Telomere length, stem cells and aging View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

Maria A Blasco

ABSTRACT

Telomere shortening occurs concomitant with organismal aging, and it is accelerated in the context of human diseases associated with mutations in telomerase, such as some cases of dyskeratosis congenita, idiopathic pulmonary fibrosis and aplastic anemia. People with these diseases, as well as Terc-deficient mice, show decreased lifespan coincidental with a premature loss of tissue renewal, which suggests that telomerase is rate-limiting for tissue homeostasis and organismal survival. These findings have gained special relevance as they suggest that telomerase activity and telomere length can directly affect the ability of stem cells to regenerate tissues. If this is true, stem cell dysfunction provoked by telomere shortening may be one of the mechanisms responsible for organismal aging in both humans and mice. Here, we will review the current evidence linking telomere shortening to aging and stem cell dysfunction. More... »

PAGES

640-649

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nchembio.2007.38

    DOI

    http://dx.doi.org/10.1038/nchembio.2007.38

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030185521

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17876321


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