The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-09

AUTHORS

Georg E Winter, Branka Radic, Cristina Mayor-Ruiz, Vincent A Blomen, Claudia Trefzer, Richard K Kandasamy, Kilian V M Huber, Manuela Gridling, Doris Chen, Thorsten Klampfl, Robert Kralovics, Stefan Kubicek, Oscar Fernandez-Capetillo, Thijn R Brummelkamp, Giulio Superti-Furga

ABSTRACT

Genotoxic chemotherapy is the most common cancer treatment strategy. However, its untargeted generic DNA-damaging nature and associated systemic cytotoxicity greatly limit its therapeutic applications. Here, we used a haploid genetic screen in human cells to discover an absolute dependency of the clinically evaluated anticancer compound YM155 on solute carrier family member 35 F2 (SLC35F2), an uncharacterized member of the solute carrier protein family that is highly expressed in a variety of human cancers. YM155 generated DNA damage through intercalation, which was contingent on the expression of SLC35F2 and its drug-importing activity. SLC35F2 expression and YM155 sensitivity correlated across a panel of cancer cell lines, and targeted genome editing verified SLC35F2 as the main determinant of YM155-mediated DNA damage toxicity in vitro and in vivo. These findings suggest a new route to targeted DNA damage by exploiting tumor and patient-specific import of YM155. More... »

