Dark chemical matter as a promising starting point for drug lead discovery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12

AUTHORS

Anne Mai Wassermann, Eugen Lounkine, Dominic Hoepfner, Gaelle Le Goff, Frederick J King, Christian Studer, John M Peltier, Melissa L Grippo, Vivian Prindle, Jianshi Tao, Ansgar Schuffenhauer, Iain M Wallace, Shanni Chen, Philipp Krastel, Amanda Cobos-Correa, Christian N Parker, John W Davies, Meir Glick

ABSTRACT

High-throughput screening (HTS) is an integral part of early drug discovery. Herein, we focused on those small molecules in a screening collection that have never shown biological activity despite having been exhaustively tested in HTS assays. These compounds are referred to as 'dark chemical matter' (DCM). We quantified DCM, validated it in quality control experiments, described its physicochemical properties and mapped it into chemical space. Through analysis of prospective reporter-gene assay, gene expression and yeast chemogenomics experiments, we evaluated the potential of DCM to show biological activity in future screens. We demonstrated that, despite the apparent lack of activity, occasionally these compounds can result in potent hits with unique activity and clean safety profiles, which makes them valuable starting points for lead optimization efforts. Among the identified DCM hits was a new antifungal chemotype with strong activity against the pathogen Cryptococcus neoformans but little activity at targets relevant to human safety. More... »

PAGES

958-966

References to SciGraph publications

  • 2011-03. Probing the links between in vitro potency, ADMET and physicochemical parameters in NATURE REVIEWS DRUG DISCOVERY
  • 2012-12. InChIKey collision resistance: an experimental testing in JOURNAL OF CHEMINFORMATICS
  • 2009-07. A crowdsourcing evaluation of the NIH chemical probes in NATURE CHEMICAL BIOLOGY
  • 2011-03. Impact of high-throughput screening in biomedical research in NATURE REVIEWS DRUG DISCOVERY
  • 2012-12. Determination of minimal transcriptional signatures of compounds for target prediction in EURASIP JOURNAL ON BIOINFORMATICS AND SYSTEMS BIOLOGY
  • 2004-12. Chemical space and biology in NATURE
  • 2012-02. Quantifying the chemical beauty of drugs in NATURE CHEMISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nchembio.1936

