Mechanisms, biology and inhibitors of deubiquitinating enzymes View Full Text


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Article Info

DATE

2007-11

AUTHORS

Kerry Routenberg Love, André Catic, Christian Schlieker, Hidde L Ploegh

ABSTRACT

The addition of ubiquitin (Ub) and ubiquitin-like (Ubl) modifiers to proteins serves to modulate function and is a key step in protein degradation, epigenetic modification and intracellular localization. Deubiquitinating enzymes and Ubl-specific proteases, the proteins responsible for the removal of Ub and Ubls, act as an additional level of control over the ubiquitin-proteasome system. Their conservation and widespread occurrence in eukaryotes, prokaryotes and viruses shows that these proteases constitute an essential class of enzymes. Here, we discuss how chemical tools, including activity-based probes and suicide inhibitors, have enabled (i) discovery of deubiquitinating enzymes, (ii) their functional profiling, crystallographic characterization and mechanistic classification and (iii) development of molecules for therapeutic purposes. More... »

PAGES

697

References to SciGraph publications

  • 2003-08. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB in NATURE
  • 2004-03. Ubiquitin and breast cancer in ONCOGENE
  • 1998-04. An oncogenic fusion product of the phosphatidylinositol 3-kinase p85β subunit and HUMORF8, a putative deubiquitinating enzyme in ONCOGENE
  • 2003-08. CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members in NATURE
  • 2003-08. The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination in NATURE
  • 2005-08. Ubiquitin-binding domains in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2004-11. Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity in NATURE GENETICS
  • 2000-06. Identification of the familial cylindromatosis tumour-suppressor gene in NATURE GENETICS
  • 2002-11. Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease in NATURE GENETICS
  • 2007-02-21. Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue in NATURE CELL BIOLOGY
  • 2006-07. Drug discovery in the ubiquitin–proteasome system in NATURE REVIEWS DRUG DISCOVERY
  • 2006. Parkin and defective ubiquitination in Parkinson’s disease in PARKINSON’S DISEASE AND RELATED DISORDERS
  • 2007-04. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities in NATURE
  • 2006-03. The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like β-grasp domains in GENOME BIOLOGY
  • 2006-04. Regulation of monoubiquitinated PCNA by DUB autocleavage in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nchembio.2007.43

    DOI

    http://dx.doi.org/10.1038/nchembio.2007.43

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031146340

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17948018


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