Brownian search-and-catch mechanism for myosin-VI steps View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-05-10

AUTHORS

Mitsuhiro Iwaki, Atsuko H Iwane, Tetsuya Shimokawa, Roger Cooke, Toshio Yanagida

ABSTRACT

The cargo transporter myosin-VI processively walks along actin filaments using its two heads. Here we use single-molecule nanometry to show that the strong binding by myosin heads to actin is greatly accelerated (approximately 30-fold) when backward strain is applied to weakly bound heads during the actin search. We propose that the myosin head searches for the forward actin target by Brownian motion and catches the actin in a strain-dependent manner. More... »

PAGES

403-405

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio.171

DOI

http://dx.doi.org/10.1038/nchembio.171

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025715638

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19430485


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