Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-30

AUTHORS

Jeffrey J. Wallin, Johanna C. Bendell, Roel Funke, Mario Sznol, Konstanty Korski, Suzanne Jones, Genevive Hernandez, James Mier, Xian He, F. Stephen Hodi, Mitchell Denker, Vincent Leveque, Marta Cañamero, Galina Babitski, Hartmut Koeppen, James Ziai, Neeraj Sharma, Fabien Gaire, Daniel S. Chen, Daniel Waterkamp, Priti S. Hegde, David F. McDermott

ABSTRACT

Anti-tumour immune activation by checkpoint inhibitors leads to durable responses in a variety of cancers, but combination approaches are required to extend this benefit beyond a subset of patients. In preclinical models tumour-derived VEGF limits immune cell activity while anti-VEGF augments intra-tumoral T-cell infiltration, potentially through vascular normalization and endothelial cell activation. This study investigates how VEGF blockade with bevacizumab could potentiate PD-L1 checkpoint inhibition with atezolizumab in mRCC. Tissue collections are before treatment, after bevacizumab and after the addition of atezolizumab. We discover that intra-tumoral CD8+ T cells increase following combination treatment. A related increase is found in intra-tumoral MHC-I, Th1 and T-effector markers, and chemokines, most notably CX3CL1 (fractalkine). We also discover that the fractalkine receptor increases on peripheral CD8+ T cells with treatment. Furthermore, trafficking lymphocyte increases are observed in tumors following bevacizumab and combination treatment. These data suggest that the anti-VEGF and anti-PD-L1 combination improves antigen-specific T-cell migration. More... »