PAGES

768

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio.1590

DOI

http://dx.doi.org/10.1038/nchembio.1590

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000807818

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25064833


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cloning, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Comet Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haploidy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imidazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intercalating Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Naphthoquinones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Neoplasm", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "CeMM Research Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.418729.1", 
          "name": [
            "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winter", 
        "givenName": "Georg E", 
        "id": "sg:person.01264263320.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264263320.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CeMM Research Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.418729.1", 
          "name": [
            "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Radic", 
        "givenName": "Branka", 
        "id": "sg:person.01060422764.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060422764.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spanish National Cancer Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayor-Ruiz", 
        "givenName": "Cristina", 
        "id": "sg:person.01263735670.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263735670.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Antoni van Leeuwenhoek Hospital", 
          "id": "https://www.grid.ac/institutes/grid.430814.a", 
          "name": [
            "Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blomen", 
        "givenName": "Vincent A", 
        "id": "sg:person.01311317774.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311317774.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CeMM Research Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.418729.1", 
          "name": [
            "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trefzer", 
        "givenName": "Claudia", 
        "id": "sg:person.0606444770.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606444770.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CeMM Research Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.418729.1", 
          "name": [
            "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kandasamy", 
        "givenName": "Richard K", 
        "id": "sg:person.0654560170.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654560170.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CeMM Research Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.418729.1", 
          "name": [
            "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huber", 
        "givenName": "Kilian V M", 
        "id": "sg:person.010156175642.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010156175642.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CeMM Research Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.418729.1", 
          "name": [
            "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gridling", 
        "givenName": "Manuela", 
        "id": "sg:person.0645422133.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645422133.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CeMM Research Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.418729.1", 
          "name": [
            "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Doris", 
        "id": "sg:person.01101407066.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101407066.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CeMM Research Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.418729.1", 
          "name": [
            "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klampfl", 
        "givenName": "Thorsten", 
        "id": "sg:person.01253171460.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253171460.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CeMM Research Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.418729.1", 
          "name": [
            "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kralovics", 
        "givenName": "Robert", 
        "id": "sg:person.0667335326.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667335326.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CeMM Research Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.418729.1", 
          "name": [
            "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kubicek", 
        "givenName": "Stefan", 
        "id": "sg:person.0611375454.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611375454.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spanish National Cancer Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fernandez-Capetillo", 
        "givenName": "Oscar", 
        "id": "sg:person.01107263432.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107263432.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Antoni van Leeuwenhoek Hospital", 
          "id": "https://www.grid.ac/institutes/grid.430814.a", 
          "name": [
            "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.", 
            "Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, the Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brummelkamp", 
        "givenName": "Thijn R", 
        "id": "sg:person.01260666542.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260666542.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CeMM Research Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.418729.1", 
          "name": [
            "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Superti-Furga", 
        "givenName": "Giulio", 
        "id": "sg:person.01307321704.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307321704.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature01368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002815475", 
          "https://doi.org/10.1038/nature01368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002815475", 
          "https://doi.org/10.1038/nature01368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1018098108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005157052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1741-7007-9-70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005280446", 
          "https://doi.org/10.1186/1741-7007-9-70"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m111.013243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009590840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012425816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.04.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013935649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-012-1868-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015529180", 
          "https://doi.org/10.1007/s00280-012-1868-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.21.1862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017705614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1231143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019873131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1178955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021305975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1232033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022072971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00424-003-1093-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024635288", 
          "https://doi.org/10.1007/s00424-003-1093-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025907389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.108.025254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027378134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.redox.2013.12.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028603209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mam.2012.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030031899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1002965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034099884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036060000", 
          "https://doi.org/10.1038/nature11003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.109.028142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039886929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040790799", 
          "https://doi.org/10.1038/nbt.1857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drudis.2011.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042585947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1209124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042743567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043232906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045987740", 
          "https://doi.org/10.1038/nrd2438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.452308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047409631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.54.2.521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048838243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd3028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049513504", 
          "https://doi.org/10.1038/nrd3028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd3028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049513504", 
          "https://doi.org/10.1038/nrd3028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2009-10-3-r25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049583368", 
          "https://doi.org/10.1186/gb-2009-10-3-r25"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0704182104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052791843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053270214", 
          "https://doi.org/10.1038/ng.2471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.17.2064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053423247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.183.4120.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062508832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.3.1.570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072293188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076631468", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-09", 
    "datePublishedReg": "2014-09-01", 
    "description": "Genotoxic chemotherapy is the most common cancer treatment strategy. However, its untargeted generic DNA-damaging nature and associated systemic cytotoxicity greatly limit its therapeutic applications. Here, we used a haploid genetic screen in human cells to discover an absolute dependency of the clinically evaluated anticancer compound YM155 on solute carrier family member 35 F2 (SLC35F2), an uncharacterized member of the solute carrier protein family that is highly expressed in a variety of human cancers. YM155 generated DNA damage through intercalation, which was contingent on the expression of SLC35F2 and its drug-importing activity. SLC35F2 expression and YM155 sensitivity correlated across a panel of cancer cell lines, and targeted genome editing verified SLC35F2 as the main determinant of YM155-mediated DNA damage toxicity in vitro and in vivo. These findings suggest a new route to targeted DNA damage by exploiting tumor and patient-specific import of YM155. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nchembio.1590", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5149125", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3795749", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3784985", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1327431", 
        "issn": [
          "1552-4450", 
          "1552-4469"
        ], 
        "name": "Nature Chemical Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity", 
    "pagination": "768", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "03d8cd085e4215f533507c3e2a7a2a7e86cc4dad95761abca36b99cc57d53d24"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25064833"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101231976"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nchembio.1590"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000807818"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nchembio.1590", 
      "https://app.dimensions.ai/details/publication/pub.1000807818"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000509.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nchembio.1590"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nchembio.1590'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nchembio.1590'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nchembio.1590'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nchembio.1590'


 

This table displays all metadata directly associated to this object as RDF triples.

