TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05-24

AUTHORS

Eun A. Ra, Taeyun A. Lee, Seung Won Kim, Areum Park, Hyun jin Choi, Insook Jang, Sujin Kang, Jae Hee Cheon, Jin Won Cho, Ji Eun Lee, Sungwook Lee, Boyoun Park

ABSTRACT

Autophagy is responsible for the bulk degradation of cytosolic constituents and plays an essential role in the intestinal epithelium by controlling beneficial host-bacterial relationships. Atg5 and Atg7 are thought to be critical for autophagy. However, Atg5- or Atg7-deficient cells still form autophagosomes and autolysosomes, and are capable of removing proteins or bacteria. Here, we report that human TRIM31 (tripartite motif), an intestine-specific protein localized in mitochondria, is essential for promoting lipopolysaccharide-induced Atg5/Atg7-independent autophagy. TRIM31 directly interacts with phosphatidylethanolamine in a palmitoylation-dependent manner, leading to induction of autolysosome formation. Depletion of endogenous TRIM31 significantly increases the number of intestinal epithelial cells containing invasive bacteria. Crohn's disease patients display TRIM31 downregulation. Human cytomegalovirus-infected intestinal cells show a decrease in TRIM31 expression as well as a significant increase in bacterial load, reversible by the introduction of wild-type TRIM31. We provide insight into an alternative autophagy pathway that protects against intestinal pathogenic bacterial infection. More... »

PAGES

11726

References to SciGraph publications

  • 2007-06-07. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls in NATURE
  • 2004-12. The role of autophagy during the early neonatal starvation period in NATURE
  • 2007-05. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis in NATURE GENETICS
  • 1992-07. Shigella flexneri induces apoptosis in infected macrophages in NATURE
  • 2011-01. Autophagy in immunity and inflammation in NATURE
  • 2007-02. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 in NATURE GENETICS
  • 2012-07. The role of neutrophils during intestinal inflammation in MUCOSAL IMMUNOLOGY
  • 2008-02. Autophagy fights disease through cellular self-digestion in NATURE
  • 2000-11. A ubiquitin-like system mediates protein lipidation in NATURE
  • 2006. Paneth Cell α-Defensin Synthesis and Function in ANTIMICROBIAL PEPTIDES AND HUMAN DISEASE
  • 2010-08. Plasma membrane contributes to the formation of pre-autophagosomal structures in NATURE CELL BIOLOGY
  • 2007-07. Unravelling the pathogenesis of inflammatory bowel disease in NATURE
  • 2008-11. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells in NATURE
  • 2009-10. Discovery of Atg5/Atg7-independent alternative macroautophagy in NATURE
  • 2014-02. S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis in CELL DEATH & DISEASE
  • 2010-12. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms11726

    DOI

    http://dx.doi.org/10.1038/ncomms11726

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018376968

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27216961


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