PAGES

12624

Journal

TITLE

Nature Communications

ISSUE

1

VOLUME

7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms12624

DOI

http://dx.doi.org/10.1038/ncomms12624

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050269937

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27571927


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Humanized", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B7-H1 Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bevacizumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD8-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Renal Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Synergism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Maximum Tolerated Dose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor A", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wallin", 
        "givenName": "Jeffrey J.", 
        "id": "sg:person.01317156117.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317156117.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GI Oncology Research, Drug Development Unit, Sarah Cannon Research Institute, 250 25th Avenue North, Suite 100, 37203, Nashville, Tennessee, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "GI Oncology Research, Drug Development Unit, Sarah Cannon Research Institute, 250 25th Avenue North, Suite 100, 37203, Nashville, Tennessee, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bendell", 
        "givenName": "Johanna C.", 
        "id": "sg:person.01174064377.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174064377.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Funke", 
        "givenName": "Roel", 
        "id": "sg:person.01162301363.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162301363.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Melanoma Unit, Yale Cancer Center, 06511, New Haven, Connecticut, USA", 
          "id": "http://www.grid.ac/institutes/grid.433818.5", 
          "name": [
            "Department of Internal Medicine and Melanoma Unit, Yale Cancer Center, 06511, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sznol", 
        "givenName": "Mario", 
        "id": "sg:person.0706626451.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706626451.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.424277.0", 
          "name": [
            "Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Korski", 
        "givenName": "Konstanty", 
        "id": "sg:person.0742563421.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742563421.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GI Oncology Research, Drug Development Unit, Sarah Cannon Research Institute, 250 25th Avenue North, Suite 100, 37203, Nashville, Tennessee, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "GI Oncology Research, Drug Development Unit, Sarah Cannon Research Institute, 250 25th Avenue North, Suite 100, 37203, Nashville, Tennessee, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Suzanne", 
        "id": "sg:person.014751065647.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014751065647.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hernandez", 
        "givenName": "Genevive", 
        "id": "sg:person.011614276365.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011614276365.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beth Israel Deaconess Medical Center, 330 Brookline Avenue, 02215, Boston, Massachusets, USA", 
          "id": "http://www.grid.ac/institutes/grid.239395.7", 
          "name": [
            "Beth Israel Deaconess Medical Center, 330 Brookline Avenue, 02215, Boston, Massachusets, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mier", 
        "givenName": "James", 
        "id": "sg:person.0611744151.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611744151.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Xian", 
        "id": "sg:person.013207237365.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013207237365.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana-Farber/Brigham and Women\u2019s Cancer Center, 450 Brookline Avenue, 02215, Boston, Massachusets, USA", 
          "id": "http://www.grid.ac/institutes/grid.417747.6", 
          "name": [
            "Dana-Farber/Brigham and Women\u2019s Cancer Center, 450 Brookline Avenue, 02215, Boston, Massachusets, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hodi", 
        "givenName": "F. Stephen", 
        "id": "sg:person.01057636442.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057636442.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Denker", 
        "givenName": "Mitchell", 
        "id": "sg:person.07476403663.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07476403663.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leveque", 
        "givenName": "Vincent", 
        "id": "sg:person.0635764171.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635764171.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.424277.0", 
          "name": [
            "Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ca\u00f1amero", 
        "givenName": "Marta", 
        "id": "sg:person.0735371677.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735371677.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.424277.0", 
          "name": [
            "Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Babitski", 
        "givenName": "Galina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koeppen", 
        "givenName": "Hartmut", 
        "id": "sg:person.010420475637.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010420475637.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ziai", 
        "givenName": "James", 
        "id": "sg:person.01113437041.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113437041.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sharma", 
        "givenName": "Neeraj", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.424277.0", 
