Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-09

AUTHORS

Christopher A. Miller, Yevgeniy Gindin, Charles Lu, Obi L Griffith, Malachi Griffith, Dong Shen, Jeremy Hoog, Tiandao Li, David E. Larson, Mark Watson, Sherri R Davies, Kelly Hunt, Vera J. Suman, Jacqueline Snider, Thomas Walsh, Graham A. Colditz, Katherine DeSchryver, Richard K. Wilson, Elaine R. Mardis, Matthew J. Ellis

ABSTRACT

Resistance to oestrogen-deprivation therapy is common in oestrogen-receptor-positive (ER+) breast cancer. To better understand the contributions of tumour heterogeneity and evolution to resistance, here we perform comprehensive genomic characterization of 22 primary tumours sampled before and after 4 months of neoadjuvant aromatase inhibitor (NAI) treatment. Comparing whole-genome sequencing of tumour/normal pairs from the two time points, with coincident tumour RNA sequencing, reveals widespread spatial and temporal heterogeneity, with marked remodelling of the clonal landscape in response to NAI. Two cases have genomic evidence of two independent tumours, most obviously an ER- 'collision tumour', which was only detected after NAI treatment of baseline ER+ disease. Many mutations are newly detected or enriched post treatment, including two ligand-binding domain mutations in ESR1. The observed clonal complexity of the ER+ breast cancer genome suggests that precision medicine approaches based on genomic analysis of a single specimen are likely insufficient to capture all clinically significant information. More... »

