Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Neil Justin, Ying Zhang, Cataldo Tarricone, Stephen R. Martin, Shuyang Chen, Elizabeth Underwood, Valeria De Marco, Lesley F. Haire, Philip A. Walker, Danny Reinberg, Jon R. Wilson, Steven J. Gamblin

ABSTRACT

Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27me3) via its catalytic SET domain. A missense mutation in the substrate of PRC2, histone H3K27M, is associated with certain pediatric brain cancers and is linked to a global decrease of H3K27me3 in the affected cells thought to be mediated by inhibition of PRC2 activity. We present here the crystal structure of human PRC2 in complex with the inhibitory H3K27M peptide bound to the active site of the SET domain, with the methionine residue located in the pocket that normally accommodates the target lysine residue. The structure and binding studies suggest a mechanism for the oncogenic inhibition of H3K27M. The structure also reveals how binding of repressive marks, like H3K27me3, to the EED subunit of the complex leads to enhancement of the catalytic efficiency of the SET domain and thus the propagation of this repressive histone modification. More... »

PAGES

11316

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms11316

DOI

http://dx.doi.org/10.1038/ncomms11316

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037842189

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27121947


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Catalytic Domain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallography, X-Ray", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enhancer of Zeste Homolog 2 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lysine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polycomb Repressive Complex 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Domains", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Justin", 
        "givenName": "Neil", 
        "id": "sg:person.01231601756.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231601756.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Ying", 
        "id": "sg:person.0715023665.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715023665.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tarricone", 
        "givenName": "Cataldo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Structural Biology Science Technology Platform, Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martin", 
        "givenName": "Stephen R.", 
        "id": "sg:person.010355726752.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010355726752.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Shuyang", 
        "id": "sg:person.01335665611.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335665611.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Underwood", 
        "givenName": "Elizabeth", 
        "id": "sg:person.01114036472.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114036472.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Marco", 
        "givenName": "Valeria", 
        "id": "sg:person.01121214456.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121214456.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK", 
            "Structural Biology Science Technology Platform, Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haire", 
        "givenName": "Lesley F.", 
        "id": "sg:person.0632641351.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632641351.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Structural Biology Science Technology Platform, Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walker", 
        "givenName": "Philip A.", 
        "id": "sg:person.0675423163.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675423163.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University", 
          "id": "https://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "Department of Molecular Pharmacology and Biochemistry, New York University School of Medicine, New York, New York 10016, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reinberg", 
        "givenName": "Danny", 
        "id": "sg:person.0672601630.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672601630.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Jon R.", 
        "id": "sg:person.0726075161.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726075161.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gamblin", 
        "givenName": "Steven J.", 
        "id": "sg:person.014166377647.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014166377647.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature11606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000463489", 
          "https://doi.org/10.1038/nature11606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003047516", 
          "https://doi.org/10.1038/nature12144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn2731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003593041", 
          "https://doi.org/10.1038/nrn2731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn2731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003593041", 
          "https://doi.org/10.1038/nrn2731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004980736", 
          "https://doi.org/10.1038/nrm2763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004980736", 
          "https://doi.org/10.1038/nrm2763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444993011898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005148621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2005-6-8-227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007743076", 
          "https://doi.org/10.1186/gb-2005-6-8-227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009835974", 
          "https://doi.org/10.1038/ncb2065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009835974", 
          "https://doi.org/10.1038/ncb2065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05915", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012257147", 
          "https://doi.org/10.1038/nature05915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889807021206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012753217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0083737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012789906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2011.03.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013778335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014254479", 
          "https://doi.org/10.1038/nature08398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014254479", 
          "https://doi.org/10.1038/nature08398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2008.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014555623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-11-321208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018424481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444998003254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019779527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904019158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444996012255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020405374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909052925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909052925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444994003112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025573949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1315905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026831889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026913602", 
          "https://doi.org/10.1038/nsmb.2679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027386115", 
          "https://doi.org/10.1038/nsmb.2700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.207407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029820125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030505833", 
          "https://doi.org/10.1038/nature09784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030525601", 
          "https://doi.org/10.1038/nsmb.1560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1232245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030869536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032093662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909047337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032162623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909047337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032162623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1225237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034018193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aac4383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034538623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.75.103004.142422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035492837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2014.12.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036060672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.sbi.2010.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036688382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00999-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039815304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja5060934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042243576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043777921", 
          "https://doi.org/10.1038/nature01378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043777921", 
          "https://doi.org/10.1038/nature01378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.217778.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046428161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2014.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047346110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048814086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2012.11.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052138190"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27me3) via its catalytic SET domain. A missense mutation in the substrate of PRC2, histone H3K27M, is associated with certain pediatric brain cancers and is linked to a global decrease of H3K27me3 in the affected cells thought to be mediated by inhibition of PRC2 activity. We present here the crystal structure of human PRC2 in complex with the inhibitory H3K27M peptide bound to the active site of the SET domain, with the methionine residue located in the pocket that normally accommodates the target lysine residue. The structure and binding studies suggest a mechanism for the oncogenic inhibition of H3K27M. The structure also reveals how binding of repressive marks, like H3K27me3, to the EED subunit of the complex leads to enhancement of the catalytic efficiency of the SET domain and thus the propagation of this repressive histone modification.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms11316", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4241592", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2", 
    "pagination": "11316", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b4451e9292512484ecc01a50746df69f6959cbfe023d97e17210f34d8fd6a56e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27121947"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms11316"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037842189"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms11316", 
      "https://app.dimensions.ai/details/publication/pub.1037842189"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54014_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms11316"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms11316'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms11316'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms11316'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms11316'


