Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-03

AUTHORS

Céline Galvagnion, Alexander K Buell, Georg Meisl, Thomas C T Michaels, Michele Vendruscolo, Tuomas P J Knowles, Christopher M Dobson

ABSTRACT

α-Synuclein (α-syn) is a 140-residue intrinsically disordered protein that is involved in neuronal and synaptic vesicle plasticity, but its aggregation to form amyloid fibrils is the hallmark of Parkinson's disease (PD). The interaction between α-syn and lipid surfaces is believed to be a key feature for mediation of its normal function, but under other circumstances it is able to modulate amyloid fibril formation. Using a combination of experimental and theoretical approaches, we identify the mechanism through which facile aggregation of α-syn is induced under conditions where it binds a lipid bilayer, and we show that the rate of primary nucleation can be enhanced by three orders of magnitude or more under such conditions. These results reveal the key role that membrane interactions can have in triggering conversion of α-syn from its soluble state to the aggregated state that is associated with neurodegeneration and to its associated disease states. More... »

PAGES

229-234

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio.1750

DOI

http://dx.doi.org/10.1038/nchembio.1750

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033765634

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25643172


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