    DOI

    http://dx.doi.org/10.1038/nchembio.1936

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039897559

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26479441


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antifungal Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cryptococcus neoformans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Discovery", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "High-Throughput Screening Assays", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microbial Sensitivity Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Structure", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Structure-Activity Relationship", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Novartis (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418424.f", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wassermann", 
            "givenName": "Anne Mai", 
            "id": "sg:person.01024677500.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024677500.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418424.f", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lounkine", 
            "givenName": "Eugen", 
            "id": "sg:person.01260774030.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260774030.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (Switzerland)", 
              "id": "https://www.grid.ac/institutes/grid.419481.1", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Basel, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hoepfner", 
            "givenName": "Dominic", 
            "id": "sg:person.0671724111.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671724111.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418424.f", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Le Goff", 
            "givenName": "Gaelle", 
            "id": "sg:person.01213323641.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213323641.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genomics Institute of the Novartis Research Foundation", 
              "id": "https://www.grid.ac/institutes/grid.418185.1", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA.", 
                "The Genomics Institute of the Novartis Research Foundation, San Diego, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "King", 
            "givenName": "Frederick J", 
            "id": "sg:person.01304235105.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304235105.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (Switzerland)", 
              "id": "https://www.grid.ac/institutes/grid.419481.1", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Basel, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Studer", 
            "givenName": "Christian", 
            "id": "sg:person.0705267411.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705267411.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418424.f", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peltier", 
            "givenName": "John M", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418424.f", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grippo", 
            "givenName": "Melissa L", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genomics Institute of the Novartis Research Foundation", 
              "id": "https://www.grid.ac/institutes/grid.418185.1", 
              "name": [
                "The Genomics Institute of the Novartis Research Foundation, San Diego, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Prindle", 
            "givenName": "Vivian", 
            "id": "sg:person.0725154362.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725154362.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genomics Institute of the Novartis Research Foundation", 
              "id": "https://www.grid.ac/institutes/grid.418185.1", 
              "name": [
                "The Genomics Institute of the Novartis Research Foundation, San Diego, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tao", 
            "givenName": "Jianshi", 
            "id": "sg:person.01236551443.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236551443.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (Switzerland)", 
              "id": "https://www.grid.ac/institutes/grid.419481.1", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Basel, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schuffenhauer", 
            "givenName": "Ansgar", 
            "id": "sg:person.01175336460.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175336460.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418424.f", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wallace", 
            "givenName": "Iain M", 
            "id": "sg:person.01273152475.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273152475.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418424.f", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Shanni", 
            "id": "sg:person.0612327172.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612327172.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (Switzerland)", 
              "id": "https://www.grid.ac/institutes/grid.419481.1", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Basel, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Krastel", 
            "givenName": "Philipp", 
            "id": "sg:person.01025163525.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025163525.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (Switzerland)", 
              "id": "https://www.grid.ac/institutes/grid.419481.1", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Basel, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cobos-Correa", 
            "givenName": "Amanda", 
            "id": "sg:person.01140374426.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140374426.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (Switzerland)", 
              "id": "https://www.grid.ac/institutes/grid.419481.1", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Basel, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parker", 
            "givenName": "Christian N", 
            "id": "sg:person.01032066755.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032066755.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418424.f", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Davies", 
            "givenName": "John W", 
            "id": "sg:person.01326332541.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326332541.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418424.f", 
              "name": [
                "Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Glick", 
            "givenName": "Meir", 
            "id": "sg:person.0602726441.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602726441.08"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.1410933111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001570523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4155/fmc.14.72", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002746588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002983472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gku1214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006546975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(00)00129-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006677292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.micres.2013.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006712670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchem.1243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009671604", 
              "https://doi.org/10.1038/nchem.1243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1687-4153-2012-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009797683", 
              "https://doi.org/10.1186/1687-4153-2012-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2770017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011177123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2770017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011177123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm9602928", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011887615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm9602928", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011887615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014842119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cmdc.200700036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015973334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ci100050t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016898407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ci100050t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016898407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio0709-441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016974153", 
              "https://doi.org/10.1038/nchembio0709-441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio0709-441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016974153", 
              "https://doi.org/10.1038/nchembio0709-441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm401120g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019936584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1250217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020589828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0061(199611)12:14<1421::aid-yea38>3.0.co;2-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027264470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0061(199611)12:14<1421::aid-yea38>3.0.co;2-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027264470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cmdc.201402129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032948586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1060762", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033500451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cbpa.2004.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033891139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.10-170811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035630875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035797641", 
              "https://doi.org/10.1038/nrd3367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1758-2946-4-39", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037214563", 
              "https://doi.org/10.1186/1758-2946-4-39"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040832969", 
              "https://doi.org/10.1038/nature03192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040832969", 
              "https://doi.org/10.1038/nature03192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041527430", 
              "https://doi.org/10.1038/nrd3368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.drudis.2013.02.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043656376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr1132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043796486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4155/fmc.09.51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047359531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ci050352v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047984405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ci050352v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047984405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1145/364520.364540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053610335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jala.2009.08.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054737105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jala.2009.08.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054737105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cb3001028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055226165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cc030008f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055227622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cc030008f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055227622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ci00057a005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055400944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ci900464s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055404884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ci900464s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055404884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm301292a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055953366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1105511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062451237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/0929867023368773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069159855"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-12", 
        "datePublishedReg": "2015-12-01", 
        "description": "High-throughput screening (HTS) is an integral part of early drug discovery. Herein, we focused on those small molecules in a screening collection that have never shown biological activity despite having been exhaustively tested in HTS assays. These compounds are referred to as 'dark chemical matter' (DCM). We quantified DCM, validated it in quality control experiments, described its physicochemical properties and mapped it into chemical space. Through analysis of prospective reporter-gene assay, gene expression and yeast chemogenomics experiments, we evaluated the potential of DCM to show biological activity in future screens. We demonstrated that, despite the apparent lack of activity, occasionally these compounds can result in potent hits with unique activity and clean safety profiles, which makes them valuable starting points for lead optimization efforts. Among the identified DCM hits was a new antifungal chemotype with strong activity against the pathogen Cryptococcus neoformans but little activity at targets relevant to human safety. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nchembio.1936", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1327431", 
            "issn": [
              "1552-4450", 
              "1552-4469"
            ], 
            "name": "Nature Chemical Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "11"
          }
        ], 
        "name": "Dark chemical matter as a promising starting point for drug lead discovery", 
        "pagination": "958-966", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "be0dfa0bf9229d1abf1ca86c60a14f0027576504a785677740309156622beb3b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26479441"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101231976"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nchembio.1936"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1039897559"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nchembio.1936", 
          "https://app.dimensions.ai/details/publication/pub.1039897559"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:29", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000425.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nchembio/journal/v11/n12/full/nchembio.1936.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nchembio.1936'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nchembio.1936'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nchembio.1936'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nchembio.1936'


     

    This table displays all metadata directly associated to this object as RDF triples.

