Enantioselective desymmetrization of cyclohexadienones via an intramolecular Rauhut–Currier reaction of allenoates View Full Text


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Article Info

DATE

2016-10-04

AUTHORS

Weijun Yao, Xiaowei Dou, Shan Wen, Ji’en Wu, Jagadese J. Vittal, Yixin Lu

ABSTRACT

The Rauhut–Currier (RC) reaction represents an efficient method for the construction of carbon–carbon bond in organic synthesis. However, the RC reactions involving allenoate substrates are very rare, and in particular, asymmetric intramolecular RC reaction of allenoates is yet to be discovered. Here, we show that the intramolecular RC reaction proceeds smoothly in the presence of 1 mol% β-ICD, and bicyclic lactones are obtained in high yields and with excellent enantiomeric excesses. With the employment of γ-substituted allenoates as racemic precursors, a novel dynamic kinetic resolution of allenes via RC reaction is observed, which allows for facile synthesis of highly enantiomerically enriched allenes. More... »

PAGES

13024

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms13024

DOI

http://dx.doi.org/10.1038/ncomms13024

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050225336

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27698487


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