PAGES

12498

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms12498

DOI

http://dx.doi.org/10.1038/ncomms12498

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034470951

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27502118


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aromatase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aromatase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clone Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Medicine, Division of Genomics and Bioinformatics, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miller", 
        "givenName": "Christopher A.", 
        "id": "sg:person.01015365433.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015365433.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gindin", 
        "givenName": "Yevgeniy", 
        "id": "sg:person.01147607043.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147607043.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Charles", 
        "id": "sg:person.01041130405.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041130405.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Griffith", 
        "givenName": "Obi L", 
        "id": "sg:person.0762032250.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762032250.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Griffith", 
        "givenName": "Malachi", 
        "id": "sg:person.0670670604.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670670604.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Dong", 
        "id": "sg:person.0656360600.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656360600.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoog", 
        "givenName": "Jeremy", 
        "id": "sg:person.0632646001.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632646001.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Tiandao", 
        "id": "sg:person.0612234303.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612234303.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larson", 
        "givenName": "David E.", 
        "id": "sg:person.0623362425.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623362425.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watson", 
        "givenName": "Mark", 
        "id": "sg:person.011243173122.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011243173122.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davies", 
        "givenName": "Sherri R", 
        "id": "sg:person.016237511257.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016237511257.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Breast Surgery, MD Anderson Cancer Center, Houston, Texas 77030, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hunt", 
        "givenName": "Kelly", 
        "id": "sg:person.01340214713.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340214713.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Alliance Statistics and Data Center, Mayo Clinic, Rochester, Minnesota 55905, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suman", 
        "givenName": "Vera J.", 
        "id": "sg:person.01033332204.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033332204.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Snider", 
        "givenName": "Jacqueline", 
        "id": "sg:person.01314071520.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314071520.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Surgery, Division of Public Health, St Louis Breast Tissue Registry, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walsh", 
        "givenName": "Thomas", 
        "id": "sg:person.011513100165.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011513100165.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Surgery, Division of Public Health, St Louis Breast Tissue Registry, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Colditz", 
        "givenName": "Graham A.", 
        "id": "sg:person.016331102737.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016331102737.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Surgery, Division of Public Health, St Louis Breast Tissue Registry, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "DeSchryver", 
        "givenName": "Katherine", 
        "id": "sg:person.0667364167.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667364167.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Medicine, Division of Genomics and Bioinformatics, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Richard K.", 
        "id": "sg:person.013076541047.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013076541047.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mardis", 
        "givenName": "Elaine R.", 
        "id": "sg:person.01023627236.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023627236.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ellis", 
        "givenName": "Matthew J.", 
        "id": "sg:person.012333564657.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012333564657.16"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1004274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000693037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000834660", 
          "https://doi.org/10.1038/nature11143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002266189", 
          "https://doi.org/10.1038/nrc3920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002400190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.10.5056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008612026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010741940", 
          "https://doi.org/10.1038/ng.2823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0575-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011069188", 
          "https://doi.org/10.1007/s10549-009-0575-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0575-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011069188", 
          "https://doi.org/10.1007/s10549-009-0575-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0575-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011069188", 
          "https://doi.org/10.1007/s10549-009-0575-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.04.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012547698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.06.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014079572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-12-0349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014499404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr1732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015413615", 
          "https://doi.org/10.1186/bcr1732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3816/cbc.2011.n.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018107077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1256930", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018285655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1256930", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018285655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.31.6950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019109042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.05.3520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019178485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0903840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019484764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019741899", 
          "https://doi.org/10.1038/ng.2822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021700659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025463660", 
          "https://doi.org/10.1038/sj.bjc.6605912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027457561", 
          "https://doi.org/10.1038/nature10933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.38.3224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027769303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djn309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028235358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.186114.114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031247349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.11.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033302817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3003854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034943640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2013.08.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039118392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040238174", 
          "https://doi.org/10.1038/nature13948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1253462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046584781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1003665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050059313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2009.01.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052812467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e32820b853a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e32820b853a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e32820b853a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.959840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062662765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.5.13.2924", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077878735", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-08-09", 
    "datePublishedReg": "2016-08-09", 
    "description": "Resistance to oestrogen-deprivation therapy is common in oestrogen-receptor-positive (ER+) breast cancer. To better understand the contributions of tumour heterogeneity and evolution to resistance, here we perform comprehensive genomic characterization of 22 primary tumours sampled before and after 4 months of neoadjuvant aromatase inhibitor (NAI) treatment. Comparing whole-genome sequencing of tumour/normal pairs from the two time points, with coincident tumour RNA sequencing, reveals widespread spatial and temporal heterogeneity, with marked remodelling of the clonal landscape in response to NAI. Two cases have genomic evidence of two independent tumours, most obviously an ER- 'collision tumour', which was only detected after NAI treatment of baseline ER+ disease. Many mutations are newly detected or enriched post treatment, including two ligand-binding domain mutations in ESR1. The observed clonal complexity of the ER+ breast cancer genome suggests that precision medicine approaches based on genomic analysis of a single specimen are likely insufficient to capture all clinically significant information.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms12498", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3535853", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2689066", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3535136", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4055153", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3804910", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3535792", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2693655", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2476078", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696307", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3537027", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7822567", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2699329", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3535030", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers", 
    "pagination": "12498", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a4350473f1b42626d294316aa0a4c71e65fe67a63b6e38955f9b780220b7b66d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27502118"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms12498"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034470951"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms12498", 
      "https://app.dimensions.ai/details/publication/pub.1034470951"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ncomms/2016/160809/ncomms12498/full/ncomms12498.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms12498'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms12498'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms12498'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms12498'


 

This table displays all metadata directly associated to this object as RDF triples.