          "name": [
            "Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gaire", 
        "givenName": "Fabien", 
        "id": "sg:person.01005716053.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005716053.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Daniel S.", 
        "id": "sg:person.01322305502.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322305502.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waterkamp", 
        "givenName": "Daniel", 
        "id": "sg:person.01013006017.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013006017.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hegde", 
        "givenName": "Priti S.", 
        "id": "sg:person.01027574444.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027574444.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beth Israel Deaconess Medical Center, 330 Brookline Avenue, 02215, Boston, Massachusets, USA", 
          "id": "http://www.grid.ac/institutes/grid.239395.7", 
          "name": [
            "Beth Israel Deaconess Medical Center, 330 Brookline Avenue, 02215, Boston, Massachusets, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McDermott", 
        "givenName": "David F.", 
        "id": "sg:person.0656541200.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656541200.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature14011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041312915", 
          "https://doi.org/10.1038/nature14011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms3680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029134323", 
          "https://doi.org/10.1038/ncomms3680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncponc0342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024004766", 
          "https://doi.org/10.1038/ncponc0342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2009.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042612538", 
          "https://doi.org/10.1038/mi.2009.112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039587457", 
          "https://doi.org/10.1038/nm.3541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009869790", 
          "https://doi.org/10.1038/nm.2883"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-08-30", 
    "datePublishedReg": "2016-08-30", 
    "description": "Anti-tumour immune activation by checkpoint inhibitors leads to durable responses in a variety of cancers, but combination approaches are required to extend this benefit beyond a subset of patients. In preclinical models tumour-derived VEGF limits immune cell activity while anti-VEGF augments intra-tumoral T-cell infiltration, potentially through vascular normalization and endothelial cell activation. This study investigates how VEGF blockade with bevacizumab could potentiate PD-L1 checkpoint inhibition with atezolizumab in mRCC. Tissue collections are before treatment, after bevacizumab and after the addition of atezolizumab. We discover that intra-tumoral CD8+ T cells increase following combination treatment. A related increase is found in intra-tumoral MHC-I, Th1 and T-effector markers, and chemokines, most notably CX3CL1 (fractalkine). We also discover that the fractalkine receptor increases on peripheral CD8+ T cells with treatment. Furthermore, trafficking lymphocyte increases are observed in tumors following bevacizumab and combination treatment. These data suggest that the anti-VEGF and anti-PD-L1 combination improves antigen-specific T-cell migration.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ncomms12624", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5475983", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "antigen-specific T-cell migration", 
      "T cell migration", 
      "T cells", 
      "combination treatment", 
      "anti-tumor immune activation", 
      "PD-L1 checkpoint inhibition", 
      "metastatic renal cell carcinoma", 
      "addition of atezolizumab", 
      "intra-tumoral CD8", 
      "subset of patients", 
      "T cell infiltration", 
      "immune cell activity", 
      "renal cell carcinoma", 
      "endothelial cell activation", 
      "variety of cancers", 
      "peripheral CD8", 
      "lymphocytes increases", 
      "checkpoint inhibitors", 
      "durable responses", 
      "checkpoint inhibition", 
      "immune activation", 
      "cell carcinoma", 
      "vascular normalization", 
      "receptor increases", 
      "cell activation", 
      "atezolizumab", 
      "cell activity", 
      "L1 combination", 
      "bevacizumab", 
      "tissue collection", 
      "CD8", 
      "treatment", 
      "related increase", 
      "VEGF", 
      "activation", 
      "cells", 
      "Th1", 
      "patients", 
      "combination approach", 
      "chemokines", 
      "carcinoma", 
      "tumors", 
      "cancer", 
      "mRCC", 
      "MHC", 
      "infiltration", 
      "increase", 
      "inhibitors", 
      "inhibition", 
      "markers", 
      "migration", 
      "subset", 
      "response", 
      "combination", 
      "normalization", 
      "activity", 
      "study", 
      "benefits", 
      "addition", 
      "data", 
      "variety", 
      "collection", 
      "approach"
    ], 
    "name": "Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma", 
    "pagination": "12624", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050269937"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms12624"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27571927"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms12624", 
      "https://app.dimensions.ai/details/publication/pub.1050269937"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_709.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ncomms12624"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms12624'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms12624'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms12624'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms12624'


