1 knock-in (KI) mice, which are resistant to PKGI\u03b1 oxidation, have diastolic dysfunction and a diminished ability to couple ventricular filling with cardiac output on a beat-to-beat basis. Intracellular calcium dynamics of ventricular myocytes isolated from KI hearts are altered in a manner consistent with impaired relaxation and contractile function. We conclude that oxidation of PKGI\u03b1 during myocardial stretch is crucial for diastolic relaxation and fine-tunes the Frank\u2013Starling response.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ncomms13187", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5138622", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2753408", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5142355", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5135425", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6798564", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5135945", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5138948", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5138151", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5140194", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "diastolic relaxation", 
      "protein kinase G I\u03b1", 
      "cardiac diastolic relaxation", 
      "Frank-Starling response", 
      "Frank-Starling mechanism", 
      "amount of blood", 
      "diastolic dysfunction", 
      "impaired relaxation", 
      "cardiac output", 
      "contractile function", 
      "arterial circulation", 
      "myocardial stretch", 
      "intracellular calcium dynamics", 
      "ventricular myocytes", 
      "KI hearts", 
      "beat basis", 
      "diminished ability", 
      "calcium dynamics", 
      "heart", 
      "blood", 
      "PKGI\u03b1", 
      "dysfunction", 
      "myocardium", 
      "mice", 
      "diastole", 
      "myocytes", 
      "response", 
      "vein", 
      "beats", 
      "Ser16", 
      "circulation", 
      "kinase", 
      "stretch", 
      "relaxation", 
      "manner", 
      "mechanism", 
      "function", 
      "I\u03b1", 
      "ability", 
      "amount", 
      "sites", 
      "basis", 
      "form", 
      "output", 
      "Frank", 
      "oxidants", 
      "oxidation", 
      "disulfide", 
      "dynamics"
    ], 
    "name": "Disulfide-activated protein kinase G I\u03b1 regulates cardiac diastolic relaxation and fine-tunes the Frank\u2013Starling response", 
    "pagination": "13187", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043451169"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms13187"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27782102"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms13187", 
      "https://app.dimensions.ai/details/publication/pub.1043451169"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_702.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ncomms13187"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms13187'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms13187'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms13187'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms13187'


 

This table displays all metadata directly associated to this object as RDF triples.

381 TRIPLES      22 PREDICATES      104 URIs      92 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms13187 schema:about N0124bdbe6a50429fa2d39ab494192ba6
2 N01e0446d446e4b3081b0feffb1f09934
3 N0315d7de82194118a710dd94600b06d7
4 N0c6b84f91abe4293958a2337d7c723e7
5 N13ff8f46f493441697567ca2d7cbcc86
6 N1c27ff918e7d4480b90b76b4e425c155
7 N1e995109c3d644bf8114546dbf6a8c94
8 N3ee944f314164048ab20ac5230998fb3
9 N4406505d1682429b8c353c1986e0b2bd
10 N576f065681754422b9fcb399a30857e8
11 N5dfa2bb4deb04d2eb473c2c54beb0341
12 N6c76833170f84337a17e4d228a629282
13 N70ec80ee860f416a80e6bd02569bf70d
14 N734e49cdb2d8472ca2f18265bb81c882
15 N947020d5fe754df2a1325a1fe5eb1b2f
16 Na45928faa4ba4b26a8ff97a1c79ee9db
17 Nb0b14c3df29a40be983e74adb8dfd6b0
18 Nb7ebf09404474b488bc3c697245b64c5
19 Nbcafa305041744efbd1fba906de0d974
20 Nc5922aea629d41d49e2692acd27852e1
21 Nc5c098e115f841939af62c6f974eea23
22 Nc80e39c32ea6416cad3475a82d1525cb
23 Ncec6ec7e789048a38383b7f2131a1f8d
24 Ne8254fc7a574494a9d57540b6e059a89
25 Nef938df09f5c458f8127b2cab2a98ef9
26 anzsrc-for:11
27 anzsrc-for:1102
28 schema:author N9757bfe4c6bc4caeaaf057f117a3495f
29 schema:citation sg:pub.10.1038/415198a
30 sg:pub.10.1038/nm.2603
31 sg:pub.10.1038/nmeth1048
32 sg:pub.10.1038/nrm1151
33 schema:datePublished 2016-10-26
34 schema:datePublishedReg 2016-10-26
35 schema:description The Frank–Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and oxidants are produced. Here we show that protein kinase G Iα (PKGIα) is oxidant-activated during stretch and this form of the kinase selectively phosphorylates cardiac phospholamban Ser16—a site important for diastolic relaxation. We find that hearts of Cys42Ser PKGIα knock-in (KI) mice, which are resistant to PKGIα oxidation, have diastolic dysfunction and a diminished ability to couple ventricular filling with cardiac output on a beat-to-beat basis. Intracellular calcium dynamics of ventricular myocytes isolated from KI hearts are altered in a manner consistent with impaired relaxation and contractile function. We conclude that oxidation of PKGIα during myocardial stretch is crucial for diastolic relaxation and fine-tunes the Frank–Starling response.