399 TRIPLES      21 PREDICATES      73 URIs      31 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms12498 schema:about N0d44566e67c2453b8902dfbb5c9af7df
2 N184cbae40d184caaa05ec5e9c7b3019b
3 N1fffad0e204b42dea57fa2f253aa1f46
4 N4195dd67bb394d98bc06403638c03816
5 N54cf8386877a43369370b49c0a68218c
6 N595f5e9cddd042ecbf5d0e189ae0311d
7 N5c1c5d67b2a94b2b9406795538e40744
8 N76657cbdb5ea4c0fb4fefef5e9e7935b
9 N82905abdf0074072a428f4ddfa35d9d0
10 Naa986546fd764f8b99c0cc9396021b00
11 Nb80b4508d9054299bb816f73422d580e
12 Ndc63f595f66b4da4bfb807601d47988a
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author N2b461a6c476b401d8da9b9cc7d1064f0
16 schema:citation sg:pub.10.1007/s10549-009-0575-y
17 sg:pub.10.1038/nature10933
18 sg:pub.10.1038/nature11143
19 sg:pub.10.1038/nature13948
20 sg:pub.10.1038/ng.2822
21 sg:pub.10.1038/ng.2823
22 sg:pub.10.1038/nrc3920
23 sg:pub.10.1038/sj.bjc.6605912
24 sg:pub.10.1186/bcr1732
25 https://app.dimensions.ai/details/publication/pub.1077878735
26 https://doi.org/10.1002/cncr.23187
27 https://doi.org/10.1016/j.ccr.2009.11.022
28 https://doi.org/10.1016/j.cell.2012.04.023
29 https://doi.org/10.1016/j.cell.2012.06.023
30 https://doi.org/10.1016/j.celrep.2013.08.022
31 https://doi.org/10.1016/j.jamcollsurg.2009.01.035
32 https://doi.org/10.1056/nejmoa0903840
33 https://doi.org/10.1093/annonc/mds297
34 https://doi.org/10.1093/jnci/djn309
35 https://doi.org/10.1097/fpc.0b013e32820b853a
36 https://doi.org/10.1101/gr.186114.114
37 https://doi.org/10.1126/science.1253462
38 https://doi.org/10.1126/science.1256930
39 https://doi.org/10.1126/science.959840
40 https://doi.org/10.1126/scitranslmed.3003854
41 https://doi.org/10.1158/2159-8290.cd-12-0349
42 https://doi.org/10.1200/jco.2005.05.3520
43 https://doi.org/10.1200/jco.2006.10.5056
44 https://doi.org/10.1200/jco.2010.31.6950
45 https://doi.org/10.1200/jco.2011.38.3224
46 https://doi.org/10.1371/journal.pcbi.1003665
47 https://doi.org/10.1371/journal.pcbi.1004274
48 https://doi.org/10.3816/cbc.2011.n.010
49 https://doi.org/10.4161/cc.5.13.2924
50 schema:datePublished 2016-08-09
51 schema:datePublishedReg 2016-08-09
52 schema:description Resistance to oestrogen-deprivation therapy is common in oestrogen-receptor-positive (ER+) breast cancer. To better understand the contributions of tumour heterogeneity and evolution to resistance, here we perform comprehensive genomic characterization of 22 primary tumours sampled before and after 4 months of neoadjuvant aromatase inhibitor (NAI) treatment. Comparing whole-genome sequencing of tumour/normal pairs from the two time points, with coincident tumour RNA sequencing, reveals widespread spatial and temporal heterogeneity, with marked remodelling of the clonal landscape in response to NAI. Two cases have genomic evidence of two independent tumours, most obviously an ER- 'collision tumour', which was only detected after NAI treatment of baseline ER+ disease. Many mutations are newly detected or enriched post treatment, including two ligand-binding domain mutations in ESR1. The observed clonal complexity of the ER+ breast cancer genome suggests that precision medicine approaches based on genomic analysis of a single specimen are likely insufficient to capture all clinically significant information.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf Nbb4adf7186874ba19be1c938cde1bc6b
57 sg:journal.1043282
58 schema:name Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers
59 schema:pagination 12498
60 schema:productId N1c105bd022da4a4cadde6aeae7552500
61 N21593da4adbc4824b72a728a4a5f75d1
62 N2f65a529796749f7b143092a3d8619a8
63 N301c6dc7f78c495686c38147a8116d02
64 N62b448e8d1254532b893e565e2b34045
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034470951
66 https://doi.org/10.1038/ncomms12498
67 schema:sdDatePublished 2019-04-10T23:31
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N9d16219449a6461e83445fc027847b7e
70 schema:url http://www.nature.com/ncomms/2016/160809/ncomms12498/full/ncomms12498.html
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N0121d30584e543d18a8e94286a64ad7c rdf:first sg:person.013076541047.38
75 rdf:rest N1de2ccd89a3446118f1bc4c12b11f9f4
76 N0d44566e67c2453b8902dfbb5c9af7df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Cell Line, Tumor
78 rdf:type schema:DefinedTerm
79 N184cbae40d184caaa05ec5e9c7b3019b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Alleles
81 rdf:type schema:DefinedTerm
82 N1c105bd022da4a4cadde6aeae7552500 schema:name dimensions_id
83 schema:value pub.1034470951
84 rdf:type schema:PropertyValue
85 N1d6f812b1578428cba9fb41efc8c85cb rdf:first sg:person.0762032250.09
86 rdf:rest N63bfc6d726214fd8aa88293931136064
87 N1de2ccd89a3446118f1bc4c12b11f9f4 rdf:first sg:person.01023627236.33
88 rdf:rest N81f949591b2e4943acc4db666486b2cc
89 N1fffad0e204b42dea57fa2f253aa1f46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Aromatase Inhibitors
91 rdf:type schema:DefinedTerm
92 N21593da4adbc4824b72a728a4a5f75d1 schema:name nlm_unique_id
93 schema:value 101528555
94 rdf:type schema:PropertyValue
95 N2b461a6c476b401d8da9b9cc7d1064f0 rdf:first sg:person.01015365433.49
96 rdf:rest N2e81c3e1e5d448c5a72ee56b1c9a4e6e
97 N2e81c3e1e5d448c5a72ee56b1c9a4e6e rdf:first sg:person.01147607043.38
98 rdf:rest N53cf46044815413d86be4acc71e569f5
99 N2f65a529796749f7b143092a3d8619a8 schema:name pubmed_id
100 schema:value 27502118