370 TRIPLES      21 PREDICATES      83 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nchembio.1590 schema:about N0299e0d8b57746baa8ab5f1e27492a37
2 N0495c9a1f7cd40998bd30d21bc24976f
3 N0b26dc2b111c4bb0a8efe7161045734b
4 N13231dfd3012485bb142b93d31c9b359
5 N140adc84c3ef4889b8b5452b63c8e88d
6 N1e8c0c056a5245af883f18d0da786c52
7 N2cba1aefc7dd481ba090ad9f22876b0a
8 N348aff13a2814750bb74292366391465
9 N3706dfe663864c51872a71e1584b5612
10 N43615a957303486a9e762f659837f207
11 N50b947826b724eeb84a2a9f67380052e
12 N6745f0759abb4a14ba5bbc82017b1243
13 N73c662dcbcd849e38ff30b4181c5c7d2
14 N779699045f4240938dc525bbce62629b
15 N84dc7bd2a6b54306a4cfa636c0e1b2f2
16 Nb442b4fc5899465aa3e34e2ece0e78a6
17 Nd002f12a9d304b1e9c1fd8b2aa4ec219
18 Nd5256dad5da24a0e97a739e9d0089cfd
19 Nf6d16d45b92644eea0e05d0b3462b452
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author N625c5e515fb04efab9c06b440ba58786
23 schema:citation sg:pub.10.1007/s00280-012-1868-0
24 sg:pub.10.1007/s00424-003-1093-0
25 sg:pub.10.1038/nature01368
26 sg:pub.10.1038/nature11003
27 sg:pub.10.1038/nbt.1857
28 sg:pub.10.1038/ng.2471
29 sg:pub.10.1038/nrd2438
30 sg:pub.10.1038/nrd3028
31 sg:pub.10.1186/1741-7007-9-70
32 sg:pub.10.1186/gb-2009-10-3-r25
33 https://app.dimensions.ai/details/publication/pub.1076631468
34 https://doi.org/10.1016/j.cell.2013.04.025
35 https://doi.org/10.1016/j.drudis.2011.05.010
36 https://doi.org/10.1016/j.mam.2012.12.004
37 https://doi.org/10.1016/j.redox.2013.12.020
38 https://doi.org/10.1056/nejmoa1002965
39 https://doi.org/10.1056/nejmoa1209124
40 https://doi.org/10.1073/pnas.0506580102
41 https://doi.org/10.1073/pnas.0704182104
42 https://doi.org/10.1073/pnas.1018098108
43 https://doi.org/10.1073/pnas.54.2.521
44 https://doi.org/10.1074/mcp.m111.013243
45 https://doi.org/10.1093/bioinformatics/btp120
46 https://doi.org/10.1093/bioinformatics/btp612
47 https://doi.org/10.1093/bioinformatics/bts356
48 https://doi.org/10.1101/gad.452308
49 https://doi.org/10.1124/dmd.108.025254
50 https://doi.org/10.1124/dmd.109.028142
51 https://doi.org/10.1126/science.1178955
52 https://doi.org/10.1126/science.1231143
53 https://doi.org/10.1126/science.1232033
54 https://doi.org/10.1126/science.183.4120.46
55 https://doi.org/10.1200/jco.2008.17.2064
56 https://doi.org/10.1200/jco.2008.21.1862
57 https://doi.org/10.4161/cbt.3.1.570
58 schema:datePublished 2014-09
59 schema:datePublishedReg 2014-09-01
60 schema:description Genotoxic chemotherapy is the most common cancer treatment strategy. However, its untargeted generic DNA-damaging nature and associated systemic cytotoxicity greatly limit its therapeutic applications. Here, we used a haploid genetic screen in human cells to discover an absolute dependency of the clinically evaluated anticancer compound YM155 on solute carrier family member 35 F2 (SLC35F2), an uncharacterized member of the solute carrier protein family that is highly expressed in a variety of human cancers. YM155 generated DNA damage through intercalation, which was contingent on the expression of SLC35F2 and its drug-importing activity. SLC35F2 expression and YM155 sensitivity correlated across a panel of cancer cell lines, and targeted genome editing verified SLC35F2 as the main determinant of YM155-mediated DNA damage toxicity in vitro and in vivo. These findings suggest a new route to targeted DNA damage by exploiting tumor and patient-specific import of YM155.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N67a0e6fb5c694a77b0e5c9ab77494084
65 Nc95a5b6cb0ea449b8b8fa24938dca6d2
66 sg:journal.1327431
67 schema:name The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity
68 schema:pagination 768
69 schema:productId N18bcc2746e0d4bd29e9d750a356d3fd0
70 Nce77f4e851eb4e3c83fe72756cb74915