    342 TRIPLES      21 PREDICATES      74 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nchembio.1936 schema:about N1974052796324e528cc833b2255ca1f3
    2 N3e98c61678624239ab695529fa8c0efa
    3 N4e29ea6315674553b38f9d4928127141
    4 N53bcfaa785974a3fa4165daa40ef80f1
    5 N56d571d070e347cea25aa60d785eb544
    6 N9872180a723b4880a84de405c6aca2d8
    7 Nbcf5614fe68b465c91e663383a7235b6
    8 anzsrc-for:06
    9 anzsrc-for:0601
    10 schema:author N5229bd7cc772415592b6fa65bbe91e88
    11 schema:citation sg:pub.10.1038/nature03192
    12 sg:pub.10.1038/nchem.1243
    13 sg:pub.10.1038/nchembio0709-441
    14 sg:pub.10.1038/nrd3367
    15 sg:pub.10.1038/nrd3368
    16 sg:pub.10.1186/1687-4153-2012-2
    17 sg:pub.10.1186/1758-2946-4-39
    18 https://doi.org/10.1002/(sici)1097-0061(199611)12:14<1421::aid-yea38>3.0.co;2-w
    19 https://doi.org/10.1002/cmdc.200700036
    20 https://doi.org/10.1002/cmdc.201402129
    21 https://doi.org/10.1016/j.cbpa.2004.06.004
    22 https://doi.org/10.1016/j.drudis.2013.02.005
    23 https://doi.org/10.1016/j.jala.2009.08.001
    24 https://doi.org/10.1016/j.micres.2013.11.004
    25 https://doi.org/10.1016/s0169-409x(00)00129-0
    26 https://doi.org/10.1021/cb3001028
    27 https://doi.org/10.1021/cc030008f
    28 https://doi.org/10.1021/ci00057a005
    29 https://doi.org/10.1021/ci050352v
    30 https://doi.org/10.1021/ci100050t
    31 https://doi.org/10.1021/ci900464s
    32 https://doi.org/10.1021/jm301292a
    33 https://doi.org/10.1021/jm401120g
    34 https://doi.org/10.1021/jm9602928
    35 https://doi.org/10.1042/bj2770017
    36 https://doi.org/10.1073/pnas.1410933111
    37 https://doi.org/10.1093/nar/gkr1132
    38 https://doi.org/10.1093/nar/gkr777
    39 https://doi.org/10.1093/nar/gkt978
    40 https://doi.org/10.1093/nar/gku1214
    41 https://doi.org/10.1096/fj.10-170811
    42 https://doi.org/10.1126/science.1060762
    43 https://doi.org/10.1126/science.1105511
    44 https://doi.org/10.1126/science.1250217
    45 https://doi.org/10.1145/364520.364540
    46 https://doi.org/10.2174/0929867023368773
    47 https://doi.org/10.4155/fmc.09.51
    48 https://doi.org/10.4155/fmc.14.72
    49 schema:datePublished 2015-12
    50 schema:datePublishedReg 2015-12-01
    51 schema:description High-throughput screening (HTS) is an integral part of early drug discovery. Herein, we focused on those small molecules in a screening collection that have never shown biological activity despite having been exhaustively tested in HTS assays. These compounds are referred to as 'dark chemical matter' (DCM). We quantified DCM, validated it in quality control experiments, described its physicochemical properties and mapped it into chemical space. Through analysis of prospective reporter-gene assay, gene expression and yeast chemogenomics experiments, we evaluated the potential of DCM to show biological activity in future screens. We demonstrated that, despite the apparent lack of activity, occasionally these compounds can result in potent hits with unique activity and clean safety profiles, which makes them valuable starting points for lead optimization efforts. Among the identified DCM hits was a new antifungal chemotype with strong activity against the pathogen Cryptococcus neoformans but little activity at targets relevant to human safety.
    52 schema:genre research_article
    53 schema:inLanguage en
    54 schema:isAccessibleForFree false
    55 schema:isPartOf N2ba68e7fad59471e9b3ee3d82b925e79
    56 Ncbc97b434fe446b5ab7f1ef3797f2afc
    57 sg:journal.1327431
    58 schema:name Dark chemical matter as a promising starting point for drug lead discovery
    59 schema:pagination 958-966
    60 schema:productId N0085a2e11a6049b08df87643df6bea13
    61 N7745e158391c47c583dd81ae0c670b94
    62 N891fc31ae7bc4c0a88ca719a283824a1
    63 Ndf679030d78242f987fae21cd524155b
    64 Nfd4619a412e1467583ec89e137bceebd
    65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039897559
    66 https://doi.org/10.1038/nchembio.1936
    67 schema:sdDatePublished 2019-04-10T16:29
    68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    69 schema:sdPublisher Nefaad01f54da43c48b79872e74b3d193
    70 schema:url http://www.nature.com/nchembio/journal/v11/n12/full/nchembio.1936.html
    71 sgo:license sg:explorer/license/
    72 sgo:sdDataset articles
    73 rdf:type schema:ScholarlyArticle
    74 N0085a2e11a6049b08df87643df6bea13 schema:name pubmed_id
    75 schema:value 26479441
    76 rdf:type schema:PropertyValue
    77 N0cbd1c1fa3544af0a41f83c6a608a27f rdf:first sg:person.01025163525.84
    78 rdf:rest N8086c07d5ecf423f95689229008fe6d1
    79 N1974052796324e528cc833b2255ca1f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Structure-Activity Relationship
    81 rdf:type schema:DefinedTerm
    82 N2257b9a9a29545929b9291cac9945390 rdf:first sg:person.0602726441.08
    83 rdf:rest rdf:nil
    84 N261c978d443f420e88bf3d75c715eef8 rdf:first sg:person.0671724111.74
