Entropy rectifies the Brownian steps of kinesin View Full Text


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Article Info

DATE

2005-10-09

AUTHORS

Yuichi Taniguchi, Masayoshi Nishiyama, Yoshiharu Ishii, Toshio Yanagida

ABSTRACT

Kinesin is a stepping motor that successively produces forward and backward 8-nm steps along microtubules. Under physiological conditions, the steps powering kinesin's motility are biased in one direction and drive various biological motile processes. The physical mechanism underlying the unidirectional bias of the kinesin steps is not fully understood. Here we explored the mechanical kinetics and thermodynamics of forward and backward kinesin steps by analyzing their temperature and load dependence. Results show that the frequency asymmetry between forward and backward steps is produced by entropy. Furthermore, the magnitude of the entropic asymmetry is 6 kBT, more than three times greater than expected from a current model, in which a mechanical conformational change within the kinesin molecular structure directly biases the kinesin steps forward. We propose that the stepping direction of kinesin is preferably caused by an entropy asymmetry resulting from the compatibility between the kinesin and microtubule interaction based on their polar structures. More... »

PAGES

342-347

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio741

DOI

http://dx.doi.org/10.1038/nchembio741

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043786584

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16408074


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