71 Nf55dee8c41024e1e9ec465b61ed13309
72 Nfd3d989c808644d692f5414eea8e7f6b
73 Nfd92029e003740dd9e99b46556ffb2b4
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000807818
75 https://doi.org/10.1038/nchembio.1590
76 schema:sdDatePublished 2019-04-10T14:08
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nd6b68032711947c8bf15e12ee393c406
79 schema:url https://www.nature.com/articles/nchembio.1590
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N0299e0d8b57746baa8ab5f1e27492a37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Comet Assay
85 rdf:type schema:DefinedTerm
86 N0495c9a1f7cd40998bd30d21bc24976f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Cell Line, Tumor
88 rdf:type schema:DefinedTerm
89 N0a2820fe95954d649548f9d929317eed rdf:first sg:person.01101407066.17
90 rdf:rest N2db321e20f774d4ba17b56953ca4d033
91 N0b26dc2b111c4bb0a8efe7161045734b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Genome, Human
93 rdf:type schema:DefinedTerm
94 N115b4165e2724f528059e2d122a1224c rdf:first sg:person.0611375454.87
95 rdf:rest N2d776780af054aa28aaf5fae8381b837
96 N13231dfd3012485bb142b93d31c9b359 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Cell Division
98 rdf:type schema:DefinedTerm
99 N140adc84c3ef4889b8b5452b63c8e88d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Animals
101 rdf:type schema:DefinedTerm
102 N18bcc2746e0d4bd29e9d750a356d3fd0 schema:name readcube_id
103 schema:value 03d8cd085e4215f533507c3e2a7a2a7e86cc4dad95761abca36b99cc57d53d24
104 rdf:type schema:PropertyValue
105 N1e8c0c056a5245af883f18d0da786c52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Membrane Transport Proteins
107 rdf:type schema:DefinedTerm
108 N2cba1aefc7dd481ba090ad9f22876b0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Intercalating Agents
110 rdf:type schema:DefinedTerm
111 N2d776780af054aa28aaf5fae8381b837 rdf:first sg:person.01107263432.77
112 rdf:rest N672a5eaf849e4d409721658137fc5975
113 N2db321e20f774d4ba17b56953ca4d033 rdf:first sg:person.01253171460.85
114 rdf:rest N5d25cf9a000241e0ae1fa51e7550bc97
115 N348aff13a2814750bb74292366391465 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Haploidy
117 rdf:type schema:DefinedTerm
118 N3706dfe663864c51872a71e1584b5612 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Mice, SCID
120 rdf:type schema:DefinedTerm
121 N43615a957303486a9e762f659837f207 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name RNA, Neoplasm
123 rdf:type schema:DefinedTerm
124 N497881182bae434f948c64047977d73a rdf:first sg:person.0654560170.65
125 rdf:rest N83c627f05978499d9512cff1b700daab
126 N50b947826b724eeb84a2a9f67380052e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Cell Survival
128 rdf:type schema:DefinedTerm
129 N5d25cf9a000241e0ae1fa51e7550bc97 rdf:first sg:person.0667335326.40
130 rdf:rest N115b4165e2724f528059e2d122a1224c
131 N625c5e515fb04efab9c06b440ba58786 rdf:first sg:person.01264263320.59
132 rdf:rest Ne052840fce9048499b96f1d692518fd1
133 N672a5eaf849e4d409721658137fc5975 rdf:first sg:person.01260666542.51
134 rdf:rest Na59e06e3af1d463d97ac76ad673d8316
135 N6745f0759abb4a14ba5bbc82017b1243 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cloning, Molecular
137 rdf:type schema:DefinedTerm
138 N67a0e6fb5c694a77b0e5c9ab77494084 schema:volumeNumber 10
139 rdf:type schema:PublicationVolume
140 N73c662dcbcd849e38ff30b4181c5c7d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Imidazoles
142 rdf:type schema:DefinedTerm
143 N779699045f4240938dc525bbce62629b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Mice
145 rdf:type schema:DefinedTerm
146 N83319f375ccd4249ba3884f952fc1024 rdf:first sg:person.01263735670.12
147 rdf:rest N885b730b0a4d402680e5adfe4225d674