 

This table displays all metadata directly associated to this object as RDF triples.

343 TRIPLES      21 PREDICATES      84 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms11316 schema:about N1943de60b3f1418fb5ed92f7e711738e
2 N1ec9d999069f4f1abeca69d9e8c4eb60
3 N54ea97f67fc74fe992b0c7fbf4ca685d
4 N61fb2ba2596543139c20481cd59547d3
5 N643c9508544d4958a7fdeea1b54f0a05
6 N6708e7d4d43847798277f8125047440f
7 N6a1cbd5d32e947838b51bc60baa6134c
8 N7d4ad664f228411fae515db6c7da9a87
9 N9eca499b035d4f03b885655f361814e0
10 Na43faac923b94de78eb406b992c4b831
11 Nbe6f22ec37f44d1a97fa03085d204d26
12 Nbeeba802063146ba998a8766efb9f17b
13 Ne90656838d5042da9940440a7fdb7cb7
14 Nee370e4dcae344b8ad9e3b36c5b4e794
15 Nfe180b5227bb430a9cc69244c9ed69bf
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author Nc7388dda07fe4768b78021aa1ffd0d11
19 schema:citation sg:pub.10.1038/nature01378
20 sg:pub.10.1038/nature05915
21 sg:pub.10.1038/nature08398
22 sg:pub.10.1038/nature09784
23 sg:pub.10.1038/nature11606
24 sg:pub.10.1038/nature12144
25 sg:pub.10.1038/ncb2065
26 sg:pub.10.1038/nrm2763
27 sg:pub.10.1038/nrn2731
28 sg:pub.10.1038/nsmb.1560
29 sg:pub.10.1038/nsmb.2679
30 sg:pub.10.1038/nsmb.2700
31 sg:pub.10.1186/gb-2005-6-8-227
32 https://doi.org/10.1016/j.molcel.2011.03.025
33 https://doi.org/10.1016/j.molcel.2012.11.026
34 https://doi.org/10.1016/j.molcel.2014.12.020
35 https://doi.org/10.1016/j.sbi.2010.09.012
36 https://doi.org/10.1016/j.stem.2014.05.006
37 https://doi.org/10.1016/j.str.2008.05.006
38 https://doi.org/10.1016/s0092-8674(02)00999-6
39 https://doi.org/10.1021/ja5060934
40 https://doi.org/10.1074/jbc.m110.207407
41 https://doi.org/10.1093/nar/gkp149
42 https://doi.org/10.1101/gad.1315905
43 https://doi.org/10.1101/gad.217778.113
44 https://doi.org/10.1107/s0021889807021206
45 https://doi.org/10.1107/s0907444904019158
46 https://doi.org/10.1107/s0907444909047337
47 https://doi.org/10.1107/s0907444909052925
48 https://doi.org/10.1107/s0907444993011898
49 https://doi.org/10.1107/s0907444994003112
50 https://doi.org/10.1107/s0907444996012255
51 https://doi.org/10.1107/s0907444998003254
52 https://doi.org/10.1126/science.1225237
53 https://doi.org/10.1126/science.1232245
54 https://doi.org/10.1126/science.aac4383
55 https://doi.org/10.1146/annurev.biochem.75.103004.142422
56 https://doi.org/10.1182/blood-2010-11-321208
57 https://doi.org/10.1371/journal.pone.0083737
58 https://doi.org/10.7554/elife.00005
59 schema:datePublished 2016-12
60 schema:datePublishedReg 2016-12-01
61 schema:description Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27me3) via its catalytic SET domain. A missense mutation in the substrate of PRC2, histone H3K27M, is associated with certain pediatric brain cancers and is linked to a global decrease of H3K27me3 in the affected cells thought to be mediated by inhibition of PRC2 activity. We present here the crystal structure of human PRC2 in complex with the inhibitory H3K27M peptide bound to the active site of the SET domain, with the methionine residue located in the pocket that normally accommodates the target lysine residue. The structure and binding studies suggest a mechanism for the oncogenic inhibition of H3K27M. The structure also reveals how binding of repressive marks, like H3K27me3, to the EED subunit of the complex leads to enhancement of the catalytic efficiency of the SET domain and thus the propagation of this repressive histone modification.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N5a16b22efca14d3ca7eefd8a60e5be67
66 N7fa60357ec124d64a5f3ffc608adafde
67 sg:journal.1043282
68 schema:name Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
69 schema:pagination 11316
70 schema:productId N09b853fdd1b9429092f41757463391fd
71 N15cd70f6055647d981a0fcc0c5705908
72 N94698ee4b2b844d483c23e1ddece00e3
73 Na18d72d0428841a1adfc5c8faf50cd5b
74 Naa62c9dede6e478da282f4b790775234
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037842189
76 https://doi.org/10.1038/ncomms11316
77 schema:sdDatePublished 2019-04-11T12:15
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N966de2e47b2945f78a5c8f439a357dd5
80 schema:url https://www.nature.com/articles/ncomms11316
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N08959fee9ebb4beea85fc0c7b1cf9691 rdf:first sg:person.01335665611.79
85 rdf:rest N13c65b33dbd94765bef13510ef3e4cc9
86 N09b853fdd1b9429092f41757463391fd schema:name nlm_unique_id
87 schema:value 101528555
88 rdf:type schema:PropertyValue
89 N0b3f98092d1540e1b1f1cbba55b7e3f5 rdf:first N11609427b8424ca49d96c27e9701ffc6
