PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl, Keith W. Caldecott

ABSTRACT

PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal that PARP3 employs a conserved DNA-binding interface to detect and stably bind DNA breaks and to accumulate at sites of chromosome damage. PARP3 preferentially binds to and is activated by mononucleosomes containing nicked DNA and which target PARP3 trans-ribosylation activity to a single-histone substrate. Although nicks in naked DNA stimulate PARP3 autoribosylation, nicks in mononucleosomes promote the trans-ribosylation of histone H2B specifically at Glu2. These data identify PARP3 as a molecular sensor of nicked nucleosomes and demonstrate, for the first time, the ribosylation of chromatin at a site-specific DNA single-strand break. More... »

PAGES

12404

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms12404

DOI

http://dx.doi.org/10.1038/ncomms12404

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001987728

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27530147


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chickens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Breaks, Single-Stranded", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleosomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Poly(ADP-ribose) Polymerases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Domains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ribose", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Sussex", 
          "id": "https://www.grid.ac/institutes/grid.12082.39", 
          "name": [
            "Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grundy", 
        "givenName": "Gabrielle J.", 
        "id": "sg:person.0777023614.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777023614.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sussex", 
          "id": "https://www.grid.ac/institutes/grid.12082.39", 
          "name": [
            "Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Polo", 
        "givenName": "Luis M.", 
        "id": "sg:person.012621766065.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012621766065.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sussex", 
          "id": "https://www.grid.ac/institutes/grid.12082.39", 
          "name": [
            "Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeng", 
        "givenName": "Zhihong", 
        "id": "sg:person.01175433415.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175433415.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sussex", 
          "id": "https://www.grid.ac/institutes/grid.12082.39", 
          "name": [
            "Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rulten", 
        "givenName": "Stuart L.", 
        "id": "sg:person.01107312235.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107312235.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior", 
          "id": "https://www.grid.ac/institutes/grid.452295.d", 
          "name": [
            "Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK", 
            "CAPES Foundation, Ministry of Education of Brazil, Brasilia/DF 70040-020, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoch", 
        "givenName": "Nicolas C.", 
        "id": "sg:person.0603273634.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603273634.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sussex", 
          "id": "https://www.grid.ac/institutes/grid.12082.39", 
          "name": [
            "Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paomephan", 
        "givenName": "Pathompong", 
        "id": "sg:person.015607670065.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015607670065.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Cross-faculty NMR centre, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Yingqi", 
        "id": "sg:person.0637572111.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637572111.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sussex", 
          "id": "https://www.grid.ac/institutes/grid.12082.39", 
          "name": [
            "Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sweet", 
        "givenName": "Steve M.", 
        "id": "sg:person.0677761226.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677761226.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Portsmouth", 
          "id": "https://www.grid.ac/institutes/grid.4701.2", 
          "name": [
            "Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, St Michael\u2019s Building, Portsmouth PO1 2DT, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thorne", 
        "givenName": "Alan W.", 
        "id": "sg:person.01066624377.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066624377.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sussex", 
          "id": "https://www.grid.ac/institutes/grid.12082.39", 
          "name": [
            "Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oliver", 
        "givenName": "Antony W.", 
        "id": "sg:person.01242763420.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242763420.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Cross-faculty NMR centre, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matthews", 
        "givenName": "Steve J.", 
        "id": "sg:person.011303000117.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011303000117.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sussex", 
          "id": "https://www.grid.ac/institutes/grid.12082.39", 
          "name": [
            "Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pearl", 
        "givenName": "Laurence H.", 
        "id": "sg:person.01270302004.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270302004.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sussex", 
          "id": "https://www.grid.ac/institutes/grid.12082.39", 
          "name": [
            "Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caldecott", 
        "givenName": "Keith W.", 
        "id": "sg:person.01154767332.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154767332.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/nar/gku474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001638494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/7.3.793", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002927267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60327-058-8_14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003564079", 
