Cyclization in concert View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12

AUTHORS

Marco W Fraaije, Andrea Mattevi

ABSTRACT

The berberine bridge enzyme catalyzes the crucial step in the biosynthesis of an important class of alkaloids through a reaction that cannot be carried out using conventional organic chemistry tools. Characterization of the enzyme demonstrates a concerted mechanism that couples two distinct chemical steps—oxidation and proton abstraction—affecting two separate groups of the substrate. More... »

PAGES

719-721

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio1208-719

DOI

http://dx.doi.org/10.1038/nchembio1208-719

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027648595

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19008880


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