148 N83c627f05978499d9512cff1b700daab rdf:first sg:person.010156175642.33
149 rdf:rest Nd3a4c94cc6eb4bac8f519bfdab05f1fe
150 N84dc7bd2a6b54306a4cfa636c0e1b2f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Immunohistochemistry
152 rdf:type schema:DefinedTerm
153 N885b730b0a4d402680e5adfe4225d674 rdf:first sg:person.01311317774.61
154 rdf:rest Ncf45945c2a9d4cd1b49c0327036377b5
155 Na59e06e3af1d463d97ac76ad673d8316 rdf:first sg:person.01307321704.36
156 rdf:rest rdf:nil
157 Nb442b4fc5899465aa3e34e2ece0e78a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Humans
159 rdf:type schema:DefinedTerm
160 Nc95a5b6cb0ea449b8b8fa24938dca6d2 schema:issueNumber 9
161 rdf:type schema:PublicationIssue
162 Nce77f4e851eb4e3c83fe72756cb74915 schema:name nlm_unique_id
163 schema:value 101231976
164 rdf:type schema:PropertyValue
165 Ncf45945c2a9d4cd1b49c0327036377b5 rdf:first sg:person.0606444770.49
166 rdf:rest N497881182bae434f948c64047977d73a
167 Nd002f12a9d304b1e9c1fd8b2aa4ec219 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name DNA Damage
169 rdf:type schema:DefinedTerm
170 Nd3a4c94cc6eb4bac8f519bfdab05f1fe rdf:first sg:person.0645422133.00
171 rdf:rest N0a2820fe95954d649548f9d929317eed
172 Nd5256dad5da24a0e97a739e9d0089cfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Apoptosis
174 rdf:type schema:DefinedTerm
175 Nd6b68032711947c8bf15e12ee393c406 schema:name Springer Nature - SN SciGraph project
176 rdf:type schema:Organization
177 Ne052840fce9048499b96f1d692518fd1 rdf:first sg:person.01060422764.18
178 rdf:rest N83319f375ccd4249ba3884f952fc1024
179 Nf55dee8c41024e1e9ec465b61ed13309 schema:name dimensions_id
180 schema:value pub.1000807818
181 rdf:type schema:PropertyValue
182 Nf6d16d45b92644eea0e05d0b3462b452 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Naphthoquinones
184 rdf:type schema:DefinedTerm
185 Nfd3d989c808644d692f5414eea8e7f6b schema:name doi
186 schema:value 10.1038/nchembio.1590
187 rdf:type schema:PropertyValue
188 Nfd92029e003740dd9e99b46556ffb2b4 schema:name pubmed_id
189 schema:value 25064833
190 rdf:type schema:PropertyValue
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
195 schema:name Oncology and Carcinogenesis
196 rdf:type schema:DefinedTerm
197 sg:grant.3784985 http://pending.schema.org/fundedItem sg:pub.10.1038/nchembio.1590
198 rdf:type schema:MonetaryGrant
199 sg:grant.3795749 http://pending.schema.org/fundedItem sg:pub.10.1038/nchembio.1590
200 rdf:type schema:MonetaryGrant
201 sg:grant.5149125 http://pending.schema.org/fundedItem sg:pub.10.1038/nchembio.1590
202 rdf:type schema:MonetaryGrant
203 sg:journal.1327431 schema:issn 1552-4450
204 1552-4469
205 schema:name Nature Chemical Biology
206 rdf:type schema:Periodical
207 sg:person.010156175642.33 schema:affiliation https://www.grid.ac/institutes/grid.418729.1
208 schema:familyName Huber
209 schema:givenName Kilian V M
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010156175642.33
211 rdf:type schema:Person
212 sg:person.01060422764.18 schema:affiliation https://www.grid.ac/institutes/grid.418729.1
213 schema:familyName Radic
214 schema:givenName Branka
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060422764.18
216 rdf:type schema:Person
217 sg:person.01101407066.17 schema:affiliation https://www.grid.ac/institutes/grid.418729.1
218 schema:familyName Chen
219 schema:givenName Doris
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101407066.17
221 rdf:type schema:Person
222 sg:person.01107263432.77 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
223 schema:familyName Fernandez-Capetillo
224 schema:givenName Oscar
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107263432.77
226 rdf:type schema:Person
227 sg:person.01253171460.85 schema:affiliation https://www.grid.ac/institutes/grid.418729.1