          "https://doi.org/10.1007/978-1-60327-058-8_14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.8.2858-2866.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003825698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2014.03.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005445209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006358626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/o80-069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007189662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1568-7864(03)00118-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007230713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1568-7864(03)00118-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007230713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.79.11.3423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007695233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008847161", 
          "https://doi.org/10.1038/nsmb.2521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-61779-270-0_19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009310953", 
          "https://doi.org/10.1007/978-1-61779-270-0_19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2007.202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009324955", 
          "https://doi.org/10.1038/nprot.2007.202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/o78-119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011402605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gku174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014985494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1997.1494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016295630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cb4002014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016693567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2012.304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019150020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2009.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019867611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020758140", 
          "https://doi.org/10.1038/nsmb.2523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2013.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022810571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.18.5497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023693632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(85)90586-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024431445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.10.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024564479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(03)75002-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024960320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.11.3974-3981.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025641437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027601855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkg761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031640040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(92)90588-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032119799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(92)90588-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032119799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac026359i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032433726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac026359i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032433726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1016574108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033200813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036379922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2012.03.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036963078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037744158", 
          "https://doi.org/10.1038/nmeth.2603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041270694", 
          "https://doi.org/10.1038/nrg2380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043892387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2000.3531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046351919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.201000616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046562215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1977.tb11843.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046690711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0968-0004(94)90280-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047104225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0968-0004(94)90280-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047104225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00573a008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055181235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078444585", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078445461", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082349893", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal that PARP3 employs a conserved DNA-binding interface to detect and stably bind DNA breaks and to accumulate at sites of chromosome damage. PARP3 preferentially binds to and is activated by mononucleosomes containing nicked DNA and which target PARP3 trans-ribosylation activity to a single-histone substrate. Although nicks in naked DNA stimulate PARP3 autoribosylation, nicks in mononucleosomes promote the trans-ribosylation of histone H2B specifically at Glu2. These data identify PARP3 as a molecular sensor of nicked nucleosomes and demonstrate, for the first time, the ribosylation of chromatin at a site-specific DNA single-strand break.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms12404", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4578921", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2753715", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3643248", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2758894", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2783585", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4456440", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2761206", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2", 
    "pagination": "12404", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "097797eb6be560a59b3f1747748da6a268cb9fccd0e90210d4bf1c50aa9e7821"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27530147"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms12404"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001987728"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms12404", 
      "https://app.dimensions.ai/details/publication/pub.1001987728"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78968_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ncomms12404"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms12404'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms12404'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms12404'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms12404'