 

This table displays all metadata directly associated to this object as RDF triples.

393 TRIPLES      21 PREDICATES      115 URIs      101 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms12624 schema:about N06121534230d481d8dea28db8c451c39
2 N1868616ecddf46abbd636b012e33f0c9
3 N28867d87a59b45a5999acbcea703c8c3
4 N3a7d7aabd5654d19ae4697eb7e1a85bb
5 N441f6bce09f542e5b902922966df60d2
6 N4b5a2e049b80479c938395f4b3e1c441
7 N51c52e36946c4d77bb43b42d708e1437
8 N69065acdf9ac4967a9bb853a2cd72969
9 N71926927ea524e90a368e04a0d10981c
10 N734210dfe7a14e5da8c6cb61f8cedf39
11 N883f9769fdc3417eb255d83f583af3f8
12 Nabc2fca74bd144f994cc49f1701601f5
13 Nbec39bbf19784221986e915dc66e6b45
14 Nc606aee9285c4090b07a24fb8ce5480a
15 Ncfc7b188762049fca686a6096a6f46ff
16 Ne1df7655f0604a39aa79bda4d4e00040
17 Ne3f9ce62d3c447fd88588652186a6d7a
18 Ne7d14ceb42ca4581a405eed0da9d2892
19 Ne85bad78e6024deda760fa394b232fec
20 Nef3361c897c9492eb834ba9de05f5af1
21 Nf34a20b310464cda902bc2a3fe97a446
22 anzsrc-for:11
23 anzsrc-for:1107
24 schema:author N89d371e8318447bd9a8442934fdc8ac0
25 schema:citation sg:pub.10.1038/mi.2009.112
26 sg:pub.10.1038/nature14011
27 sg:pub.10.1038/ncomms3680
28 sg:pub.10.1038/ncponc0342
29 sg:pub.10.1038/nm.2883
30 sg:pub.10.1038/nm.3541
31 schema:datePublished 2016-08-30
32 schema:datePublishedReg 2016-08-30
33 schema:description Anti-tumour immune activation by checkpoint inhibitors leads to durable responses in a variety of cancers, but combination approaches are required to extend this benefit beyond a subset of patients. In preclinical models tumour-derived VEGF limits immune cell activity while anti-VEGF augments intra-tumoral T-cell infiltration, potentially through vascular normalization and endothelial cell activation. This study investigates how VEGF blockade with bevacizumab could potentiate PD-L1 checkpoint inhibition with atezolizumab in mRCC. Tissue collections are before treatment, after bevacizumab and after the addition of atezolizumab. We discover that intra-tumoral CD8+ T cells increase following combination treatment. A related increase is found in intra-tumoral MHC-I, Th1 and T-effector markers, and chemokines, most notably CX3CL1 (fractalkine). We also discover that the fractalkine receptor increases on peripheral CD8+ T cells with treatment. Furthermore, trafficking lymphocyte increases are observed in tumors following bevacizumab and combination treatment. These data suggest that the anti-VEGF and anti-PD-L1 combination improves antigen-specific T-cell migration.
34 schema:genre article
35 schema:isAccessibleForFree true
36 schema:isPartOf N57b2e672f2a1449faad0d0bed1012840
37 N784069ea50874c31ae43494adeca0c55
38 sg:journal.1043282
39 schema:keywords CD8
40 L1 combination
41 MHC
42 PD-L1 checkpoint inhibition
43 T cell infiltration
44 T cell migration
45 T cells
46 Th1
47 VEGF
48 activation
49 activity
50 addition
51 addition of atezolizumab
52 anti-tumor immune activation
53 antigen-specific T-cell migration
54 approach
55 atezolizumab
56 benefits
57 bevacizumab
58 cancer
59 carcinoma
60 cell activation
61 cell activity
62 cell carcinoma
63 cells
64 checkpoint inhibition
65 checkpoint inhibitors
66 chemokines
67 collection
68 combination
69 combination approach
70 combination treatment
71 data
72 durable responses
73 endothelial cell activation
74 immune activation
75 immune cell activity
76 increase
77 infiltration
78 inhibition
79 inhibitors
80 intra-tumoral CD8
81 lymphocytes increases
82 mRCC
83 markers
84 metastatic renal cell carcinoma
85 migration
86 normalization
87 patients
88 peripheral CD8
89 receptor increases
90 related increase
91 renal cell carcinoma
92 response
93 study
94 subset
95 subset of patients
96 tissue collection
97 treatment
98 tumors
99 variety
100 variety of cancers
101 vascular normalization
102 schema:name Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma
103 schema:pagination 12624
104 schema:productId N26304d87c0294c428511b85034a26bec
105 N4774d6ac7ed44cddba1435af8be6fbb3
106 Nbdf384d16dbd466a8d4f751b164f86ba
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050269937
108 https://doi.org/10.1038/ncomms12624
109 schema:sdDatePublished 2022-09-02T16:00
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher N739323bd86294e8a803a063a824a68cc
112 schema:url https://doi.org/10.1038/ncomms12624
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N033220928895404d879902b50daa3b16 rdf:first sg:person.014751065647.13
117 rdf:rest N913392b2f158407fbe99154dca525a53
118 N06121534230d481d8dea28db8c451c39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Antineoplastic Combined Chemotherapy Protocols
120 rdf:type schema:DefinedTerm