    85 rdf:rest N5f25f685dbe249528545dc9948956cd9
    86 N2ba68e7fad59471e9b3ee3d82b925e79 schema:volumeNumber 11
    87 rdf:type schema:PublicationVolume
    88 N2c6e0f45f82645bda92b979094d89739 rdf:first Nab328cb35a884d5685359c98c9030d09
    89 rdf:rest Nb3eb6dda5f2d43c19a5328cffe8b15c2
    90 N3e98c61678624239ab695529fa8c0efa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    91 schema:name High-Throughput Screening Assays
    92 rdf:type schema:DefinedTerm
    93 N3f726ae009d54eddb0e6488a9197ca45 rdf:first sg:person.01304235105.10
    94 rdf:rest Ne5c25818785c4fa9b08b73ccf5b9ee59
    95 N4e29ea6315674553b38f9d4928127141 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Molecular Structure
    97 rdf:type schema:DefinedTerm
    98 N5229bd7cc772415592b6fa65bbe91e88 rdf:first sg:person.01024677500.05
    99 rdf:rest N7c67fa9426c9485f91754c3a210caa43
    100 N53bcfaa785974a3fa4165daa40ef80f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Cryptococcus neoformans
    102 rdf:type schema:DefinedTerm
    103 N56d571d070e347cea25aa60d785eb544 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Antifungal Agents
    105 rdf:type schema:DefinedTerm
    106 N5f25f685dbe249528545dc9948956cd9 rdf:first sg:person.01213323641.45
    107 rdf:rest N3f726ae009d54eddb0e6488a9197ca45
    108 N6f3bccb3da63426eac03c7649503265f rdf:first sg:person.01326332541.60
    109 rdf:rest N2257b9a9a29545929b9291cac9945390
    110 N7592010d4bfc423abcb22036ca2ef9a4 rdf:first sg:person.01273152475.06
    111 rdf:rest Nc9ea9f1ac3df4b47bfb9506da4f86e95
    112 N7745e158391c47c583dd81ae0c670b94 schema:name doi
    113 schema:value 10.1038/nchembio.1936
    114 rdf:type schema:PropertyValue
    115 N7c67fa9426c9485f91754c3a210caa43 rdf:first sg:person.01260774030.19
    116 rdf:rest N261c978d443f420e88bf3d75c715eef8
    117 N8086c07d5ecf423f95689229008fe6d1 rdf:first sg:person.01140374426.64
    118 rdf:rest Nd336dc471ef24eb68d42bc640298e944
    119 N8326172ec49f401aad489bad36a2b453 rdf:first sg:person.0725154362.45
    120 rdf:rest Nb1bcff3a46b0486dba12dbc7da6be8e0
    121 N891fc31ae7bc4c0a88ca719a283824a1 schema:name dimensions_id
    122 schema:value pub.1039897559
    123 rdf:type schema:PropertyValue
    124 N9872180a723b4880a84de405c6aca2d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Microbial Sensitivity Tests
    126 rdf:type schema:DefinedTerm
    127 Nab328cb35a884d5685359c98c9030d09 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
    128 schema:familyName Peltier
    129 schema:givenName John M
    130 rdf:type schema:Person
    131 Nb1bcff3a46b0486dba12dbc7da6be8e0 rdf:first sg:person.01236551443.87
    132 rdf:rest Ne5076ff4277f486c9214305417903209
    133 Nb3eb6dda5f2d43c19a5328cffe8b15c2 rdf:first Nbbab4f504c9142f19ce1f8f95b6aa700
    134 rdf:rest N8326172ec49f401aad489bad36a2b453
    135 Nbbab4f504c9142f19ce1f8f95b6aa700 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
    136 schema:familyName Grippo
    137 schema:givenName Melissa L
    138 rdf:type schema:Person
    139 Nbcf5614fe68b465c91e663383a7235b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Drug Discovery
    141 rdf:type schema:DefinedTerm
    142 Nc9ea9f1ac3df4b47bfb9506da4f86e95 rdf:first sg:person.0612327172.32
    143 rdf:rest N0cbd1c1fa3544af0a41f83c6a608a27f
    144 Ncbc97b434fe446b5ab7f1ef3797f2afc schema:issueNumber 12
    145 rdf:type schema:PublicationIssue
    146 Nd336dc471ef24eb68d42bc640298e944 rdf:first sg:person.01032066755.02
    147 rdf:rest N6f3bccb3da63426eac03c7649503265f
    148 Ndf679030d78242f987fae21cd524155b schema:name readcube_id
    149 schema:value be0dfa0bf9229d1abf1ca86c60a14f0027576504a785677740309156622beb3b
    150 rdf:type schema:PropertyValue
    151 Ne5076ff4277f486c9214305417903209 rdf:first sg:person.01175336460.80
    152 rdf:rest N7592010d4bfc423abcb22036ca2ef9a4
    153 Ne5c25818785c4fa9b08b73ccf5b9ee59 rdf:first sg:person.0705267411.90
    154 rdf:rest N2c6e0f45f82645bda92b979094d89739
    155 Nefaad01f54da43c48b79872e74b3d193 schema:name Springer Nature - SN SciGraph project
    156 rdf:type schema:Organization
    157 Nfd4619a412e1467583ec89e137bceebd schema:name nlm_unique_id
    158 schema:value 101231976
    159 rdf:type schema:PropertyValue
    160 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    161 schema:name Biological Sciences
    162 rdf:type schema:DefinedTerm
    163 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    164 schema:name Biochemistry and Cell Biology
    165 rdf:type schema:DefinedTerm
    166 sg:journal.1327431 schema:issn 1552-4450
    167 1552-4469
    168 schema:name Nature Chemical Biology
    169 rdf:type schema:Periodical
    170 sg:person.01024677500.05 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
    171 schema:familyName Wassermann
    172 schema:givenName Anne Mai
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024677500.05
    174 rdf:type schema:Person