36 schema:genre article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N0a2c630c7bd749449d41b7fc8d46584a
40 N0c1cb08de8d14436ada1e304da322974
41 sg:journal.1043282
42 schema:keywords Frank
43 Frank-Starling mechanism
44 Frank-Starling response
45
46 KI hearts
47 PKGIα
48 Ser16
49 ability
50 amount
51 amount of blood
52 arterial circulation
53 basis
54 beat basis
55 beats
56 blood
57 calcium dynamics
58 cardiac diastolic relaxation
59 cardiac output
60 circulation
61 contractile function
62 diastole
63 diastolic dysfunction
64 diastolic relaxation
65 diminished ability
66 disulfide
67 dynamics
68 dysfunction
69 form
70 function
71 heart
72 impaired relaxation
73 intracellular calcium dynamics
74 kinase
75 manner
76 mechanism
77 mice
78 myocardial stretch
79 myocardium
80 myocytes
81 output
82 oxidants
83 oxidation
84 protein kinase G Iα
85 relaxation
86 response
87 sites
88 stretch
89 vein
90 ventricular myocytes
91 schema:name Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response
92 schema:pagination 13187
93 schema:productId N16f6eca1b4c44705b2309b76323e79ad
94 N1f9972c65d5a465da5c780c5712657a2
95 Ne329fe6218df49b0b79a6da4cb831fac
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043451169
97 https://doi.org/10.1038/ncomms13187
98 schema:sdDatePublished 2022-06-01T22:16
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher N491d74e3a8a347089dcbcfa0c7c3de4b
101 schema:url https://doi.org/10.1038/ncomms13187
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N0124bdbe6a50429fa2d39ab494192ba6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Cardiac Output
107 rdf:type schema:DefinedTerm
108 N01e0446d446e4b3081b0feffb1f09934 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Gene Expression Profiling
110 rdf:type schema:DefinedTerm
111 N0315d7de82194118a710dd94600b06d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Oxidative Stress
113 rdf:type schema:DefinedTerm
114 N07de5db8a44f4bceb99c8ad636a37f1c rdf:first sg:person.014114567037.40
115 rdf:rest N501b2ead1e2e41a3ad737bffaea2f472
116 N0a2c630c7bd749449d41b7fc8d46584a schema:issueNumber 1
117 rdf:type schema:PublicationIssue
118 N0c1cb08de8d14436ada1e304da322974 schema:volumeNumber 7
119 rdf:type schema:PublicationVolume
120 N0c6b84f91abe4293958a2337d7c723e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Animals
122 rdf:type schema:DefinedTerm
123 N13ff8f46f493441697567ca2d7cbcc86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Disulfides
125 rdf:type schema:DefinedTerm
126 N16f6eca1b4c44705b2309b76323e79ad schema:name pubmed_id
127 schema:value 27782102
128 rdf:type schema:PropertyValue
129 N1c27ff918e7d4480b90b76b4e425c155 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Calcium
131 rdf:type schema:DefinedTerm
132 N1e995109c3d644bf8114546dbf6a8c94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Heart Ventricles
134 rdf:type schema:DefinedTerm
135 N1f9972c65d5a465da5c780c5712657a2 schema:name dimensions_id
136 schema:value pub.1043451169
137 rdf:type schema:PropertyValue
138 N23be1a7b349f440ba356b4659fa36683 rdf:first sg:person.01327556720.34
139 rdf:rest N07de5db8a44f4bceb99c8ad636a37f1c
140 N35c0f15a6d6146c2a527dfeca79502f6 rdf:first sg:person.01020107713.88
141 rdf:rest N23be1a7b349f440ba356b4659fa36683
142 N3ee944f314164048ab20ac5230998fb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Mice
144 rdf:type schema:DefinedTerm
145 N4406505d1682429b8c353c1986e0b2bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Oxidation-Reduction
147 rdf:type schema:DefinedTerm
148 N491d74e3a8a347089dcbcfa0c7c3de4b schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 N494c6e05fa0146aba70c441a5453d5c8 rdf:first sg:person.01263436726.56
151 rdf:rest Ndac722db5e5649259728c5a36b45be9b
152 N501b2ead1e2e41a3ad737bffaea2f472 rdf:first sg:person.0741777347.89
153 rdf:rest Nf7a3cf77f1ec4b59bc2e2c90f6e67ec1
154 N54b0bbe0b6484cd48eff22a1b3e095c7 rdf:first sg:person.010234021775.25