101 rdf:type schema:PropertyValue
102 N301c6dc7f78c495686c38147a8116d02 schema:name readcube_id
103 schema:value a4350473f1b42626d294316aa0a4c71e65fe67a63b6e38955f9b780220b7b66d
104 rdf:type schema:PropertyValue
105 N4195dd67bb394d98bc06403638c03816 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Clone Cells
107 rdf:type schema:DefinedTerm
108 N4d164bd4cfc64156941a9a3837f03603 rdf:first sg:person.0632646001.51
109 rdf:rest Nc610357d2f5a490bb9b209421a8d6cff
110 N53b983b2ca09486583b58b39d973c48d rdf:first sg:person.01314071520.90
111 rdf:rest Ndd0714d8f90a481083c008e245c3b427
112 N53cf46044815413d86be4acc71e569f5 rdf:first sg:person.01041130405.40
113 rdf:rest N1d6f812b1578428cba9fb41efc8c85cb
114 N54cf8386877a43369370b49c0a68218c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Breast Neoplasms
116 rdf:type schema:DefinedTerm
117 N595f5e9cddd042ecbf5d0e189ae0311d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Mutation
119 rdf:type schema:DefinedTerm
120 N5c1c5d67b2a94b2b9406795538e40744 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Aromatase
122 rdf:type schema:DefinedTerm
123 N62b448e8d1254532b893e565e2b34045 schema:name doi
124 schema:value 10.1038/ncomms12498
125 rdf:type schema:PropertyValue
126 N63bfc6d726214fd8aa88293931136064 rdf:first sg:person.0670670604.42
127 rdf:rest N9d0d6d0e26e848c1a457f68c06f7ec57
128 N6bdbee99f3fa4c4c9cb4b13a7153d3dc rdf:first sg:person.01340214713.66
129 rdf:rest Nad74f9477e284d3083c2cf08bf802a2b
130 N76657cbdb5ea4c0fb4fefef5e9e7935b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 N81f949591b2e4943acc4db666486b2cc rdf:first sg:person.012333564657.16
134 rdf:rest rdf:nil
135 N82905abdf0074072a428f4ddfa35d9d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Female
137 rdf:type schema:DefinedTerm
138 N918e61d0d37d498e80d8ca3fadd6937b rdf:first sg:person.0667364167.11
139 rdf:rest N0121d30584e543d18a8e94286a64ad7c
140 N9c27e86823ad47cab36d9c6bd8874e17 rdf:first sg:person.016237511257.46
141 rdf:rest N6bdbee99f3fa4c4c9cb4b13a7153d3dc
142 N9d0d6d0e26e848c1a457f68c06f7ec57 rdf:first sg:person.0656360600.01
143 rdf:rest N4d164bd4cfc64156941a9a3837f03603
144 N9d16219449a6461e83445fc027847b7e schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N9ec744adf4c94bb191e7befa348dc90f rdf:first sg:person.016331102737.81
147 rdf:rest N918e61d0d37d498e80d8ca3fadd6937b
148 Naa986546fd764f8b99c0cc9396021b00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Genome, Human
150 rdf:type schema:DefinedTerm
151 Nad74f9477e284d3083c2cf08bf802a2b rdf:first sg:person.01033332204.12
152 rdf:rest N53b983b2ca09486583b58b39d973c48d
153 Nb80b4508d9054299bb816f73422d580e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Biomarkers, Tumor
155 rdf:type schema:DefinedTerm
156 Nbb4adf7186874ba19be1c938cde1bc6b schema:volumeNumber 7
157 rdf:type schema:PublicationVolume
158 Nc44f27b26a704c24be45cebb6c8cb25d rdf:first sg:person.0623362425.14
159 rdf:rest Ndd698167a792455ebc4e146363d25aaa
160 Nc610357d2f5a490bb9b209421a8d6cff rdf:first sg:person.0612234303.15
161 rdf:rest Nc44f27b26a704c24be45cebb6c8cb25d
162 Ndc63f595f66b4da4bfb807601d47988a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Receptors, Estrogen
164 rdf:type schema:DefinedTerm
165 Ndd0714d8f90a481083c008e245c3b427 rdf:first sg:person.011513100165.13
166 rdf:rest N9ec744adf4c94bb191e7befa348dc90f
167 Ndd698167a792455ebc4e146363d25aaa rdf:first sg:person.011243173122.25
168 rdf:rest N9c27e86823ad47cab36d9c6bd8874e17
169 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
170 schema:name Medical and Health Sciences
171 rdf:type schema:DefinedTerm
172 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
173 schema:name Oncology and Carcinogenesis
174 rdf:type schema:DefinedTerm
175 sg:grant.2476078 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
176 rdf:type schema:MonetaryGrant
177 sg:grant.2689066 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
178 rdf:type schema:MonetaryGrant
179 sg:grant.2693655 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
180 rdf:type schema:MonetaryGrant
181 sg:grant.2696307 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
182 rdf:type schema:MonetaryGrant
183 sg:grant.2699329 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
184 rdf:type schema:MonetaryGrant
185 sg:grant.3535030 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
186 rdf:type schema:MonetaryGrant
187 sg:grant.3535136 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
188 rdf:type schema:MonetaryGrant
189 sg:grant.3535792 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
190 rdf:type schema:MonetaryGrant
191 sg:grant.3535853 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
192 rdf:type schema:MonetaryGrant
193 sg:grant.3537027 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
194 rdf:type schema:MonetaryGrant
195 sg:grant.3804910 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
196 rdf:type schema:MonetaryGrant
197 sg:grant.4055153 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
198 rdf:type schema:MonetaryGrant
199 sg:grant.7822567 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12498
200 rdf:type schema:MonetaryGrant
201 sg:journal.1043282 schema:issn 2041-1723
202 schema:name Nature Communications
203 rdf:type schema:Periodical
204 sg:person.01015365433.49 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
205 schema:familyName Miller