 

This table displays all metadata directly associated to this object as RDF triples.

370 TRIPLES      21 PREDICATES      87 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms12404 schema:about N19bd03f45b5a4970a23d20ff53d14bf7
2 N1ebc48759bf54c8ca6f696f342871e91
3 N2ab268dc4f2a4b579cbbc630564e79b0
4 N2b303a3f73cf4006aef609d9a28d40f3
5 N2f9e15926b4c4e57bde5a68d0b15c14a
6 N367c51faf8034f0badc463cc6f978b0e
7 N62f9941e93f7492f8ae021e65b5654be
8 N6915104148674d189c77c58f9012cf31
9 N76daa71ef0dc4801a2948e1bf2b6ee28
10 N8eac747f3b1f48d2b8086713d8a18474
11 N928c215d932c46b78462ccff2b47f401
12 Nb9da5a965ecf4fccb31a6ed9fcb78b33
13 Nc05fca109cfb4008961b42341b926d0e
14 Nca29217ac37041759432657a990fbc0c
15 Ndf02d69d1cac47ed86ad9bda27095626
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author Ne5fab88064b449fab0a702de81ac873b
19 schema:citation sg:pub.10.1007/978-1-60327-058-8_14
20 sg:pub.10.1007/978-1-61779-270-0_19
21 sg:pub.10.1038/nmeth.2603
22 sg:pub.10.1038/nprot.2007.202
23 sg:pub.10.1038/nrg2380
24 sg:pub.10.1038/nsmb.2521
25 sg:pub.10.1038/nsmb.2523
26 https://app.dimensions.ai/details/publication/pub.1078444585
27 https://app.dimensions.ai/details/publication/pub.1078445461
28 https://app.dimensions.ai/details/publication/pub.1082349893
29 https://doi.org/10.1002/pmic.201000616
30 https://doi.org/10.1006/jmbi.1997.1494
31 https://doi.org/10.1006/jmbi.2000.3531
32 https://doi.org/10.1016/0003-2697(85)90586-x
33 https://doi.org/10.1016/0378-1119(92)90588-g
34 https://doi.org/10.1016/0968-0004(94)90280-1
35 https://doi.org/10.1016/j.bcp.2012.03.018
36 https://doi.org/10.1016/j.cell.2010.10.012
37 https://doi.org/10.1016/j.dnarep.2013.04.008
38 https://doi.org/10.1016/j.dnarep.2014.03.021
39 https://doi.org/10.1016/j.molcel.2010.12.006
40 https://doi.org/10.1016/j.tibs.2009.12.003
41 https://doi.org/10.1016/s0076-6879(03)75002-2
42 https://doi.org/10.1016/s1568-7864(03)00118-6
43 https://doi.org/10.1021/ac026359i
44 https://doi.org/10.1021/bi00573a008
45 https://doi.org/10.1021/cb4002014
46 https://doi.org/10.1038/emboj.2012.304
47 https://doi.org/10.1073/pnas.1016574108
48 https://doi.org/10.1073/pnas.79.11.3423
49 https://doi.org/10.1093/bioinformatics/btq054
50 https://doi.org/10.1093/emboj/17.18.5497
51 https://doi.org/10.1093/emboj/cdg206
52 https://doi.org/10.1093/nar/7.3.793
53 https://doi.org/10.1093/nar/gkg761
54 https://doi.org/10.1093/nar/gku174
55 https://doi.org/10.1093/nar/gku474
56 https://doi.org/10.1093/nar/gkv623
57 https://doi.org/10.1111/j.1432-1033.1977.tb11843.x
58 https://doi.org/10.1128/mcb.21.8.2858-2866.2001
59 https://doi.org/10.1128/mcb.23.11.3974-3981.2003
60 https://doi.org/10.1139/o78-119
61 https://doi.org/10.1139/o80-069
62 schema:datePublished 2016-12
63 schema:datePublishedReg 2016-12-01
64 schema:description PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal that PARP3 employs a conserved DNA-binding interface to detect and stably bind DNA breaks and to accumulate at sites of chromosome damage. PARP3 preferentially binds to and is activated by mononucleosomes containing nicked DNA and which target PARP3 trans-ribosylation activity to a single-histone substrate. Although nicks in naked DNA stimulate PARP3 autoribosylation, nicks in mononucleosomes promote the trans-ribosylation of histone H2B specifically at Glu2. These data identify PARP3 as a molecular sensor of nicked nucleosomes and demonstrate, for the first time, the ribosylation of chromatin at a site-specific DNA single-strand break.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree true
68 schema:isPartOf N079cc5fbd4ad40de80f0f2ca1617bacc
69 Nea230926a6d840d4aa5fe227a154237f
70 sg:journal.1043282
71 schema:name PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2
72 schema:pagination 12404
73 schema:productId N09eda31a18284d10bd14e0183a07d29c
74 N2fc592d586904901bab34375810d2e6c
75 N796b5ed4a7fb4a829db4860a98bc7eb0
76 Nb491f8c61d7547a3b419f9ac81491cac
77 Nca985201bf5c4e8a96cf70b5a1f09ed2
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001987728
79 https://doi.org/10.1038/ncomms12404
80 schema:sdDatePublished 2019-04-11T13:20
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N38ce8880239e45788a0002d44e448e5a
83 schema:url http://www.nature.com/articles/ncomms12404
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N079cc5fbd4ad40de80f0f2ca1617bacc schema:issueNumber 1
88 rdf:type schema:PublicationIssue
89 N09eda31a18284d10bd14e0183a07d29c schema:name dimensions_id
90 schema:value pub.1001987728
91 rdf:type schema:PropertyValue
92 N0dac8d21f2914036b43333300a43fa5c rdf:first sg:person.01107312235.45
93 rdf:rest N5bab17c5fba94a89a458b0ef1003e580
94 N170fd75802204f8b8bc240d9fefce93a rdf:first sg:person.01154767332.04
95 rdf:rest rdf:nil
96 N19bd03f45b5a4970a23d20ff53d14bf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Animals
98 rdf:type schema:DefinedTerm
99 N1ebc48759bf54c8ca6f696f342871e91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name DNA Breaks, Single-Stranded
