The role of physiological heterogeneity in microbial population behavior View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-09-17

AUTHORS

Mary E Lidstrom, Michael C Konopka

ABSTRACT

As the ability to analyze individual cells in microbial populations expands, it is becoming apparent that isogenic microbial populations contain substantial cell-to-cell differences in physiological parameters such as growth rate, resistance to stress and regulatory circuit output. Subpopulations exist that are manyfold different in these parameters from the population average, and these differences arise by stochastic processes. Such differences can dramatically affect the response of cells to perturbations, especially stress, which in turn dictates overall population response. Defining the role of cell-to-cell heterogeneity in population behavior is important for understanding population-based research problems, including those involving infecting populations, normal flora and bacterial populations in water and soils. Emerging technological breakthroughs are poised to transform single-cell analysis and are critical for the next phase of insights into physiological heterogeneity in the near future. These include technologies for multiparameter analysis of live cells, with downstream processing and analysis. More... »

PAGES

705

References to SciGraph publications

  • 2006-03. Stochastic protein expression in individual cells at the single molecule level in NATURE
  • 2008-07. Real-time detection of actively metabolizing microbes by redox sensing as applied to methylotroph populations in Lake Washington in THE ISME JOURNAL
  • 2006-06. Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise in NATURE
  • 2005-09. Contributions of low molecule number and chromosomal positioning to stochastic gene expression in NATURE GENETICS
  • 2005-09. Regulated cell-to-cell variation in a cell-fate decision system in NATURE
  • 2010-05. Single-cell analysis and isolation for microbiology and biotechnology: methods and applications in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2008-12. Genetic noise control via protein oligomerization in BMC SYSTEMS BIOLOGY
  • 2000-08. ClpP/ClpX-mediated degradation of the bacteriophage λ O protein and regulation of λ phage and λ plasmid replication in ARCHIVES OF MICROBIOLOGY
  • 2009-11. Emergent bistability by a growth-modulating positive feedback circuit in NATURE CHEMICAL BIOLOGY
  • 2009-06. Force probing surfaces of living cells to molecular resolution in NATURE CHEMICAL BIOLOGY
  • 2009-05. Using movies to analyse gene circuit dynamics in single cells in NATURE REVIEWS MICROBIOLOGY
  • 2010-11. Analytical techniques for single-cell metabolomics: state of the art and trends in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2009-01. Determining biological noise via single cell analysis in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2005-06. Stochasticity in gene expression: from theories to phenotypes in NATURE REVIEWS GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nchembio.436

    DOI

    http://dx.doi.org/10.1038/nchembio.436

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003940702

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20852608


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