90 rdf:rest N4d902193661d42e699356a3eb4225220
91 N11609427b8424ca49d96c27e9701ffc6 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
92 schema:familyName Tarricone
93 schema:givenName Cataldo
94 rdf:type schema:Person
95 N13c65b33dbd94765bef13510ef3e4cc9 rdf:first sg:person.01114036472.18
96 rdf:rest N5a4a862b6fa34e24a47d5811f330a17b
97 N15cd70f6055647d981a0fcc0c5705908 schema:name doi
98 schema:value 10.1038/ncomms11316
99 rdf:type schema:PropertyValue
100 N1943de60b3f1418fb5ed92f7e711738e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Enhancer of Zeste Homolog 2 Protein
102 rdf:type schema:DefinedTerm
103 N1ad20db8173d4f52984b9af94e4ba295 rdf:first sg:person.0632641351.65
104 rdf:rest N63d57a130cdc428b827b01ce17df0f76
105 N1ec9d999069f4f1abeca69d9e8c4eb60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Histones
107 rdf:type schema:DefinedTerm
108 N3a1d6f2591164640b3b7753590c38378 rdf:first sg:person.0672601630.11
109 rdf:rest N3f2fc8ca6c264f19b980fefcf71d536e
110 N3f2fc8ca6c264f19b980fefcf71d536e rdf:first sg:person.0726075161.80
111 rdf:rest Nee1d9437fb464d5da53fa6bfc11a42cb
112 N4d902193661d42e699356a3eb4225220 rdf:first sg:person.010355726752.41
113 rdf:rest N08959fee9ebb4beea85fc0c7b1cf9691
114 N54ea97f67fc74fe992b0c7fbf4ca685d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Polycomb Repressive Complex 2
116 rdf:type schema:DefinedTerm
117 N5a16b22efca14d3ca7eefd8a60e5be67 schema:issueNumber 1
118 rdf:type schema:PublicationIssue
119 N5a4a862b6fa34e24a47d5811f330a17b rdf:first sg:person.01121214456.04
120 rdf:rest N1ad20db8173d4f52984b9af94e4ba295
121 N61fb2ba2596543139c20481cd59547d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Protein Domains
123 rdf:type schema:DefinedTerm
124 N63d57a130cdc428b827b01ce17df0f76 rdf:first sg:person.0675423163.79
125 rdf:rest N3a1d6f2591164640b3b7753590c38378
126 N643c9508544d4958a7fdeea1b54f0a05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Catalytic Domain
128 rdf:type schema:DefinedTerm
129 N6708e7d4d43847798277f8125047440f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Lysine
131 rdf:type schema:DefinedTerm
132 N6a1cbd5d32e947838b51bc60baa6134c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Methylation
134 rdf:type schema:DefinedTerm
135 N7131344f4b2b485bb6db2465b5b72aad rdf:first sg:person.0715023665.91
136 rdf:rest N0b3f98092d1540e1b1f1cbba55b7e3f5
137 N7d4ad664f228411fae515db6c7da9a87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Oncogenes
139 rdf:type schema:DefinedTerm
140 N7fa60357ec124d64a5f3ffc608adafde schema:volumeNumber 7
141 rdf:type schema:PublicationVolume
142 N94698ee4b2b844d483c23e1ddece00e3 schema:name dimensions_id
143 schema:value pub.1037842189
144 rdf:type schema:PropertyValue
145 N966de2e47b2945f78a5c8f439a357dd5 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 N9eca499b035d4f03b885655f361814e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Models, Molecular
149 rdf:type schema:DefinedTerm
150 Na18d72d0428841a1adfc5c8faf50cd5b schema:name pubmed_id
151 schema:value 27121947
152 rdf:type schema:PropertyValue
153 Na43faac923b94de78eb406b992c4b831 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Brain Neoplasms
155 rdf:type schema:DefinedTerm
156 Naa62c9dede6e478da282f4b790775234 schema:name readcube_id
157 schema:value b4451e9292512484ecc01a50746df69f6959cbfe023d97e17210f34d8fd6a56e
158 rdf:type schema:PropertyValue
159 Nbe6f22ec37f44d1a97fa03085d204d26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Protein Binding
161 rdf:type schema:DefinedTerm
162 Nbeeba802063146ba998a8766efb9f17b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Carcinogenesis
164 rdf:type schema:DefinedTerm
165 Nc7388dda07fe4768b78021aa1ffd0d11 rdf:first sg:person.01231601756.06
166 rdf:rest N7131344f4b2b485bb6db2465b5b72aad
167 Ne90656838d5042da9940440a7fdb7cb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Mutation
169 rdf:type schema:DefinedTerm
170 Nee1d9437fb464d5da53fa6bfc11a42cb rdf:first sg:person.014166377647.07
171 rdf:rest rdf:nil
172 Nee370e4dcae344b8ad9e3b36c5b4e794 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Humans
174 rdf:type schema:DefinedTerm
175 Nfe180b5227bb430a9cc69244c9ed69bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Crystallography, X-Ray
177 rdf:type schema:DefinedTerm
178 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
179 schema:name Biological Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
182 schema:name Biochemistry and Cell Biology
183 rdf:type schema:DefinedTerm
184 sg:grant.4241592 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms11316
