Structural basis of nonribosomal peptide macrocyclization in fungi View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Jinru Zhang, Nicholas Liu, Ralph A Cacho, Zhou Gong, Zhu Liu, Wenming Qin, Chun Tang, Yi Tang, Jiahai Zhou

ABSTRACT

Nonribosomal peptide synthetases (NRPSs) in fungi biosynthesize important pharmaceutical compounds, including penicillin, cyclosporine and echinocandin. To understand the fungal strategy of forging the macrocyclic peptide linkage, we determined the crystal structures of the terminal condensation-like (CT) domain and the holo thiolation (T)-CT complex of Penicillium aethiopicum TqaA. The first, to our knowledge, structural depiction of the terminal module in a fungal NRPS provides a molecular blueprint for generating new macrocyclic peptide natural products. More... »

PAGES

1001-1003

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio.2202

DOI

http://dx.doi.org/10.1038/nchembio.2202

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047650784

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27748753


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