121 N078409c9218345e29ff7beac03b4c927 rdf:first sg:person.013207237365.12
122 rdf:rest Nfddbe5445323440e84ea904d7763e4f3
123 N0d86371d397d4b588449989c40228c91 rdf:first sg:person.07476403663.90
124 rdf:rest N21b7eae4ae2d40d2b6ec511ed2e092ea
125 N1868616ecddf46abbd636b012e33f0c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Middle Aged
127 rdf:type schema:DefinedTerm
128 N21b473c4731c4d639dada3be34e37c3b rdf:first sg:person.0706626451.72
129 rdf:rest Nf1d7ce3c38ad4d56ba633c43d4659b99
130 N21b7eae4ae2d40d2b6ec511ed2e092ea rdf:first sg:person.0635764171.18
131 rdf:rest N9fd190a5abfa4490976be51e8a2df4dc
132 N26304d87c0294c428511b85034a26bec schema:name dimensions_id
133 schema:value pub.1050269937
134 rdf:type schema:PropertyValue
135 N28867d87a59b45a5999acbcea703c8c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name B7-H1 Antigen
137 rdf:type schema:DefinedTerm
138 N2b703237018b468895221cb00bd6a276 rdf:first sg:person.01013006017.34
139 rdf:rest N3aa9d38722354042be94bd868cb28664
140 N32f9ba7c5d8e4d46a200142ce566b94d rdf:first Nbd0ad1a8c04c479cb341b02e0b0803a7
141 rdf:rest N43a42c17c88949b0bc44450494da4abb
142 N3a7d7aabd5654d19ae4697eb7e1a85bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Female
144 rdf:type schema:DefinedTerm
145 N3aa9d38722354042be94bd868cb28664 rdf:first sg:person.01027574444.74
146 rdf:rest Nd421afadec6242788c87c07ce1ccce3a
147 N43a42c17c88949b0bc44450494da4abb rdf:first sg:person.010420475637.84
148 rdf:rest Nb330b9aa571849e2a1448009e6026c5f
149 N441f6bce09f542e5b902922966df60d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Kidney Neoplasms
151 rdf:type schema:DefinedTerm
152 N4774d6ac7ed44cddba1435af8be6fbb3 schema:name doi
153 schema:value 10.1038/ncomms12624
154 rdf:type schema:PropertyValue
155 N4b5a2e049b80479c938395f4b3e1c441 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Kidney
157 rdf:type schema:DefinedTerm
158 N4d993ab5fbc64eb796ff851e1e8c7ef9 rdf:first sg:person.01162301363.56
159 rdf:rest N21b473c4731c4d639dada3be34e37c3b
160 N51c52e36946c4d77bb43b42d708e1437 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Antigens, Neoplasm
162 rdf:type schema:DefinedTerm
163 N57b2e672f2a1449faad0d0bed1012840 schema:volumeNumber 7
164 rdf:type schema:PublicationVolume
165 N667985733a99478c9049570a81946511 rdf:first sg:person.01322305502.12
166 rdf:rest N2b703237018b468895221cb00bd6a276
167 N69065acdf9ac4967a9bb853a2cd72969 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Bevacizumab
169 rdf:type schema:DefinedTerm
170 N71926927ea524e90a368e04a0d10981c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Male
172 rdf:type schema:DefinedTerm
173 N734210dfe7a14e5da8c6cb61f8cedf39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name CD8-Positive T-Lymphocytes
175 rdf:type schema:DefinedTerm
176 N739323bd86294e8a803a063a824a68cc schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 N784069ea50874c31ae43494adeca0c55 schema:issueNumber 1
179 rdf:type schema:PublicationIssue
180 N84a1b81c40ec412caca361f4a30d98d1 rdf:first sg:person.01005716053.30
181 rdf:rest N667985733a99478c9049570a81946511
182 N883f9769fdc3417eb255d83f583af3f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Antibodies, Monoclonal
184 rdf:type schema:DefinedTerm
185 N89d371e8318447bd9a8442934fdc8ac0 rdf:first sg:person.01317156117.91
186 rdf:rest Na13885959d7a4917acd953a2389333d2
187 N8b582c1200a0439fa2fa951e6bbdeb80 rdf:first sg:person.0611744151.70
188 rdf:rest N078409c9218345e29ff7beac03b4c927
189 N913392b2f158407fbe99154dca525a53 rdf:first sg:person.011614276365.91
190 rdf:rest N8b582c1200a0439fa2fa951e6bbdeb80
191 N95a262c0f3434a6a88b556a97eab605f schema:affiliation grid-institutes:grid.418158.1
192 schema:familyName Sharma
193 schema:givenName Neeraj
194 rdf:type schema:Person
195 N9fd190a5abfa4490976be51e8a2df4dc rdf:first sg:person.0735371677.41
196 rdf:rest N32f9ba7c5d8e4d46a200142ce566b94d
197 Na13885959d7a4917acd953a2389333d2 rdf:first sg:person.01174064377.38
198 rdf:rest N4d993ab5fbc64eb796ff851e1e8c7ef9
199 Nabc2fca74bd144f994cc49f1701601f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Drug Synergism
201 rdf:type schema:DefinedTerm
202 Nb330b9aa571849e2a1448009e6026c5f rdf:first sg:person.01113437041.99
203 rdf:rest Nf6d62520c31f43ef89d5a78656f040ab
204 Nbd0ad1a8c04c479cb341b02e0b0803a7 schema:affiliation grid-institutes:grid.424277.0
205 schema:familyName Babitski
206 schema:givenName Galina
207 rdf:type schema:Person
208 Nbdf384d16dbd466a8d4f751b164f86ba schema:name pubmed_id
209 schema:value 27571927
210 rdf:type schema:PropertyValue
211 Nbec39bbf19784221986e915dc66e6b45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Vascular Endothelial Growth Factor A
213 rdf:type schema:DefinedTerm
