PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09-14

AUTHORS

Coralie Drelon, Annabel Berthon, Isabelle Sahut-Barnola, Mickaël Mathieu, Typhanie Dumontet, Stéphanie Rodriguez, Marie Batisse-Lignier, Houda Tabbal, Igor Tauveron, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Celso E Gomez-Sanchez, Seppo Vainio, Jingdong Shan, Sonia Sacco, Andreas Schedl, Constantine A Stratakis, Antoine Martinez, Pierre Val

ABSTRACT

Adrenal cortex physiology relies on functional zonation, essential for production of aldosterone by outer zona glomerulosa (ZG) and glucocorticoids by inner zona fasciculata (ZF). The cortex undergoes constant cell renewal, involving recruitment of subcapsular progenitors to ZG fate and subsequent lineage conversion to ZF identity. Here we show that WNT4 is an important driver of WNT pathway activation and subsequent ZG differentiation and demonstrate that PKA activation prevents ZG differentiation through WNT4 repression and WNT pathway inhibition. This suggests that PKA activation in ZF is a key driver of WNT inhibition and lineage conversion. Furthermore, we provide evidence that constitutive PKA activation inhibits, whereas partial inactivation of PKA catalytic activity stimulates β-catenin-induced tumorigenesis. Together, both lower PKA activity and higher WNT pathway activity lead to poorer prognosis in adrenocortical carcinoma (ACC) patients. These observations suggest that PKA acts as a tumour suppressor in the adrenal cortex, through repression of WNT signalling. More... »