206 schema:givenName Christopher A.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015365433.49
208 rdf:type schema:Person
209 sg:person.01023627236.33 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
210 schema:familyName Mardis
211 schema:givenName Elaine R.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023627236.33
213 rdf:type schema:Person
214 sg:person.01033332204.12 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
215 schema:familyName Suman
216 schema:givenName Vera J.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033332204.12
218 rdf:type schema:Person
219 sg:person.01041130405.40 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
220 schema:familyName Lu
221 schema:givenName Charles
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041130405.40
223 rdf:type schema:Person
224 sg:person.011243173122.25 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
225 schema:familyName Watson
226 schema:givenName Mark
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011243173122.25
228 rdf:type schema:Person
229 sg:person.01147607043.38 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
230 schema:familyName Gindin
231 schema:givenName Yevgeniy
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147607043.38
233 rdf:type schema:Person
234 sg:person.011513100165.13 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
235 schema:familyName Walsh
236 schema:givenName Thomas
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011513100165.13
238 rdf:type schema:Person
239 sg:person.012333564657.16 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
240 schema:familyName Ellis
241 schema:givenName Matthew J.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012333564657.16
243 rdf:type schema:Person
244 sg:person.013076541047.38 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
245 schema:familyName Wilson
246 schema:givenName Richard K.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013076541047.38
248 rdf:type schema:Person
249 sg:person.01314071520.90 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
250 schema:familyName Snider
251 schema:givenName Jacqueline
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314071520.90
253 rdf:type schema:Person
254 sg:person.01340214713.66 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
255 schema:familyName Hunt
256 schema:givenName Kelly
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340214713.66
258 rdf:type schema:Person
259 sg:person.016237511257.46 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
260 schema:familyName Davies
261 schema:givenName Sherri R
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016237511257.46
263 rdf:type schema:Person
264 sg:person.016331102737.81 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
265 schema:familyName Colditz
266 schema:givenName Graham A.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016331102737.81
268 rdf:type schema:Person
269 sg:person.0612234303.15 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
270 schema:familyName Li
271 schema:givenName Tiandao
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612234303.15
273 rdf:type schema:Person
274 sg:person.0623362425.14 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
275 schema:familyName Larson
276 schema:givenName David E.
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623362425.14
278 rdf:type schema:Person
279 sg:person.0632646001.51 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
280 schema:familyName Hoog
281 schema:givenName Jeremy
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632646001.51
283 rdf:type schema:Person
284 sg:person.0656360600.01 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
285 schema:familyName Shen
286 schema:givenName Dong
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656360600.01
288 rdf:type schema:Person
289 sg:person.0667364167.11 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
290 schema:familyName DeSchryver
291 schema:givenName Katherine
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667364167.11
293 rdf:type schema:Person
294 sg:person.0670670604.42 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
295 schema:familyName Griffith
296 schema:givenName Malachi
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670670604.42
298 rdf:type schema:Person
299 sg:person.0762032250.09 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
300 schema:familyName Griffith
301 schema:givenName Obi L
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762032250.09
303 rdf:type schema:Person
304 sg:pub.10.1007/s10549-009-0575-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1011069188
305 https://doi.org/10.1007/s10549-009-0575-y
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/nature10933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027457561
308 https://doi.org/10.1038/nature10933
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/nature11143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000834660
311 https://doi.org/10.1038/nature11143
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/nature13948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040238174
314 https://doi.org/10.1038/nature13948
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/ng.2822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019741899
317 https://doi.org/10.1038/ng.2822