214 Nc606aee9285c4090b07a24fb8ce5480a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Treatment Outcome
216 rdf:type schema:DefinedTerm
217 Ncfc7b188762049fca686a6096a6f46ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Antibodies, Monoclonal, Humanized
219 rdf:type schema:DefinedTerm
220 Nd421afadec6242788c87c07ce1ccce3a rdf:first sg:person.0656541200.82
221 rdf:rest rdf:nil
222 Ne1df7655f0604a39aa79bda4d4e00040 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Carcinoma, Renal Cell
224 rdf:type schema:DefinedTerm
225 Ne3f9ce62d3c447fd88588652186a6d7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Cell Movement
227 rdf:type schema:DefinedTerm
228 Ne7d14ceb42ca4581a405eed0da9d2892 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
229 schema:name Adult
230 rdf:type schema:DefinedTerm
231 Ne85bad78e6024deda760fa394b232fec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name Humans
233 rdf:type schema:DefinedTerm
234 Nef3361c897c9492eb834ba9de05f5af1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Maximum Tolerated Dose
236 rdf:type schema:DefinedTerm
237 Nf1d7ce3c38ad4d56ba633c43d4659b99 rdf:first sg:person.0742563421.54
238 rdf:rest N033220928895404d879902b50daa3b16
239 Nf34a20b310464cda902bc2a3fe97a446 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Aged
241 rdf:type schema:DefinedTerm
242 Nf6d62520c31f43ef89d5a78656f040ab rdf:first N95a262c0f3434a6a88b556a97eab605f
243 rdf:rest N84a1b81c40ec412caca361f4a30d98d1
244 Nfddbe5445323440e84ea904d7763e4f3 rdf:first sg:person.01057636442.12
245 rdf:rest N0d86371d397d4b588449989c40228c91
246 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
247 schema:name Medical and Health Sciences
248 rdf:type schema:DefinedTerm
249 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
250 schema:name Immunology
251 rdf:type schema:DefinedTerm
252 sg:grant.5475983 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12624
253 rdf:type schema:MonetaryGrant
254 sg:journal.1043282 schema:issn 2041-1723
255 schema:name Nature Communications
256 schema:publisher Springer Nature
257 rdf:type schema:Periodical
258 sg:person.01005716053.30 schema:affiliation grid-institutes:grid.424277.0
259 schema:familyName Gaire
260 schema:givenName Fabien
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005716053.30
262 rdf:type schema:Person
263 sg:person.01013006017.34 schema:affiliation grid-institutes:grid.418158.1
264 schema:familyName Waterkamp
265 schema:givenName Daniel
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013006017.34
267 rdf:type schema:Person
268 sg:person.01027574444.74 schema:affiliation grid-institutes:grid.418158.1
269 schema:familyName Hegde
270 schema:givenName Priti S.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027574444.74
272 rdf:type schema:Person
273 sg:person.010420475637.84 schema:affiliation grid-institutes:grid.418158.1
274 schema:familyName Koeppen
275 schema:givenName Hartmut
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010420475637.84
277 rdf:type schema:Person
278 sg:person.01057636442.12 schema:affiliation grid-institutes:grid.417747.6
279 schema:familyName Hodi
280 schema:givenName F. Stephen
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057636442.12
282 rdf:type schema:Person
283 sg:person.01113437041.99 schema:affiliation grid-institutes:grid.418158.1
284 schema:familyName Ziai
285 schema:givenName James
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113437041.99
287 rdf:type schema:Person
288 sg:person.011614276365.91 schema:affiliation grid-institutes:grid.418158.1
289 schema:familyName Hernandez
290 schema:givenName Genevive
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011614276365.91
292 rdf:type schema:Person
293 sg:person.01162301363.56 schema:affiliation grid-institutes:grid.418158.1
294 schema:familyName Funke
295 schema:givenName Roel
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162301363.56
297 rdf:type schema:Person
298 sg:person.01174064377.38 schema:affiliation grid-institutes:None
299 schema:familyName Bendell
300 schema:givenName Johanna C.
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174064377.38
302 rdf:type schema:Person
303 sg:person.01317156117.91 schema:affiliation grid-institutes:grid.418158.1
304 schema:familyName Wallin
305 schema:givenName Jeffrey J.
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317156117.91
307 rdf:type schema:Person
308 sg:person.013207237365.12 schema:affiliation grid-institutes:grid.418158.1
309 schema:familyName He
310 schema:givenName Xian
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013207237365.12
312 rdf:type schema:Person
313 sg:person.01322305502.12 schema:affiliation grid-institutes:grid.418158.1
314 schema:familyName Chen