PAGES

12751

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms12751

DOI

http://dx.doi.org/10.1038/ncomms12751

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035458600

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27624192


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenal Gland Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP-Dependent Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Signaling Pathway", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zona Fasciculata", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zona Glomerulosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drelon", 
        "givenName": "Coralie", 
        "id": "sg:person.01062372067.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062372067.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Child Health and Human Development", 
          "id": "https://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France.", 
            "Developmental Endocrine Oncology and Genetics, Section on Genetics and Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892-1103, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berthon", 
        "givenName": "Annabel", 
        "id": "sg:person.01130505267.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130505267.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sahut-Barnola", 
        "givenName": "Isabelle", 
        "id": "sg:person.01324375171.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324375171.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mathieu", 
        "givenName": "Micka\u00ebl", 
        "id": "sg:person.01076077641.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076077641.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dumontet", 
        "givenName": "Typhanie", 
        "id": "sg:person.01206077604.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206077604.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodriguez", 
        "givenName": "St\u00e9phanie", 
        "id": "sg:person.0771144604.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771144604.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Clermont-Ferrand", 
          "id": "https://www.grid.ac/institutes/grid.411163.0", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France.", 
            "Centre Hospitalier Universitaire, Service d'Endocrinologie, Facult\u00e9 de M\u00e9decine, F-63000 Clermont-Ferrand, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Batisse-Lignier", 
        "givenName": "Marie", 
        "id": "sg:person.0703671367.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703671367.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tabbal", 
        "givenName": "Houda", 
        "id": "sg:person.016137532115.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016137532115.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Clermont-Ferrand", 
          "id": "https://www.grid.ac/institutes/grid.411163.0", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France.", 
            "Centre Hospitalier Universitaire, Service d'Endocrinologie, Facult\u00e9 de M\u00e9decine, F-63000 Clermont-Ferrand, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tauveron", 
        "givenName": "Igor", 
        "id": "sg:person.0663662016.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663662016.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lefran\u00e7ois-Martinez", 
        "givenName": "Anne-Marie", 
        "id": "sg:person.01107706210.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107706210.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pointud", 
        "givenName": "Jean-Christophe", 
        "id": "sg:person.0615170555.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615170555.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Mississippi Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410721.1", 
          "name": [
            "Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center, Jackson, Mississippi 39216, USA.", 
            "Department of Medicine-Endocrinology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gomez-Sanchez", 
        "givenName": "Celso E", 
        "id": "sg:person.015105677677.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015105677677.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oulu", 
          "id": "https://www.grid.ac/institutes/grid.10858.34", 
          "name": [
            "Biocenter Oulu, Laboratory of Developmental Biology, InfoTech Oulu, Center for cell Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90220 Oulu, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vainio", 
        "givenName": "Seppo", 
        "id": "sg:person.01104210067.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104210067.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oulu", 
          "id": "https://www.grid.ac/institutes/grid.10858.34", 
          "name": [
            "Biocenter Oulu, Laboratory of Developmental Biology, InfoTech Oulu, Center for cell Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90220 Oulu, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shan", 
        "givenName": "Jingdong", 
        "id": "sg:person.01276420514.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276420514.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biology Valrose", 
          "id": "https://www.grid.ac/institutes/grid.461605.0", 
          "name": [
            "Inserm UMR1091, CNRS UMR 7277, Institute of Biology Valrose, F-06108 Nice, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sacco", 
        "givenName": "Sonia", 
        "id": "sg:person.0674331441.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674331441.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biology Valrose", 
          "id": "https://www.grid.ac/institutes/grid.461605.0", 
          "name": [
            "Inserm UMR1091, CNRS UMR 7277, Institute of Biology Valrose, F-06108 Nice, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schedl", 
        "givenName": "Andreas", 
        "id": "sg:person.01104050527.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104050527.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Child Health and Human Development", 
          "id": "https://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Developmental Endocrine Oncology and Genetics, Section on Genetics and Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892-1103, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stratakis", 
        "givenName": "Constantine A", 
        "id": "sg:person.011151216517.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011151216517.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martinez", 
        "givenName": "Antoine", 
        "id": "sg:person.01371557114.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371557114.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "CNRS, UMR 6293, GReD, Inserm U1103, Clermont Universit\u00e9, F-63171 Aubi\u00e8re Cedex, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Val", 
        "givenName": "Pierre", 
        "id": "sg:person.01107250557.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107250557.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng1330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004116928", 
          "https://doi.org/10.1038/ng1330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004116928", 
          "https://doi.org/10.1038/ng1330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvg.20335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006785349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb3164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006924028", 
          "https://doi.org/10.1038/ncb3164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvg.20566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010653277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvg.20566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010653277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2006.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012581109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013338577", 
          "https://doi.org/10.1038/nature11308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2009.06.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013556901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2012.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013819722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.147835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017322814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.220413597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017838518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddq029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017850351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m508778200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017980491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4158/ep10412.ra", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018773086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2014.12.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019353628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000980", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021064886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0706953104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022381201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.01.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024745886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2014-1060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025361756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111412200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026394559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2016.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027041306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2002-220275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027950404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.2008.03273.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030176910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms4149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030610870", 
          "https://doi.org/10.1038/ncomms4149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2008.10.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033969669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddt484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035541458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/msb.2013.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035624405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/msb.2013.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035624405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2013.07.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036701212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2011.05.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037120224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvg.20231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042158533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-0580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042369061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.20.9063-9072.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042790477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0909471106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043923548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/jme-11-0011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047499314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/18.21.5931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049664537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0044171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050507003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0109523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053591780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2006-950500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057466828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.277756.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060407280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.2000230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062682120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-1509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.2008-0039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064285944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2005-1301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064288639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2008-0631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064290654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2011-3000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064293255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.82.9.3054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064299807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.16.3.630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064327004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.15.1.0577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064332057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.16.3.0793", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064332303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074525948", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-0593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077108286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1993.tb05715.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082783923"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-09-14", 
    "datePublishedReg": "2016-09-14", 
    "description": "Adrenal cortex physiology relies on functional zonation, essential for production of aldosterone by outer zona glomerulosa (ZG) and glucocorticoids by inner zona fasciculata (ZF). The cortex undergoes constant cell renewal, involving recruitment of subcapsular progenitors to ZG fate and subsequent lineage conversion to ZF identity. Here we show that WNT4 is an important driver of WNT pathway activation and subsequent ZG differentiation and demonstrate that PKA activation prevents ZG differentiation through WNT4 repression and WNT pathway inhibition. This suggests that PKA activation in ZF is a key driver of WNT inhibition and lineage conversion. Furthermore, we provide evidence that constitutive PKA activation inhibits, whereas partial inactivation of PKA catalytic activity stimulates \u03b2-catenin-induced tumorigenesis. Together, both lower PKA activity and higher WNT pathway activity lead to poorer prognosis in adrenocortical carcinoma (ACC) patients. These observations suggest that PKA acts as a tumour suppressor in the adrenal cortex, through repression of WNT signalling.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms12751", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4247092", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2725681", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3798455", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4247209", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development", 
    "pagination": "12751", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a8e8d9511530f501643733e0b132e61cee96216c381e82db45177e627760ceca"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27624192"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms12751"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035458600"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms12751", 
      "https://app.dimensions.ai/details/publication/pub.1035458600"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ncomms/2016/160914/ncomms12751/full/ncomms12751.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms12751'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms12751'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms12751'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms12751'


 

This table displays all metadata directly associated to this object as RDF triples.