101 rdf:type schema:DefinedTerm
102 N2ab268dc4f2a4b579cbbc630564e79b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Chromosomes
104 rdf:type schema:DefinedTerm
105 N2b303a3f73cf4006aef609d9a28d40f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name DNA
107 rdf:type schema:DefinedTerm
108 N2f9e15926b4c4e57bde5a68d0b15c14a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Chromatin
110 rdf:type schema:DefinedTerm
111 N2fc592d586904901bab34375810d2e6c schema:name readcube_id
112 schema:value 097797eb6be560a59b3f1747748da6a268cb9fccd0e90210d4bf1c50aa9e7821
113 rdf:type schema:PropertyValue
114 N367c51faf8034f0badc463cc6f978b0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Protein Domains
116 rdf:type schema:DefinedTerm
117 N38ce8880239e45788a0002d44e448e5a schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N3b25d32501d24480accd5e1399f47175 rdf:first sg:person.011303000117.64
120 rdf:rest N58929bb39c204400a7bc36feeb1a0f68
121 N47853e4d3eb24844b32dff5576c88b1a rdf:first sg:person.0677761226.51
122 rdf:rest N648da44a36aa4ab28fad68208c39cf3b
123 N4ae474219c52459b8ba0bcfbc705a629 rdf:first sg:person.01175433415.33
124 rdf:rest N0dac8d21f2914036b43333300a43fa5c
125 N4e75952eb90542b3b49438684cd9706d rdf:first sg:person.015607670065.13
126 rdf:rest Ned3e4aa22e714085923d1d372046889c
127 N58929bb39c204400a7bc36feeb1a0f68 rdf:first sg:person.01270302004.29
128 rdf:rest N170fd75802204f8b8bc240d9fefce93a
129 N5bab17c5fba94a89a458b0ef1003e580 rdf:first sg:person.0603273634.50
130 rdf:rest N4e75952eb90542b3b49438684cd9706d
131 N62f9941e93f7492f8ae021e65b5654be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Ribose
133 rdf:type schema:DefinedTerm
134 N648da44a36aa4ab28fad68208c39cf3b rdf:first sg:person.01066624377.88
135 rdf:rest N95371a636a354de3898812c5eb2f67e3
136 N6915104148674d189c77c58f9012cf31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Poly(ADP-ribose) Polymerases
138 rdf:type schema:DefinedTerm
139 N76daa71ef0dc4801a2948e1bf2b6ee28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Histones
141 rdf:type schema:DefinedTerm
142 N796b5ed4a7fb4a829db4860a98bc7eb0 schema:name nlm_unique_id
143 schema:value 101528555
144 rdf:type schema:PropertyValue
145 N8eac747f3b1f48d2b8086713d8a18474 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Humans
147 rdf:type schema:DefinedTerm
148 N928c215d932c46b78462ccff2b47f401 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Models, Molecular
150 rdf:type schema:DefinedTerm
151 N95371a636a354de3898812c5eb2f67e3 rdf:first sg:person.01242763420.61
152 rdf:rest N3b25d32501d24480accd5e1399f47175
153 Nb491f8c61d7547a3b419f9ac81491cac schema:name doi
154 schema:value 10.1038/ncomms12404
155 rdf:type schema:PropertyValue
156 Nb9da5a965ecf4fccb31a6ed9fcb78b33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Cell Line
158 rdf:type schema:DefinedTerm
159 Nc05fca109cfb4008961b42341b926d0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Chickens
161 rdf:type schema:DefinedTerm
162 Nca29217ac37041759432657a990fbc0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Nucleosomes
164 rdf:type schema:DefinedTerm
165 Nca985201bf5c4e8a96cf70b5a1f09ed2 schema:name pubmed_id
166 schema:value 27530147
167 rdf:type schema:PropertyValue
168 Ndf02d69d1cac47ed86ad9bda27095626 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name DNA Repair
170 rdf:type schema:DefinedTerm
171 Ne12ce55684344724816cb6a2153d8b9b rdf:first sg:person.012621766065.52
172 rdf:rest N4ae474219c52459b8ba0bcfbc705a629
173 Ne5fab88064b449fab0a702de81ac873b rdf:first sg:person.0777023614.28
174 rdf:rest Ne12ce55684344724816cb6a2153d8b9b
175 Nea230926a6d840d4aa5fe227a154237f schema:volumeNumber 7
176 rdf:type schema:PublicationVolume
177 Ned3e4aa22e714085923d1d372046889c rdf:first sg:person.0637572111.37
178 rdf:rest N47853e4d3eb24844b32dff5576c88b1a
179 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
180 schema:name Biological Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
183 schema:name Biochemistry and Cell Biology
184 rdf:type schema:DefinedTerm
185 sg:grant.2753715 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12404
186 rdf:type schema:MonetaryGrant
187 sg:grant.2758894 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12404
188 rdf:type schema:MonetaryGrant
189 sg:grant.2761206 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12404
190 rdf:type schema:MonetaryGrant
191 sg:grant.2783585 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12404
192 rdf:type schema:MonetaryGrant
193 sg:grant.3643248 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12404
194 rdf:type schema:MonetaryGrant
195 sg:grant.4456440 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12404
196 rdf:type schema:MonetaryGrant
197 sg:grant.4578921 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms12404
198 rdf:type schema:MonetaryGrant
199 sg:journal.1043282 schema:issn 2041-1723
200 schema:name Nature Communications
201 rdf:type schema:Periodical
