Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04-17

AUTHORS

Bailong Xiao, Bertrand Coste, Jayanti Mathur, Ardem Patapoutian

ABSTRACT

Intracellular Ca(2+) is essential for diverse cellular functions. Ca(2+) entry into many cell types including immune cells is triggered by depleting endoplasmic reticulum (ER) Ca(2+), a process termed store-operated Ca(2+) entry (SOCE). STIM1 is an ER Ca(2+) sensor. Upon Ca(2+) store depletion, STIM1 clusters at ER-plasma membrane junctions where it interacts with and gates Ca(2+)-permeable Orai1 ion channels. Here we show that STIM1 is also activated by temperature. Heating cells caused clustering of STIM1 at temperatures above 35 °C without depleting Ca(2+) stores and led to Orai1-mediated Ca(2+) influx as a heat off-response (response after cooling). Notably, the functional coupling of STIM1 and Orai1 is prevented at high temperatures, potentially explaining the heat off-response. Additionally, physiologically relevant temperature shifts modulate STIM1-dependent gene expression in Jurkat T cells. Therefore, temperature is an important regulator of STIM1 function. More... »

PAGES

351-358

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio.558

DOI

http://dx.doi.org/10.1038/nchembio.558

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051925252

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21499266


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