429 TRIPLES      21 PREDICATES      92 URIs      33 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms12751 schema:about N0e412c6bc1f849f5864dae1369329c74
2 N2a687275e988440eaad46688085dbb81
3 N32d089949e914c9ea95cc9d6adc051e4
4 N3b42706bfe1b4ec992de815460997f56
5 N4625aaab288049eeb92812f44b4d8871
6 N4a943df1f6b142ab947d5b580e1b3f3e
7 N4d9eb3f234a3414880786c83e9b1ec46
8 N4dce2e0336ad47bfb65da806bc416693
9 N4f636ad66a824e19a4a51754979acca4
10 N7feadcc9994a4182ae09fbeb06f05bda
11 N91f788fbf35b48d891a3947e103acdf4
12 N9745df15cb054181946e515e5f8cc5f0
13 N9c195dc8a25046918cdbea8176120c75
14 Ndb5e2e16d04a4ea6bbc167ea407e2695
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N9f57f29094264981afbc46fbb58dd477
18 schema:citation sg:pub.10.1038/nature11308
19 sg:pub.10.1038/ncb3164
20 sg:pub.10.1038/ncomms4149
21 sg:pub.10.1038/ng1330
22 https://app.dimensions.ai/details/publication/pub.1074525948
23 https://doi.org/10.1002/dvg.20231
24 https://doi.org/10.1002/dvg.20335
25 https://doi.org/10.1002/dvg.20566
26 https://doi.org/10.1002/j.1460-2075.1993.tb05715.x
27 https://doi.org/10.1016/j.ccell.2016.04.002
28 https://doi.org/10.1016/j.cell.2006.01.053
29 https://doi.org/10.1016/j.devcel.2006.03.015
30 https://doi.org/10.1016/j.devcel.2013.07.016
31 https://doi.org/10.1016/j.mce.2008.10.045
32 https://doi.org/10.1016/j.mce.2012.04.004
33 https://doi.org/10.1016/j.mce.2014.12.014
34 https://doi.org/10.1016/j.molcel.2011.05.014
35 https://doi.org/10.1016/j.yexcr.2009.06.021
36 https://doi.org/10.1038/msb.2013.12
37 https://doi.org/10.1055/s-2006-950500
38 https://doi.org/10.1073/pnas.0706953104
39 https://doi.org/10.1073/pnas.0909471106
40 https://doi.org/10.1073/pnas.220413597
41 https://doi.org/10.1074/jbc.m111412200
42 https://doi.org/10.1074/jbc.m508778200
43 https://doi.org/10.1093/emboj/18.21.5931
44 https://doi.org/10.1093/hmg/ddq029
45 https://doi.org/10.1093/hmg/ddt484
46 https://doi.org/10.1101/gad.277756.116
47 https://doi.org/10.1111/j.1365-2265.2008.03273.x
48 https://doi.org/10.1126/scisignal.2000230
49 https://doi.org/10.1128/mcb.25.20.9063-9072.2005
50 https://doi.org/10.1158/0008-5472.can-05-0580
51 https://doi.org/10.1158/0008-5472.can-05-0593
52 https://doi.org/10.1210/en.2002-220275
53 https://doi.org/10.1210/en.2006-1509
54 https://doi.org/10.1210/er.2008-0039
55 https://doi.org/10.1210/jc.2005-1301
56 https://doi.org/10.1210/jc.2008-0631
57 https://doi.org/10.1210/jc.2011-3000
58 https://doi.org/10.1210/jc.82.9.3054
59 https://doi.org/10.1210/me.16.3.630
60 https://doi.org/10.1210/me.2014-1060
61 https://doi.org/10.1210/mend.15.1.0577
62 https://doi.org/10.1210/mend.16.3.0793
63 https://doi.org/10.1242/jcs.147835
64 https://doi.org/10.1371/journal.pgen.1000980
65 https://doi.org/10.1371/journal.pone.0044171
66 https://doi.org/10.1371/journal.pone.0109523
67 https://doi.org/10.1530/jme-11-0011
68 https://doi.org/10.4158/ep10412.ra
69 schema:datePublished 2016-09-14
70 schema:datePublishedReg 2016-09-14
71 schema:description Adrenal cortex physiology relies on functional zonation, essential for production of aldosterone by outer zona glomerulosa (ZG) and glucocorticoids by inner zona fasciculata (ZF). The cortex undergoes constant cell renewal, involving recruitment of subcapsular progenitors to ZG fate and subsequent lineage conversion to ZF identity. Here we show that WNT4 is an important driver of WNT pathway activation and subsequent ZG differentiation and demonstrate that PKA activation prevents ZG differentiation through WNT4 repression and WNT pathway inhibition. This suggests that PKA activation in ZF is a key driver of WNT inhibition and lineage conversion. Furthermore, we provide evidence that constitutive PKA activation inhibits, whereas partial inactivation of PKA catalytic activity stimulates β-catenin-induced tumorigenesis. Together, both lower PKA activity and higher WNT pathway activity lead to poorer prognosis in adrenocortical carcinoma (ACC) patients. These observations suggest that PKA acts as a tumour suppressor in the adrenal cortex, through repression of WNT signalling.
72 schema:genre research_article
73 schema:inLanguage en
74 schema:isAccessibleForFree true
75 schema:isPartOf Nd39c171ecc784615ae08e3b85032ed3f
76 sg:journal.1043282
77 schema:name PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
78 schema:pagination 12751
79 schema:productId N1392439bffd64116a2a7d61d6cdb4acb
80 N2e223f1b4fc541819fc3e4cf4a158da7
81 N57433c7f042b48a9ab4dafeda4aaae7e
82 Na0a48736c383421aa64f24ef354c2547
83 Nbbe96c9f6e1a4edba1ce85a20190bdda
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035458600
85 https://doi.org/10.1038/ncomms12751
86 schema:sdDatePublished 2019-04-10T15:58
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher N9d274c18831a415787188894f118af0f
89 schema:url http://www.nature.com/ncomms/2016/160914/ncomms12751/full/ncomms12751.html