202 sg:person.01066624377.88 schema:affiliation https://www.grid.ac/institutes/grid.4701.2
203 schema:familyName Thorne
204 schema:givenName Alan W.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066624377.88
206 rdf:type schema:Person
207 sg:person.01107312235.45 schema:affiliation https://www.grid.ac/institutes/grid.12082.39
208 schema:familyName Rulten
209 schema:givenName Stuart L.
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107312235.45
211 rdf:type schema:Person
212 sg:person.011303000117.64 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
213 schema:familyName Matthews
214 schema:givenName Steve J.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011303000117.64
216 rdf:type schema:Person
217 sg:person.01154767332.04 schema:affiliation https://www.grid.ac/institutes/grid.12082.39
218 schema:familyName Caldecott
219 schema:givenName Keith W.
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154767332.04
221 rdf:type schema:Person
222 sg:person.01175433415.33 schema:affiliation https://www.grid.ac/institutes/grid.12082.39
223 schema:familyName Zeng
224 schema:givenName Zhihong
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175433415.33
226 rdf:type schema:Person
227 sg:person.01242763420.61 schema:affiliation https://www.grid.ac/institutes/grid.12082.39
228 schema:familyName Oliver
229 schema:givenName Antony W.
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242763420.61
231 rdf:type schema:Person
232 sg:person.012621766065.52 schema:affiliation https://www.grid.ac/institutes/grid.12082.39
233 schema:familyName Polo
234 schema:givenName Luis M.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012621766065.52
236 rdf:type schema:Person
237 sg:person.01270302004.29 schema:affiliation https://www.grid.ac/institutes/grid.12082.39
238 schema:familyName Pearl
239 schema:givenName Laurence H.
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270302004.29
241 rdf:type schema:Person
242 sg:person.015607670065.13 schema:affiliation https://www.grid.ac/institutes/grid.12082.39
243 schema:familyName Paomephan
244 schema:givenName Pathompong
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015607670065.13
246 rdf:type schema:Person
247 sg:person.0603273634.50 schema:affiliation https://www.grid.ac/institutes/grid.452295.d
248 schema:familyName Hoch
249 schema:givenName Nicolas C.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603273634.50
251 rdf:type schema:Person
252 sg:person.0637572111.37 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
253 schema:familyName Xu
254 schema:givenName Yingqi
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637572111.37
256 rdf:type schema:Person
257 sg:person.0677761226.51 schema:affiliation https://www.grid.ac/institutes/grid.12082.39
258 schema:familyName Sweet
259 schema:givenName Steve M.
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677761226.51
261 rdf:type schema:Person
262 sg:person.0777023614.28 schema:affiliation https://www.grid.ac/institutes/grid.12082.39
263 schema:familyName Grundy
264 schema:givenName Gabrielle J.
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777023614.28
266 rdf:type schema:Person
267 sg:pub.10.1007/978-1-60327-058-8_14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003564079
268 https://doi.org/10.1007/978-1-60327-058-8_14
269 rdf:type schema:CreativeWork
270 sg:pub.10.1007/978-1-61779-270-0_19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009310953
271 https://doi.org/10.1007/978-1-61779-270-0_19
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nmeth.2603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037744158
274 https://doi.org/10.1038/nmeth.2603
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/nprot.2007.202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009324955
277 https://doi.org/10.1038/nprot.2007.202
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/nrg2380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041270694
280 https://doi.org/10.1038/nrg2380
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nsmb.2521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008847161
283 https://doi.org/10.1038/nsmb.2521
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nsmb.2523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020758140
286 https://doi.org/10.1038/nsmb.2523
287 rdf:type schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1078444585 schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1078445461 schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1082349893 schema:CreativeWork
291 https://doi.org/10.1002/pmic.201000616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046562215
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1006/jmbi.1997.1494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016295630
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1006/jmbi.2000.3531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046351919
