5-Formylcytosine can be a stable DNA modification in mammals View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-08

AUTHORS

Martin Bachman, Santiago Uribe-Lewis, Xiaoping Yang, Heather E Burgess, Mario Iurlaro, Wolf Reik, Adele Murrell, Shankar Balasubramanian

ABSTRACT

5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC can be a stable DNA modification. These results suggest that 5fC has functional roles in DNA that go beyond being a demethylation intermediate. More... »

PAGES

555-557

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio.1848

DOI

http://dx.doi.org/10.1038/nchembio.1848

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021651811

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26098680


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