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N03a2f1b50a424c4c9fc245a279a73a3e rdf:first sg:person.01371557114.16
94 rdf:rest N14567c8a3a524b9ab0d21e8a7cca5f93
95 N0477af7e868147baa68203558b284ba1 rdf:first sg:person.01107706210.41
96 rdf:rest N1984a3f41bcf49fab35e8e73f1928dcb
97 N072fee939db94b929b193715218c2f33 rdf:first sg:person.01130505267.24
98 rdf:rest Na2597f3484ca43cbacfb9142691505a5
99 N0e412c6bc1f849f5864dae1369329c74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Zona Glomerulosa
101 rdf:type schema:DefinedTerm
102 N1392439bffd64116a2a7d61d6cdb4acb schema:name readcube_id
103 schema:value a8e8d9511530f501643733e0b132e61cee96216c381e82db45177e627760ceca
104 rdf:type schema:PropertyValue
105 N14567c8a3a524b9ab0d21e8a7cca5f93 rdf:first sg:person.01107250557.01
106 rdf:rest rdf:nil
107 N18833bbcbee24b1fbe1f1ecb79b70c7a rdf:first sg:person.01076077641.00
108 rdf:rest N2a3e4189a59c47b1a8db946a2977d9f6
109 N1984a3f41bcf49fab35e8e73f1928dcb rdf:first sg:person.0615170555.02
110 rdf:rest N333d01913f8e4530bc5e07a504da45e3
111 N27d5958c371e4167ad59a4a306590e03 rdf:first sg:person.0703671367.15
112 rdf:rest Nb0babb2cbcd24a719b9e29154feaa46a
113 N2a3e4189a59c47b1a8db946a2977d9f6 rdf:first sg:person.01206077604.81
114 rdf:rest N62ee62b14e854dd79b861d06a8c791dd
115 N2a687275e988440eaad46688085dbb81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Cell Differentiation
117 rdf:type schema:DefinedTerm
118 N2e223f1b4fc541819fc3e4cf4a158da7 schema:name pubmed_id
119 schema:value 27624192
120 rdf:type schema:PropertyValue
121 N32d089949e914c9ea95cc9d6adc051e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Female
123 rdf:type schema:DefinedTerm
124 N333d01913f8e4530bc5e07a504da45e3 rdf:first sg:person.015105677677.40
125 rdf:rest Nd96f65d69c884d14b62d1f5566e3bb59
126 N3b0ee3ecd1894513beeb9c5e7a8f4ab7 rdf:first sg:person.0663662016.17
127 rdf:rest N0477af7e868147baa68203558b284ba1
128 N3b42706bfe1b4ec992de815460997f56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cyclic AMP-Dependent Protein Kinases
130 rdf:type schema:DefinedTerm
131 N4625aaab288049eeb92812f44b4d8871 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Wnt Signaling Pathway
133 rdf:type schema:DefinedTerm
134 N4a943df1f6b142ab947d5b580e1b3f3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Mice
136 rdf:type schema:DefinedTerm
137 N4d9eb3f234a3414880786c83e9b1ec46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Humans
139 rdf:type schema:DefinedTerm
140 N4dce2e0336ad47bfb65da806bc416693 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Adrenal Gland Neoplasms
142 rdf:type schema:DefinedTerm
143 N4f636ad66a824e19a4a51754979acca4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Animals
145 rdf:type schema:DefinedTerm
146 N57433c7f042b48a9ab4dafeda4aaae7e schema:name nlm_unique_id
147 schema:value 101528555
148 rdf:type schema:PropertyValue
149 N60a63207f9874f69adf09eb9c2a5691f rdf:first sg:person.01276420514.86
150 rdf:rest N8ae1f5da10df403aa42c12cd4d018fba
151 N62ee62b14e854dd79b861d06a8c791dd rdf:first sg:person.0771144604.36
152 rdf:rest N27d5958c371e4167ad59a4a306590e03
153 N7feadcc9994a4182ae09fbeb06f05bda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Zona Fasciculata
155 rdf:type schema:DefinedTerm
156 N8ae1f5da10df403aa42c12cd4d018fba rdf:first sg:person.0674331441.40
157 rdf:rest Nfc3b850703c646bab61d5874b8521784
158 N91f788fbf35b48d891a3947e103acdf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Cell Line, Tumor
160 rdf:type schema:DefinedTerm
161 N9745df15cb054181946e515e5f8cc5f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Phosphorylation
163 rdf:type schema:DefinedTerm
164 N9c195dc8a25046918cdbea8176120c75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name beta Catenin
166 rdf:type schema:DefinedTerm
167 N9d274c18831a415787188894f118af0f schema:name Springer Nature - SN SciGraph project
168 rdf:type schema:Organization
169 N9f57f29094264981afbc46fbb58dd477 rdf:first sg:person.01062372067.75
170 rdf:rest N072fee939db94b929b193715218c2f33
171 Na0a48736c383421aa64f24ef354c2547 schema:name dimensions_id
172 schema:value pub.1035458600
173 rdf:type schema:PropertyValue
174 Na2597f3484ca43cbacfb9142691505a5 rdf:first sg:person.01324375171.82
175 rdf:rest N18833bbcbee24b1fbe1f1ecb79b70c7a
176 Nb0babb2cbcd24a719b9e29154feaa46a rdf:first sg:person.016137532115.04
177 rdf:rest N3b0ee3ecd1894513beeb9c5e7a8f4ab7
178 Nbbe96c9f6e1a4edba1ce85a20190bdda schema:name doi
179 schema:value 10.1038/ncomms12751
180 rdf:type schema:PropertyValue
181 Nd39c171ecc784615ae08e3b85032ed3f schema:volumeNumber 7
182 rdf:type schema:PublicationVolume
183 Nd96f65d69c884d14b62d1f5566e3bb59 rdf:first sg:person.01104210067.27
184 rdf:rest N60a63207f9874f69adf09eb9c2a5691f
185 Ndb5e2e16d04a4ea6bbc167ea407e2695 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Carcinogenesis