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/0003-2697(85)90586-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024431445
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/0378-1119(92)90588-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1032119799
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/0968-0004(94)90280-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047104225
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.bcp.2012.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036963078
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.cell.2010.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024564479
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.dnarep.2013.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022810571
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.dnarep.2014.03.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005445209
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.molcel.2010.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006358626
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.tibs.2009.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019867611
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/s0076-6879(03)75002-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024960320
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s1568-7864(03)00118-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007230713
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1021/ac026359i schema:sameAs https://app.dimensions.ai/details/publication/pub.1032433726
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1021/bi00573a008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055181235
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1021/cb4002014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016693567
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1038/emboj.2012.304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019150020
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1073/pnas.1016574108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033200813
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1073/pnas.79.11.3423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007695233
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1093/bioinformatics/btq054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036379922
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1093/emboj/17.18.5497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023693632
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1093/emboj/cdg206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043892387
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/nar/7.3.793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002927267
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1093/nar/gkg761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031640040
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1093/nar/gku174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014985494
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1093/nar/gku474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001638494
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1093/nar/gkv623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027601855
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1111/j.1432-1033.1977.tb11843.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046690711
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1128/mcb.21.8.2858-2866.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003825698
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1128/mcb.23.11.3974-3981.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025641437
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1139/o78-119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011402605
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1139/o80-069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007189662
356 rdf:type schema:CreativeWork
357 https://www.grid.ac/institutes/grid.12082.39 schema:alternateName University of Sussex
358 schema:name Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK
359 Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK
360 rdf:type schema:Organization
361 https://www.grid.ac/institutes/grid.452295.d schema:alternateName Coordenação de Aperfeicoamento de Pessoal de Nível Superior
362 schema:name CAPES Foundation, Ministry of Education of Brazil, Brasilia/DF 70040-020, Brazil
363 Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK
364 rdf:type schema:Organization
365 https://www.grid.ac/institutes/grid.4701.2 schema:alternateName University of Portsmouth
366 schema:name Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, St Michael’s Building, Portsmouth PO1 2DT, UK
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
369 schema:name Cross-faculty NMR centre, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK
370 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...