155 rdf:rest N494c6e05fa0146aba70c441a5453d5c8
156 N576f065681754422b9fcb399a30857e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Phosphorylation
158 rdf:type schema:DefinedTerm
159 N5abe6fd7aec94c63aee4fb256ca0babb rdf:first sg:person.01304753631.72
160 rdf:rest N97c21bb0a78d4f8d9d8d135cec9190c7
161 N5dfa2bb4deb04d2eb473c2c54beb0341 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Diastole
163 rdf:type schema:DefinedTerm
164 N6b1b2bd5f1064dcdb340a602dc0c6186 rdf:first sg:person.013221723775.64
165 rdf:rest N35c0f15a6d6146c2a527dfeca79502f6
166 N6c76833170f84337a17e4d228a629282 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Male
168 rdf:type schema:DefinedTerm
169 N70ec80ee860f416a80e6bd02569bf70d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Primary Cell Culture
171 rdf:type schema:DefinedTerm
172 N734e49cdb2d8472ca2f18265bb81c882 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Serine
174 rdf:type schema:DefinedTerm
175 N79d822b7a18e4557a55cc075fba282c0 rdf:first sg:person.01076341306.25
176 rdf:rest N54b0bbe0b6484cd48eff22a1b3e095c7
177 N83e95f33f3a34773a983e28a98265f9b rdf:first sg:person.01256564545.61
178 rdf:rest Nf7fa87cf562f4bf591ef198a4ba5a7da
179 N8b66a51f967b485c9f7ddcfcd844512d rdf:first sg:person.01040200017.48
180 rdf:rest N79d822b7a18e4557a55cc075fba282c0
181 N947020d5fe754df2a1325a1fe5eb1b2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Cyclic GMP-Dependent Protein Kinase Type I
183 rdf:type schema:DefinedTerm
184 N9757bfe4c6bc4caeaaf057f117a3495f rdf:first sg:person.0762155072.38
185 rdf:rest Nad1e2406294a4723a445249bd082d4b3
186 N97c21bb0a78d4f8d9d8d135cec9190c7 rdf:first sg:person.01365167200.34
187 rdf:rest N83e95f33f3a34773a983e28a98265f9b
188 Na45928faa4ba4b26a8ff97a1c79ee9db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Organ Culture Techniques
190 rdf:type schema:DefinedTerm
191 Nad1e2406294a4723a445249bd082d4b3 rdf:first sg:person.01030463221.50
192 rdf:rest N8b66a51f967b485c9f7ddcfcd844512d
193 Nb0b14c3df29a40be983e74adb8dfd6b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Myocardial Contraction
195 rdf:type schema:DefinedTerm
196 Nb7ebf09404474b488bc3c697245b64c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Gene Expression Regulation
198 rdf:type schema:DefinedTerm
199 Nbcafa305041744efbd1fba906de0d974 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Mice, Inbred C57BL
201 rdf:type schema:DefinedTerm
202 Nc5922aea629d41d49e2692acd27852e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Myocardium
204 rdf:type schema:DefinedTerm
205 Nc5c098e115f841939af62c6f974eea23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Myocytes, Cardiac
207 rdf:type schema:DefinedTerm
208 Nc80e39c32ea6416cad3475a82d1525cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Biomechanical Phenomena
210 rdf:type schema:DefinedTerm
211 Ncec6ec7e789048a38383b7f2131a1f8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Substrate Specificity
213 rdf:type schema:DefinedTerm
214 Ndac722db5e5649259728c5a36b45be9b rdf:first sg:person.011626762775.72
215 rdf:rest Nde879d061d8b4e4197ac6766a864be72
216 Nde879d061d8b4e4197ac6766a864be72 rdf:first sg:person.01076576421.28
217 rdf:rest N6b1b2bd5f1064dcdb340a602dc0c6186
218 Ne329fe6218df49b0b79a6da4cb831fac schema:name doi
219 schema:value 10.1038/ncomms13187
220 rdf:type schema:PropertyValue
221 Ne8254fc7a574494a9d57540b6e059a89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Calcium-Binding Proteins
223 rdf:type schema:DefinedTerm
224 Nef938df09f5c458f8127b2cab2a98ef9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Gene Knock-In Techniques
226 rdf:type schema:DefinedTerm
227 Nf7a3cf77f1ec4b59bc2e2c90f6e67ec1 rdf:first sg:person.0626157642.69
228 rdf:rest N5abe6fd7aec94c63aee4fb256ca0babb
229 Nf7fa87cf562f4bf591ef198a4ba5a7da rdf:first sg:person.01144711621.39
230 rdf:rest rdf:nil