187 rdf:type schema:DefinedTerm
188 Ne53ecd69ac594c41b74c3ed3cab41fad rdf:first sg:person.011151216517.08
189 rdf:rest N03a2f1b50a424c4c9fc245a279a73a3e
190 Nfc3b850703c646bab61d5874b8521784 rdf:first sg:person.01104050527.38
191 rdf:rest Ne53ecd69ac594c41b74c3ed3cab41fad
192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical and Health Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
196 schema:name Oncology and Carcinogenesis
197 rdf:type schema:DefinedTerm
198 sg:grant.2725681 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12751
199 rdf:type schema:MonetaryGrant
200 sg:grant.3798455 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12751
201 rdf:type schema:MonetaryGrant
202 sg:grant.4247092 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12751
203 rdf:type schema:MonetaryGrant
204 sg:grant.4247209 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12751
205 rdf:type schema:MonetaryGrant
206 sg:journal.1043282 schema:issn 2041-1723
207 schema:name Nature Communications
208 rdf:type schema:Periodical
209 sg:person.01062372067.75 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
210 schema:familyName Drelon
211 schema:givenName Coralie
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062372067.75
213 rdf:type schema:Person
214 sg:person.01076077641.00 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
215 schema:familyName Mathieu
216 schema:givenName Mickaël
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076077641.00
218 rdf:type schema:Person
219 sg:person.01104050527.38 schema:affiliation https://www.grid.ac/institutes/grid.461605.0
220 schema:familyName Schedl
221 schema:givenName Andreas
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104050527.38
223 rdf:type schema:Person
224 sg:person.01104210067.27 schema:affiliation https://www.grid.ac/institutes/grid.10858.34
225 schema:familyName Vainio
226 schema:givenName Seppo
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104210067.27
228 rdf:type schema:Person
229 sg:person.01107250557.01 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
230 schema:familyName Val
231 schema:givenName Pierre
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107250557.01
233 rdf:type schema:Person
234 sg:person.01107706210.41 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
235 schema:familyName Lefrançois-Martinez
236 schema:givenName Anne-Marie
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107706210.41
238 rdf:type schema:Person
239 sg:person.011151216517.08 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
240 schema:familyName Stratakis
241 schema:givenName Constantine A
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011151216517.08
243 rdf:type schema:Person
244 sg:person.01130505267.24 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
245 schema:familyName Berthon
246 schema:givenName Annabel
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130505267.24
248 rdf:type schema:Person
249 sg:person.01206077604.81 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
250 schema:familyName Dumontet
251 schema:givenName Typhanie
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206077604.81
253 rdf:type schema:Person
254 sg:person.01276420514.86 schema:affiliation https://www.grid.ac/institutes/grid.10858.34
255 schema:familyName Shan
256 schema:givenName Jingdong
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276420514.86
258 rdf:type schema:Person
259 sg:person.01324375171.82 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
260 schema:familyName Sahut-Barnola
261 schema:givenName Isabelle
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324375171.82
263 rdf:type schema:Person
264 sg:person.01371557114.16 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
265 schema:familyName Martinez
266 schema:givenName Antoine
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371557114.16
268 rdf:type schema:Person
269 sg:person.015105677677.40 schema:affiliation https://www.grid.ac/institutes/grid.410721.1
270 schema:familyName Gomez-Sanchez
271 schema:givenName Celso E
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015105677677.40
273 rdf:type schema:Person
274 sg:person.016137532115.04 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
275 schema:familyName Tabbal
276 schema:givenName Houda
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016137532115.04
278 rdf:type schema:Person
279 sg:person.0615170555.02 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
280 schema:familyName Pointud
281 schema:givenName Jean-Christophe
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615170555.02
283 rdf:type schema:Person
284 sg:person.0663662016.17 schema:affiliation https://www.grid.ac/institutes/grid.411163.0
285 schema:familyName Tauveron
286 schema:givenName Igor