    175 sg:person.01025163525.84 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
    176 schema:familyName Krastel
    177 schema:givenName Philipp
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025163525.84
    179 rdf:type schema:Person
    180 sg:person.01032066755.02 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
    181 schema:familyName Parker
    182 schema:givenName Christian N
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032066755.02
    184 rdf:type schema:Person
    185 sg:person.01140374426.64 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
    186 schema:familyName Cobos-Correa
    187 schema:givenName Amanda
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140374426.64
    189 rdf:type schema:Person
    190 sg:person.01175336460.80 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
    191 schema:familyName Schuffenhauer
    192 schema:givenName Ansgar
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175336460.80
    194 rdf:type schema:Person
    195 sg:person.01213323641.45 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
    196 schema:familyName Le Goff
    197 schema:givenName Gaelle
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213323641.45
    199 rdf:type schema:Person
    200 sg:person.01236551443.87 schema:affiliation https://www.grid.ac/institutes/grid.418185.1
    201 schema:familyName Tao
    202 schema:givenName Jianshi
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236551443.87
    204 rdf:type schema:Person
    205 sg:person.01260774030.19 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
    206 schema:familyName Lounkine
    207 schema:givenName Eugen
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260774030.19
    209 rdf:type schema:Person
    210 sg:person.01273152475.06 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
    211 schema:familyName Wallace
    212 schema:givenName Iain M
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273152475.06
    214 rdf:type schema:Person
    215 sg:person.01304235105.10 schema:affiliation https://www.grid.ac/institutes/grid.418185.1
    216 schema:familyName King
    217 schema:givenName Frederick J
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304235105.10
    219 rdf:type schema:Person
    220 sg:person.01326332541.60 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
    221 schema:familyName Davies
    222 schema:givenName John W
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326332541.60
    224 rdf:type schema:Person
    225 sg:person.0602726441.08 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
    226 schema:familyName Glick
    227 schema:givenName Meir
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602726441.08
    229 rdf:type schema:Person
    230 sg:person.0612327172.32 schema:affiliation https://www.grid.ac/institutes/grid.418424.f
    231 schema:familyName Chen
    232 schema:givenName Shanni
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612327172.32
    234 rdf:type schema:Person
    235 sg:person.0671724111.74 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
    236 schema:familyName Hoepfner
    237 schema:givenName Dominic
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671724111.74
    239 rdf:type schema:Person
    240 sg:person.0705267411.90 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
    241 schema:familyName Studer
    242 schema:givenName Christian
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705267411.90
    244 rdf:type schema:Person
    245 sg:person.0725154362.45 schema:affiliation https://www.grid.ac/institutes/grid.418185.1
    246 schema:familyName Prindle
    247 schema:givenName Vivian
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725154362.45
    249 rdf:type schema:Person
    250 sg:pub.10.1038/nature03192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040832969
    251 https://doi.org/10.1038/nature03192
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nchem.1243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009671604
    254 https://doi.org/10.1038/nchem.1243
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/nchembio0709-441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016974153
    257 https://doi.org/10.1038/nchembio0709-441
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/nrd3367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035797641
    260 https://doi.org/10.1038/nrd3367
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/nrd3368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041527430
    263 https://doi.org/10.1038/nrd3368
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1186/1687-4153-2012-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009797683
    266 https://doi.org/10.1186/1687-4153-2012-2
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1186/1758-2946-4-39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037214563
    269 https://doi.org/10.1186/1758-2946-4-39
