Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Johan Siewiera, Jordi Gouilly, Hocine-Rachid Hocine, Géraldine Cartron, Claude Levy, Reem Al-Daccak, Nabila Jabrane-Ferrat

ABSTRACT

The natural cytotoxicity receptors NKp46/NCR1, NKp44/NCR2 and NKp30/NCR3 are critical for natural killer (NK) cell functions. Their genes are transcribed into several splice variants whose physiological relevance is not yet fully understood. Here we report that decidua basalis NK (dNK) cells of the pregnant uterine mucosa and peripheral blood NK (pNK) cells, two functionally distinct subsets of the physiological NK cell pool, display differential expression of NKp30/NCR3 and NKp44/NCR2 splice variants. The presence of cytokines that are enriched within the decidual microenvironment is sufficient to convert the splice variant profile of pNK cells into one similar to that of dNK cells. This switch is associated with decreased cytotoxic function and major adaptations to the secretome, hallmarks of the decidual phenotype. Thus, NKp30/NCR3 and NKp44/NCR2 splice variants delineate functionally distinct NK cell subsets. To our knowledge, this is the first conclusive evidence underlining the physiological importance of NCR splice variants. More... »

PAGES

10183

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms10183

DOI

http://dx.doi.org/10.1038/ncomms10183

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029701873

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26666685


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