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663662016.17
288 rdf:type schema:Person
289 sg:person.0674331441.40 schema:affiliation https://www.grid.ac/institutes/grid.461605.0
290 schema:familyName Sacco
291 schema:givenName Sonia
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674331441.40
293 rdf:type schema:Person
294 sg:person.0703671367.15 schema:affiliation https://www.grid.ac/institutes/grid.411163.0
295 schema:familyName Batisse-Lignier
296 schema:givenName Marie
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703671367.15
298 rdf:type schema:Person
299 sg:person.0771144604.36 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
300 schema:familyName Rodriguez
301 schema:givenName Stéphanie
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771144604.36
303 rdf:type schema:Person
304 sg:pub.10.1038/nature11308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013338577
305 https://doi.org/10.1038/nature11308
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/ncb3164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006924028
308 https://doi.org/10.1038/ncb3164
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/ncomms4149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030610870
311 https://doi.org/10.1038/ncomms4149
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/ng1330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004116928
314 https://doi.org/10.1038/ng1330
315 rdf:type schema:CreativeWork
316 https://app.dimensions.ai/details/publication/pub.1074525948 schema:CreativeWork
317 https://doi.org/10.1002/dvg.20231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042158533
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1002/dvg.20335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006785349
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1002/dvg.20566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010653277
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1002/j.1460-2075.1993.tb05715.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082783923
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.ccell.2016.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027041306
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.cell.2006.01.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024745886
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.devcel.2006.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012581109
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/j.devcel.2013.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036701212
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/j.mce.2008.10.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033969669
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.mce.2012.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013819722
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.mce.2014.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019353628
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.molcel.2011.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037120224
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.yexcr.2009.06.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013556901
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1038/msb.2013.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035624405
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1055/s-2006-950500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057466828
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1073/pnas.0706953104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022381201
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1073/pnas.0909471106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043923548
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1073/pnas.220413597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017838518
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1074/jbc.m111412200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026394559
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1074/jbc.m508778200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017980491
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1093/emboj/18.21.5931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049664537
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1093/hmg/ddq029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017850351
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1093/hmg/ddt484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035541458
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1101/gad.277756.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060407280
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1111/j.1365-2265.2008.03273.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030176910
