Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-08-07

AUTHORS

Seung Seo Lee, Sung You Hong, James C Errey, Atsushi Izumi, Gideon J Davies, Benjamin G Davis

ABSTRACT

The combination of several biochemical analyses, including determination of kinetic isotope effects and linear free energy relationships, offer the first detailed insights into a natural SNi-like reaction mechanism and provide compelling evidence for a frontal nucleophilic substitution in a retaining glycosyltransferase.

PAGES

631-638

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio.628

DOI

http://dx.doi.org/10.1038/nchembio.628

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024449038

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21822275


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