Regulation of monocyte cell fate by blood vessels mediated by Notch signalling View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-31

AUTHORS

Jaba Gamrekelashvili, Roberto Giagnorio, Jasmin Jussofie, Oliver Soehnlein, Johan Duchene, Carlos G. Briseño, Saravana K. Ramasamy, Kashyap Krishnasamy, Anne Limbourg, Christine Häger, Tamar Kapanadze, Chieko Ishifune, Rabea Hinkel, Freddy Radtke, Lothar J. Strobl, Ursula Zimber-Strobl, L. Christian Napp, Johann Bauersachs, Hermann Haller, Koji Yasutomo, Christian Kupatt, Kenneth M. Murphy, Ralf H. Adams, Christian Weber, Florian P. Limbourg

ABSTRACT

A population of monocytes, known as Ly6Clo monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion strategies and cell-fate tracking experiments we show that Notch2 regulates conversion of Ly6Chi monocytes into Ly6Clo monocytes in vivo and in vitro, thereby regulating monocyte cell fate under steady-state conditions. This process is controlled by Notch ligand delta-like 1 (Dll1) expressed by a population of endothelial cells that constitute distinct vascular niches in the bone marrow and spleen in vivo, while culture on recombinant DLL1 induces monocyte conversion in vitro. Thus, blood vessels regulate monocyte conversion, a form of committed myeloid cell fate regulation. More... »

PAGES

12597

References to SciGraph publications

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  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    7

    Author Affiliations

  • Department of Nephrology and Hypertension, Hannover Medical School, D 30625, Hannover, Germany
  • Integrated Research and Treatment Center Transplantation, Hannover Medical School, D 30625, Hannover, Germany
  • Present address: Department of Cardiology, Universitätsklinikum Düsseldorf, D 40225 Düsseldorf, Germany.
  • German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany
  • Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, D 80336, Munich, Germany
  • Department of Pathology and Immunology, Washington University in St Louis, School of Medicine, 63110, St Louis, Missouri, USA
  • Max Planck Institute for Molecular Biomedicine, D 48149, Muenster, Germany
  • Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, D 30625, Hannover, Germany
  • Present address: Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover D 30625, Germany.
  • Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, 770-8503, Tokushima, Japan
  • Medizinische Klinik I, Klinikum Rechts der Isar, Technical University of Munich, D 81675, Munich, Germany
  • Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, ISREC, CH 1015, Lausanne, Switzerland
  • Research Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH), D 81377, Munich, Germany
  • Department of Cardiology, Hannover Medical School, D 30625, Hannover, Germany
  • Howard Hughes Medical Institute, Washington University in St Louis, School of Medicine, St Louis, Missouri, USA
  • Cardiovascular Research Institute Maastricht (CARIM), 6229 ER, Maastricht, The Netherlands
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms12597

    DOI

    http://dx.doi.org/10.1038/ncomms12597

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001058058

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27576369


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