Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-01-12

AUTHORS

Victor Laurent, Adrien Guérard, Catherine Mazerolles, Sophie Le Gonidec, Aurélie Toulet, Laurence Nieto, Falek Zaidi, Bilal Majed, David Garandeau, Youri Socrier, Muriel Golzio, Thomas Cadoudal, Karima Chaoui, Cedric Dray, Bernard Monsarrat, Odile Schiltz, Yuan Yuan Wang, Bettina Couderc, Philippe Valet, Bernard Malavaud, Catherine Muller

ABSTRACT

Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this event is strongly promoted by obesity. This process is dependent on the secretion of the chemokine CCL7 by adipocytes, which diffuses from PPAT to the peripheral zone of the prostate, stimulating the migration of CCR3 expressing tumour cells. In obesity, higher secretion of CCL7 by adipocytes facilitates extraprostatic extension. The observed increase in migration associated with obesity is totally abrogated when the CCR3/CCL7 axis is inhibited. In human prostate cancer tumours, expression of the CCR3 receptor is associated with the occurrence of aggressive disease with extended local dissemination and a higher risk of biochemical recurrence, highlighting the potential benefit of CCR3 antagonists in the treatment of prostate cancer. More... »

PAGES

10230

References to SciGraph publications

  • 2011-01. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 3: extraprostatic extension, lymphovascular invasion and locally advanced disease in MODERN PATHOLOGY
  • 2007-01. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment in NATURE REVIEWS IMMUNOLOGY
  • 2000-05. Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice in INTERNATIONAL JOURNAL OF OBESITY
  • 2011-02. Adipokines in inflammation and metabolic disease in NATURE REVIEWS IMMUNOLOGY
  • 2004-03. Gleason grading and prognostic factors in carcinoma of the prostate in MODERN PATHOLOGY
  • 2000-06. Hyperleptinemia is more closely associated with adipose cell hypertrophy than with adipose tissue hyperplasia in INTERNATIONAL JOURNAL OF OBESITY
  • 2002-02. Chemokine receptors: multifaceted therapeutic targets in NATURE REVIEWS IMMUNOLOGY
  • 2014-07. CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice in DIABETOLOGIA
  • 2013-12. Obese men have more advanced and more aggressive prostate cancer at time of surgery than non-obese men after adjusting for screening PSA level and age: results from two independent nested case–control studies in PROSTATE CANCER AND PROSTATIC DISEASES
  • 2004-07. Cancer and the chemokine network in NATURE REVIEWS CANCER
  • 2009-07. Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells in ONCOGENE
  • 2008-12. Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2012-12. Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2011-11. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms10230

    DOI

    http://dx.doi.org/10.1038/ncomms10230

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023788104

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26756352


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

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    N-Triples is a line-based linked data format ideal for batch operations.

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