Super-resolution microscopy reveals structural diversity in molecular exchange among peptide amphiphile nanofibres View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05-19

AUTHORS

Ricardo M. P. da Silva, Daan van der Zwaag, Lorenzo Albertazzi, Sungsoo S. Lee, E. W. Meijer, Samuel I. Stupp

ABSTRACT

The dynamic behaviour of supramolecular systems is an important dimension of their potential functions. Here, we report on the use of stochastic optical reconstruction microscopy to study the molecular exchange of peptide amphiphile nanofibres, supramolecular systems known to have important biomedical functions. Solutions of nanofibres labelled with different dyes (Cy3 and Cy5) were mixed, and the distribution of dyes inserting into initially single-colour nanofibres was quantified using correlative image analysis. Our observations are consistent with an exchange mechanism involving monomers or small clusters of molecules inserting randomly into a fibre. Different exchange rates are observed within the same fibre, suggesting that local cohesive structures exist on the basis of β-sheet discontinuous domains. The results reported here show that peptide amphiphile supramolecular systems can be dynamic and that their intermolecular interactions affect exchange patterns. This information can be used to generate useful aggregate morphologies for improved biomedical function. More... »

PAGES

11561

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms11561

DOI

http://dx.doi.org/10.1038/ncomms11561

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011461694

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27194204


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