231 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
232 schema:name Medical and Health Sciences
233 rdf:type schema:DefinedTerm
234 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
235 schema:name Cardiorespiratory Medicine and Haematology
236 rdf:type schema:DefinedTerm
237 sg:grant.2753408 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms13187
238 rdf:type schema:MonetaryGrant
239 sg:grant.5135425 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms13187
240 rdf:type schema:MonetaryGrant
241 sg:grant.5135945 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms13187
242 rdf:type schema:MonetaryGrant
243 sg:grant.5138151 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms13187
244 rdf:type schema:MonetaryGrant
245 sg:grant.5138622 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms13187
246 rdf:type schema:MonetaryGrant
247 sg:grant.5138948 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms13187
248 rdf:type schema:MonetaryGrant
249 sg:grant.5140194 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms13187
250 rdf:type schema:MonetaryGrant
251 sg:grant.5142355 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms13187
252 rdf:type schema:MonetaryGrant
253 sg:grant.6798564 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms13187
254 rdf:type schema:MonetaryGrant
255 sg:journal.1043282 schema:issn 2041-1723
256 schema:name Nature Communications
257 schema:publisher Springer Nature
258 rdf:type schema:Periodical
259 sg:person.01020107713.88 schema:affiliation grid-institutes:grid.13648.38
260 schema:familyName Cuello
261 schema:givenName Friederike
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020107713.88
263 rdf:type schema:Person
264 sg:person.010234021775.25 schema:affiliation grid-institutes:None
265 schema:familyName Hadgraft
266 schema:givenName Natasha
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010234021775.25
268 rdf:type schema:Person
269 sg:person.01030463221.50 schema:affiliation grid-institutes:grid.425213.3
270 schema:familyName Prysyazhna
271 schema:givenName Oleksandra
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030463221.50
273 rdf:type schema:Person
274 sg:person.01040200017.48 schema:affiliation grid-institutes:grid.425213.3
275 schema:familyName Boguslavskyi
276 schema:givenName Andrii
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040200017.48
278 rdf:type schema:Person
279 sg:person.01076341306.25 schema:affiliation grid-institutes:grid.5379.8
280 schema:familyName Kistamas
281 schema:givenName Kornel
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076341306.25
283 rdf:type schema:Person
284 sg:person.01076576421.28 schema:affiliation grid-institutes:grid.425213.3
285 schema:familyName Rudyk
286 schema:givenName Olena
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076576421.28
288 rdf:type schema:Person
289 sg:person.01144711621.39 schema:affiliation grid-institutes:grid.425213.3
290 schema:familyName Eaton
291 schema:givenName Philip
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144711621.39
293 rdf:type schema:Person
294 sg:person.011626762775.72 schema:affiliation grid-institutes:grid.83440.3b
295 schema:familyName Worthington
296 schema:givenName Jenny
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011626762775.72
298 rdf:type schema:Person
299 sg:person.01256564545.61 schema:affiliation grid-institutes:grid.83440.3b
300 schema:familyName Timms
301 schema:givenName John F.
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256564545.61
303 rdf:type schema:Person
304 sg:person.01263436726.56 schema:affiliation grid-institutes:grid.425213.3
305 schema:familyName Martin
306 schema:givenName Eva D.
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263436726.56
308 rdf:type schema:Person
309 sg:person.01304753631.72 schema:affiliation grid-institutes:None
310 schema:familyName Greensmith
311 schema:givenName David J.