315 schema:givenName Daniel S.
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322305502.12
317 rdf:type schema:Person
318 sg:person.014751065647.13 schema:affiliation grid-institutes:None
319 schema:familyName Jones
320 schema:givenName Suzanne
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014751065647.13
322 rdf:type schema:Person
323 sg:person.0611744151.70 schema:affiliation grid-institutes:grid.239395.7
324 schema:familyName Mier
325 schema:givenName James
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611744151.70
327 rdf:type schema:Person
328 sg:person.0635764171.18 schema:affiliation grid-institutes:grid.418158.1
329 schema:familyName Leveque
330 schema:givenName Vincent
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635764171.18
332 rdf:type schema:Person
333 sg:person.0656541200.82 schema:affiliation grid-institutes:grid.239395.7
334 schema:familyName McDermott
335 schema:givenName David F.
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656541200.82
337 rdf:type schema:Person
338 sg:person.0706626451.72 schema:affiliation grid-institutes:grid.433818.5
339 schema:familyName Sznol
340 schema:givenName Mario
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706626451.72
342 rdf:type schema:Person
343 sg:person.0735371677.41 schema:affiliation grid-institutes:grid.424277.0
344 schema:familyName Cañamero
345 schema:givenName Marta
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735371677.41
347 rdf:type schema:Person
348 sg:person.0742563421.54 schema:affiliation grid-institutes:grid.424277.0
349 schema:familyName Korski
350 schema:givenName Konstanty
351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742563421.54
352 rdf:type schema:Person
353 sg:person.07476403663.90 schema:affiliation grid-institutes:grid.418158.1
354 schema:familyName Denker
355 schema:givenName Mitchell
356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07476403663.90
357 rdf:type schema:Person
358 sg:pub.10.1038/mi.2009.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042612538
359 https://doi.org/10.1038/mi.2009.112
360 rdf:type schema:CreativeWork
361 sg:pub.10.1038/nature14011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041312915
362 https://doi.org/10.1038/nature14011
363 rdf:type schema:CreativeWork
364 sg:pub.10.1038/ncomms3680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029134323
365 https://doi.org/10.1038/ncomms3680
366 rdf:type schema:CreativeWork
367 sg:pub.10.1038/ncponc0342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024004766
368 https://doi.org/10.1038/ncponc0342
369 rdf:type schema:CreativeWork
370 sg:pub.10.1038/nm.2883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009869790
371 https://doi.org/10.1038/nm.2883
372 rdf:type schema:CreativeWork
373 sg:pub.10.1038/nm.3541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039587457
374 https://doi.org/10.1038/nm.3541
375 rdf:type schema:CreativeWork
376 grid-institutes:None schema:alternateName GI Oncology Research, Drug Development Unit, Sarah Cannon Research Institute, 250 25th Avenue North, Suite 100, 37203, Nashville, Tennessee, USA
377 schema:name GI Oncology Research, Drug Development Unit, Sarah Cannon Research Institute, 250 25th Avenue North, Suite 100, 37203, Nashville, Tennessee, USA
378 rdf:type schema:Organization
379 grid-institutes:grid.239395.7 schema:alternateName Beth Israel Deaconess Medical Center, 330 Brookline Avenue, 02215, Boston, Massachusets, USA
380 schema:name Beth Israel Deaconess Medical Center, 330 Brookline Avenue, 02215, Boston, Massachusets, USA
381 rdf:type schema:Organization
382 grid-institutes:grid.417747.6 schema:alternateName Dana-Farber/Brigham and Women’s Cancer Center, 450 Brookline Avenue, 02215, Boston, Massachusets, USA
383 schema:name Dana-Farber/Brigham and Women’s Cancer Center, 450 Brookline Avenue, 02215, Boston, Massachusets, USA
384 rdf:type schema:Organization
385 grid-institutes:grid.418158.1 schema:alternateName Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA
386 schema:name Genentech, Inc., 1 DNA Way, 94080, South San Francisco, California, USA
387 rdf:type schema:Organization
388 grid-institutes:grid.424277.0 schema:alternateName Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany
389 schema:name Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany
390 rdf:type schema:Organization
391 grid-institutes:grid.433818.5 schema:alternateName Department of Internal Medicine and Melanoma Unit, Yale Cancer Center, 06511, New Haven, Connecticut, USA
392 schema:name Department of Internal Medicine and Melanoma Unit, Yale Cancer Center, 06511, New Haven, Connecticut, USA
393 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...