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/ng.2823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010741940
320 https://doi.org/10.1038/ng.2823
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/nrc3920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002266189
323 https://doi.org/10.1038/nrc3920
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/sj.bjc.6605912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025463660
326 https://doi.org/10.1038/sj.bjc.6605912
327 rdf:type schema:CreativeWork
328 sg:pub.10.1186/bcr1732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015413615
329 https://doi.org/10.1186/bcr1732
330 rdf:type schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1077878735 schema:CreativeWork
332 https://doi.org/10.1002/cncr.23187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002400190
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/j.ccr.2009.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033302817
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1016/j.cell.2012.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012547698
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/j.cell.2012.06.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014079572
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1016/j.celrep.2013.08.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039118392
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1016/j.jamcollsurg.2009.01.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052812467
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1056/nejmoa0903840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019484764
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1093/annonc/mds297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021700659
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1093/jnci/djn309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028235358
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1097/fpc.0b013e32820b853a schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340513
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1101/gr.186114.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031247349
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1126/science.1253462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046584781
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1126/science.1256930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018285655
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1126/science.959840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062662765
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1126/scitranslmed.3003854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034943640
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1158/2159-8290.cd-12-0349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014499404
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1200/jco.2005.05.3520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019178485
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1200/jco.2006.10.5056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008612026
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1200/jco.2010.31.6950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019109042
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1200/jco.2011.38.3224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027769303
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1371/journal.pcbi.1003665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050059313
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1371/journal.pcbi.1004274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000693037
375 rdf:type schema:CreativeWork
376 https://doi.org/10.3816/cbc.2011.n.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018107077
377 rdf:type schema:CreativeWork
378 https://doi.org/10.4161/cc.5.13.2924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298512
379 rdf:type schema:CreativeWork
380 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
381 schema:name Department of Breast Surgery, MD Anderson Cancer Center, Houston, Texas 77030, USA
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.39382.33 schema:alternateName Baylor College of Medicine
384 schema:name Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA
385 Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
386 McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA
387 rdf:type schema:Organization
388 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
389 schema:name Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
390 Department of Medicine, Division of Genomics and Bioinformatics, Washington University School of Medicine, St Louis, Missouri 63108, USA
391 Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA
392 Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63108, USA
393 Department of Surgery, Division of Public Health, St Louis Breast Tissue Registry, Washington University School of Medicine, St Louis, Missouri 63108, USA
394 McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA
395 Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
396 rdf:type schema:Organization
397 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
398 schema:name Alliance Statistics and Data Center, Mayo Clinic, Rochester, Minnesota 55905, USA
399 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...