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304753631.72
313 rdf:type schema:Person
314 sg:person.013221723775.64 schema:affiliation grid-institutes:grid.4868.2
315 schema:familyName Rodriguez Cutillas
316 schema:givenName Pedro
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013221723775.64
318 rdf:type schema:Person
319 sg:person.01327556720.34 schema:affiliation grid-institutes:grid.425213.3
320 schema:familyName Shattock
321 schema:givenName Michael J.
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327556720.34
323 rdf:type schema:Person
324 sg:person.01365167200.34 schema:affiliation grid-institutes:grid.5379.8
325 schema:familyName Venetucci
326 schema:givenName Luigi
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365167200.34
328 rdf:type schema:Person
329 sg:person.014114567037.40 schema:affiliation grid-institutes:grid.425213.3
330 schema:familyName Marber
331 schema:givenName Michael S.
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014114567037.40
333 rdf:type schema:Person
334 sg:person.0626157642.69 schema:affiliation grid-institutes:grid.5379.8
335 schema:familyName Greenstein
336 schema:givenName Adam
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626157642.69
338 rdf:type schema:Person
339 sg:person.0741777347.89 schema:affiliation grid-institutes:grid.13097.3c
340 schema:familyName Conte
341 schema:givenName Maria R.
342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741777347.89
343 rdf:type schema:Person
344 sg:person.0762155072.38 schema:affiliation grid-institutes:grid.425213.3
345 schema:familyName Scotcher
346 schema:givenName Jenna
347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762155072.38
348 rdf:type schema:Person
349 sg:pub.10.1038/415198a schema:sameAs https://app.dimensions.ai/details/publication/pub.1023748395
350 https://doi.org/10.1038/415198a
351 rdf:type schema:CreativeWork
352 sg:pub.10.1038/nm.2603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032744556
353 https://doi.org/10.1038/nm.2603
354 rdf:type schema:CreativeWork
355 sg:pub.10.1038/nmeth1048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053570721
356 https://doi.org/10.1038/nmeth1048
357 rdf:type schema:CreativeWork
358 sg:pub.10.1038/nrm1151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003043359
359 https://doi.org/10.1038/nrm1151
360 rdf:type schema:CreativeWork
361 grid-institutes:None schema:alternateName Biomedical Research Centre, University of Salford, Peel Building, M5 4WT, Salford Crescent, UK
362 schema:name Biomedical Research Centre, University of Salford, Peel Building, M5 4WT, Salford Crescent, UK
363 rdf:type schema:Organization
364 grid-institutes:grid.13097.3c schema:alternateName Randall Division of Cell and Molecular Biophysics, King’s College London, New Hunt’s House, Guy’s Campus, SE1 1UL, London, UK
365 schema:name Randall Division of Cell and Molecular Biophysics, King’s College London, New Hunt’s House, Guy’s Campus, SE1 1UL, London, UK
366 rdf:type schema:Organization
367 grid-institutes:grid.13648.38 schema:alternateName Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Centre, University Medical Center Hamburg-Eppendorf, Hamburg, DZHK (German Centre for Cardiovascular Research), Partner site Hamburg/Kiel/Lübeck, 20246, Hamburg, Germany
368 schema:name Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Centre, University Medical Center Hamburg-Eppendorf, Hamburg, DZHK (German Centre for Cardiovascular Research), Partner site Hamburg/Kiel/Lübeck, 20246, Hamburg, Germany
369 rdf:type schema:Organization
370 grid-institutes:grid.425213.3 schema:alternateName Cardiovascular Division, King’s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas’ Hospital, SE1 7EH, London, UK
371 schema:name Cardiovascular Division, King’s College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas’ Hospital, SE1 7EH, London, UK
372 rdf:type schema:Organization
373 grid-institutes:grid.4868.2 schema:alternateName Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, London, UK
374 schema:name Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, London, UK
375 rdf:type schema:Organization
376 grid-institutes:grid.5379.8 schema:alternateName Institute of Cardiovascular Sciences, Manchester Academic Health Science Centre, Core Technology Facility, University of Manchester, 46 Grafton Street, M13 9NT, Manchester, UK
377 schema:name Institute of Cardiovascular Sciences, Manchester Academic Health Science Centre, Core Technology Facility, University of Manchester, 46 Grafton Street, M13 9NT, Manchester, UK
378 rdf:type schema:Organization
379 grid-institutes:grid.83440.3b schema:alternateName Institute for Women’s Health, University College London, Gower Street, WC1E 6BT, London, UK
380 schema:name Institute for Women’s Health, University College London, Gower Street, WC1E 6BT, London, UK
381 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...