185 rdf:type schema:MonetaryGrant
186 sg:journal.1043282 schema:issn 2041-1723
187 schema:name Nature Communications
188 rdf:type schema:Periodical
189 sg:person.010355726752.41 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
190 schema:familyName Martin
191 schema:givenName Stephen R.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010355726752.41
193 rdf:type schema:Person
194 sg:person.01114036472.18 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
195 schema:familyName Underwood
196 schema:givenName Elizabeth
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114036472.18
198 rdf:type schema:Person
199 sg:person.01121214456.04 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
200 schema:familyName De Marco
201 schema:givenName Valeria
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121214456.04
203 rdf:type schema:Person
204 sg:person.01231601756.06 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
205 schema:familyName Justin
206 schema:givenName Neil
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231601756.06
208 rdf:type schema:Person
209 sg:person.01335665611.79 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
210 schema:familyName Chen
211 schema:givenName Shuyang
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335665611.79
213 rdf:type schema:Person
214 sg:person.014166377647.07 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
215 schema:familyName Gamblin
216 schema:givenName Steven J.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014166377647.07
218 rdf:type schema:Person
219 sg:person.0632641351.65 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
220 schema:familyName Haire
221 schema:givenName Lesley F.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632641351.65
223 rdf:type schema:Person
224 sg:person.0672601630.11 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
225 schema:familyName Reinberg
226 schema:givenName Danny
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672601630.11
228 rdf:type schema:Person
229 sg:person.0675423163.79 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
230 schema:familyName Walker
231 schema:givenName Philip A.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675423163.79
233 rdf:type schema:Person
234 sg:person.0715023665.91 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
235 schema:familyName Zhang
236 schema:givenName Ying
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715023665.91
238 rdf:type schema:Person
239 sg:person.0726075161.80 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
240 schema:familyName Wilson
241 schema:givenName Jon R.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726075161.80
243 rdf:type schema:Person
244 sg:pub.10.1038/nature01378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043777921
245 https://doi.org/10.1038/nature01378
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/nature05915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012257147
248 https://doi.org/10.1038/nature05915
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nature08398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014254479
251 https://doi.org/10.1038/nature08398
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nature09784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030505833
254 https://doi.org/10.1038/nature09784
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/nature11606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000463489
257 https://doi.org/10.1038/nature11606
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/nature12144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003047516
260 https://doi.org/10.1038/nature12144
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/ncb2065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009835974
263 https://doi.org/10.1038/ncb2065
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nrm2763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004980736
266 https://doi.org/10.1038/nrm2763
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/nrn2731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003593041
269 https://doi.org/10.1038/nrn2731
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/nsmb.1560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030525601
272 https://doi.org/10.1038/nsmb.1560
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/nsmb.2679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026913602
275 https://doi.org/10.1038/nsmb.2679
