Activity-based probes for functional interrogation of retaining β-glucuronidases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06-05

AUTHORS

Liang Wu, Jianbing Jiang, Yi Jin, Wouter W Kallemeijn, Chi-Lin Kuo, Marta Artola, Wei Dai, Cas van Elk, Marco van Eijk, Gijsbert A van der Marel, Jeroen D C Codée, Bogdan I Florea, Johannes M F G Aerts, Herman S Overkleeft, Gideon J Davies

ABSTRACT

Synthesis and application of activity-based probes based on cyclophellitol enabled the cellular profiling of β-glucuronidase activity and revealed an unexpected feature of endo-acting heparanase processing.

PAGES

867-873

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio.2395

DOI

http://dx.doi.org/10.1038/nchembio.2395

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085863335

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28581485


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