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1126/scisignal.2000230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062682120
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1128/mcb.25.20.9063-9072.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042790477
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1158/0008-5472.can-05-0580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042369061
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1158/0008-5472.can-05-0593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077108286
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1210/en.2002-220275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027950404
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1210/en.2006-1509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248418
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1210/er.2008-0039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285944
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1210/jc.2005-1301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288639
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1210/jc.2008-0631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064290654
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1210/jc.2011-3000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293255
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1210/jc.82.9.3054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064299807
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1210/me.16.3.630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064327004
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1210/me.2014-1060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025361756
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1210/mend.15.1.0577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064332057
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1210/mend.16.3.0793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064332303
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1242/jcs.147835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017322814
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1371/journal.pgen.1000980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021064886
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1371/journal.pone.0044171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050507003
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1371/journal.pone.0109523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053591780
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1530/jme-11-0011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047499314
406 rdf:type schema:CreativeWork
407 https://doi.org/10.4158/ep10412.ra schema:sameAs https://app.dimensions.ai/details/publication/pub.1018773086
408 rdf:type schema:CreativeWork
409 https://www.grid.ac/institutes/grid.10858.34 schema:alternateName University of Oulu
410 schema:name Biocenter Oulu, Laboratory of Developmental Biology, InfoTech Oulu, Center for cell Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90220 Oulu, Finland.
411 rdf:type schema:Organization
412 https://www.grid.ac/institutes/grid.410721.1 schema:alternateName University of Mississippi Medical Center
413 schema:name Department of Medicine-Endocrinology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
414 Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center, Jackson, Mississippi 39216, USA.
415 rdf:type schema:Organization
416 https://www.grid.ac/institutes/grid.411163.0 schema:alternateName Centre Hospitalier Universitaire de Clermont-Ferrand
417 schema:name CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université, F-63171 Aubière Cedex, France.
418 Centre Hospitalier Universitaire, Service d'Endocrinologie, Faculté de Médecine, F-63000 Clermont-Ferrand, France.
419 rdf:type schema:Organization
420 https://www.grid.ac/institutes/grid.420089.7 schema:alternateName National Institute of Child Health and Human Development
421 schema:name CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université, F-63171 Aubière Cedex, France.
422 Developmental Endocrine Oncology and Genetics, Section on Genetics and Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892-1103, USA.
423 rdf:type schema:Organization
424 https://www.grid.ac/institutes/grid.4444.0 schema:alternateName French National Centre for Scientific Research
425 schema:name CNRS, UMR 6293, GReD, Inserm U1103, Clermont Université, F-63171 Aubière Cedex, France.
426 rdf:type schema:Organization
427 https://www.grid.ac/institutes/grid.461605.0 schema:alternateName Institute of Biology Valrose
428 schema:name Inserm UMR1091, CNRS UMR 7277, Institute of Biology Valrose, F-06108 Nice, France.
429 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...