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1002/(sici)1097-0061(199611)12:14<1421::aid-yea38>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1027264470
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/cmdc.200700036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015973334
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1002/cmdc.201402129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032948586
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.cbpa.2004.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033891139
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.drudis.2013.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043656376
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.jala.2009.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054737105
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.micres.2013.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006712670
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/s0169-409x(00)00129-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006677292
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1021/cb3001028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055226165
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1021/cc030008f schema:sameAs https://app.dimensions.ai/details/publication/pub.1055227622
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1021/ci00057a005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055400944
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1021/ci050352v schema:sameAs https://app.dimensions.ai/details/publication/pub.1047984405
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1021/ci100050t schema:sameAs https://app.dimensions.ai/details/publication/pub.1016898407
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1021/ci900464s schema:sameAs https://app.dimensions.ai/details/publication/pub.1055404884
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1021/jm301292a schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953366
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1021/jm401120g schema:sameAs https://app.dimensions.ai/details/publication/pub.1019936584
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1021/jm9602928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011887615
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1042/bj2770017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011177123
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1073/pnas.1410933111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001570523
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1093/nar/gkr1132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043796486
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1093/nar/gkr777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002983472
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1093/nar/gkt978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014842119
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1093/nar/gku1214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006546975
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1096/fj.10-170811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035630875
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1126/science.1060762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033500451
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1126/science.1105511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062451237
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1126/science.1250217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020589828
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1145/364520.364540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053610335
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.2174/0929867023368773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069159855
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.4155/fmc.09.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047359531
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.4155/fmc.14.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002746588
    332 rdf:type schema:CreativeWork
    333 https://www.grid.ac/institutes/grid.418185.1 schema:alternateName Genomics Institute of the Novartis Research Foundation
    334 schema:name Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA.
    335 The Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.
    336 rdf:type schema:Organization
    337 https://www.grid.ac/institutes/grid.418424.f schema:alternateName Novartis (United States)
    338 schema:name Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA.
    339 rdf:type schema:Organization
    340 https://www.grid.ac/institutes/grid.419481.1 schema:alternateName Novartis (Switzerland)
    341 schema:name Novartis Institutes for BioMedical Research Inc., Basel, Switzerland.
    342 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...