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/nsmb.2700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027386115
278 https://doi.org/10.1038/nsmb.2700
279 rdf:type schema:CreativeWork
280 sg:pub.10.1186/gb-2005-6-8-227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007743076
281 https://doi.org/10.1186/gb-2005-6-8-227
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.molcel.2011.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013778335
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.molcel.2012.11.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052138190
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.molcel.2014.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036060672
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.sbi.2010.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036688382
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.stem.2014.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047346110
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.str.2008.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014555623
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0092-8674(02)00999-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039815304
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1021/ja5060934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042243576
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1074/jbc.m110.207407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029820125
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1093/nar/gkp149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048814086
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1101/gad.1315905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026831889
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1101/gad.217778.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046428161
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1107/s0021889807021206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012753217
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1107/s0907444904019158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281098
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1107/s0907444909047337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032162623
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1107/s0907444909052925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020777046
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1107/s0907444993011898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005148621
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1107/s0907444994003112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025573949
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1107/s0907444996012255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020405374
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1107/s0907444998003254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019779527
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1126/science.1225237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034018193
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1126/science.1232245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030869536
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1126/science.aac4383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034538623
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1146/annurev.biochem.75.103004.142422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035492837
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1182/blood-2010-11-321208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018424481
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1371/journal.pone.0083737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012789906
334 rdf:type schema:CreativeWork
335 https://doi.org/10.7554/elife.00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032093662
336 rdf:type schema:CreativeWork
337 https://www.grid.ac/institutes/grid.137628.9 schema:alternateName New York University
338 schema:name Department of Molecular Pharmacology and Biochemistry, New York University School of Medicine, New York, New York 10016, USA
339 rdf:type schema:Organization
340 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
341 schema:name Structural Biology Science Technology Platform, Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK
342 The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK
343 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...