Major bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-02-03

AUTHORS

David Burstein, Christine L. Sun, Christopher T. Brown, Itai Sharon, Karthik Anantharaman, Alexander J. Probst, Brian C. Thomas, Jillian F. Banfield

ABSTRACT

Current understanding of microorganism-virus interactions, which shape the evolution and functioning of Earth's ecosystems, is based primarily on cultivated organisms. Here we investigate thousands of viral and microbial genomes recovered using a cultivation-independent approach to study the frequency, variety and taxonomic distribution of viral defence mechanisms. CRISPR-Cas systems that confer microorganisms with immunity to viruses are present in only 10% of 1,724 sampled microorganisms, compared with previous reports of 40% occurrence in bacteria and 81% in archaea. We attribute this large difference to the lack of CRISPR-Cas systems across major bacterial lineages that have no cultivated representatives. We correlate absence of CRISPR-Cas with lack of nucleotide biosynthesis capacity and a symbiotic lifestyle. Restriction systems are well represented in these lineages and might provide both non-specific viral defence and access to nucleotides. More... »

PAGES

10613

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms10613

DOI

http://dx.doi.org/10.1038/ncomms10613

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022975138

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26837824


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