Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Jean Albrengues, Thomas Bertero, Eloise Grasset, Stephanie Bonan, Majdi Maiel, Isabelle Bourget, Claude Philippe, Cecilia Herraiz Serrano, Samia Benamar, Olivier Croce, Victoria Sanz-Moreno, Guerrino Meneguzzi, Chloe C. Feral, Gael Cristofari, Cedric Gaggioli

ABSTRACT

Carcinoma-associated fibroblasts (CAF) mediate the onset of a proinvasive tumour microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a proinvasive phenotype, which promotes extracellular matrix remodelling and collective invasion of cancer cells. Here we unveil that exposure to LIF initiates an epigenetic switch leading to the constitutive activation of JAK1/STAT3 signalling, which results in sustained proinvasive activity of CAF. Mechanistically, p300-histone acetyltransferase acetylates STAT3, which, in turn, upregulates and activates the DNMT3b DNA methyltransferase. DNMT3b methylates CpG sites of the SHP-1 phosphatase promoter, which abrogates SHP-1 expression, and results in constitutive phosphorylation of JAK1. Sustained JAK1/STAT3 signalling is maintained by DNA methyltransferase DNMT1. Consistently, in human lung and head and neck carcinomas, STAT3 acetylation and phosphorylation are inversely correlated with SHP-1 expression. Combined inhibition of DNMT activities and JAK signalling, in vitro and in vivo, results in long-term reversion of CAF-associated proinvasive activity and restoration of the wild-type fibroblast phenotype. More... »

PAGES

10204

References to SciGraph publications

  • 2009-01. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours in NATURE
  • 2004-06. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting in NATURE
  • 2004-05. p300/CBP and cancer in ONCOGENE
  • 2006-05. Fibroblasts in cancer in NATURE REVIEWS CANCER
  • 2002-08. 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy in ONCOGENE
  • 2009-11. STATs in cancer inflammation and immunity: a leading role for STAT3 in NATURE REVIEWS CANCER
  • 2012-07. Mechanisms of fibrosis: therapeutic translation for fibrotic disease in NATURE MEDICINE
  • 2010-05. Methylation determines fibroblast activation and fibrogenesis in the kidney in NATURE MEDICINE
  • 2015-01. Asporin activates coordinated invasion of scirrhous gastric cancer and cancer-associated fibroblasts in ONCOGENE
  • 2014-10. A reciprocal role of prostate cancer on stromal DNA damage in ONCOGENE
  • 2007-12. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells in NATURE CELL BIOLOGY
  • 2000-11. Janus kinases: components of multiple signaling pathways in ONCOGENE
  • 2013-06. Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts in NATURE CELL BIOLOGY
  • 2013. Analysis of Collective Invasion of Carcinoma Cells in a 3D Organotypic Model in MOLECULAR DERMATOLOGY
  • 2008-03. Using principle component analysis to compare genetic diversity across polyploidy levels within plant complexes: an example from British Restharrows (Ononis spinosa and Ononis repens) in HEREDITY
  • 1999-07. STAT Signaling in the Pathogenesis and Treatment of Cancer in MOLECULAR MEDICINE
  • 2012-12. Global analysis of DNA methylation in early-stage liver fibrosis in BMC MEDICAL GENOMICS
  • 2000-05. STATs in oncogenesis in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms10204

    DOI

    http://dx.doi.org/10.1038/ncomms10204

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014338536

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26667266


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