Ontology type: schema:ScholarlyArticle Open Access: True
2015-12
AUTHORSJohan Siewiera, Jordi Gouilly, Hocine-Rachid Hocine, Géraldine Cartron, Claude Levy, Reem Al-Daccak, Nabila Jabrane-Ferrat
ABSTRACTThe natural cytotoxicity receptors NKp46/NCR1, NKp44/NCR2 and NKp30/NCR3 are critical for natural killer (NK) cell functions. Their genes are transcribed into several splice variants whose physiological relevance is not yet fully understood. Here we report that decidua basalis NK (dNK) cells of the pregnant uterine mucosa and peripheral blood NK (pNK) cells, two functionally distinct subsets of the physiological NK cell pool, display differential expression of NKp30/NCR3 and NKp44/NCR2 splice variants. The presence of cytokines that are enriched within the decidual microenvironment is sufficient to convert the splice variant profile of pNK cells into one similar to that of dNK cells. This switch is associated with decreased cytotoxic function and major adaptations to the secretome, hallmarks of the decidual phenotype. Thus, NKp30/NCR3 and NKp44/NCR2 splice variants delineate functionally distinct NK cell subsets. To our knowledge, this is the first conclusive evidence underlining the physiological importance of NCR splice variants. More... »
PAGES10183
http://scigraph.springernature.com/pub.10.1038/ncomms10183
DOIhttp://dx.doi.org/10.1038/ncomms10183
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26666685
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms10183'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms10183'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms10183'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms10183'
This table displays all metadata directly associated to this object as RDF triples.
343 TRIPLES
21 PREDICATES
97 URIs
33 LITERALS
21 BLANK NODES