228 schema:familyName Klampfl
229 schema:givenName Thorsten
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253171460.85
231 rdf:type schema:Person
232 sg:person.01260666542.51 schema:affiliation https://www.grid.ac/institutes/grid.430814.a
233 schema:familyName Brummelkamp
234 schema:givenName Thijn R
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260666542.51
236 rdf:type schema:Person
237 sg:person.01263735670.12 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
238 schema:familyName Mayor-Ruiz
239 schema:givenName Cristina
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263735670.12
241 rdf:type schema:Person
242 sg:person.01264263320.59 schema:affiliation https://www.grid.ac/institutes/grid.418729.1
243 schema:familyName Winter
244 schema:givenName Georg E
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264263320.59
246 rdf:type schema:Person
247 sg:person.01307321704.36 schema:affiliation https://www.grid.ac/institutes/grid.418729.1
248 schema:familyName Superti-Furga
249 schema:givenName Giulio
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307321704.36
251 rdf:type schema:Person
252 sg:person.01311317774.61 schema:affiliation https://www.grid.ac/institutes/grid.430814.a
253 schema:familyName Blomen
254 schema:givenName Vincent A
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311317774.61
256 rdf:type schema:Person
257 sg:person.0606444770.49 schema:affiliation https://www.grid.ac/institutes/grid.418729.1
258 schema:familyName Trefzer
259 schema:givenName Claudia
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606444770.49
261 rdf:type schema:Person
262 sg:person.0611375454.87 schema:affiliation https://www.grid.ac/institutes/grid.418729.1
263 schema:familyName Kubicek
264 schema:givenName Stefan
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611375454.87
266 rdf:type schema:Person
267 sg:person.0645422133.00 schema:affiliation https://www.grid.ac/institutes/grid.418729.1
268 schema:familyName Gridling
269 schema:givenName Manuela
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645422133.00
271 rdf:type schema:Person
272 sg:person.0654560170.65 schema:affiliation https://www.grid.ac/institutes/grid.418729.1
273 schema:familyName Kandasamy
274 schema:givenName Richard K
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654560170.65
276 rdf:type schema:Person
277 sg:person.0667335326.40 schema:affiliation https://www.grid.ac/institutes/grid.418729.1
278 schema:familyName Kralovics
279 schema:givenName Robert
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667335326.40
281 rdf:type schema:Person
282 sg:pub.10.1007/s00280-012-1868-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015529180
283 https://doi.org/10.1007/s00280-012-1868-0
284 rdf:type schema:CreativeWork
285 sg:pub.10.1007/s00424-003-1093-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024635288
286 https://doi.org/10.1007/s00424-003-1093-0
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nature01368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002815475
289 https://doi.org/10.1038/nature01368
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nature11003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036060000
292 https://doi.org/10.1038/nature11003
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nbt.1857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040790799
295 https://doi.org/10.1038/nbt.1857
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/ng.2471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053270214
298 https://doi.org/10.1038/ng.2471
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/nrd2438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045987740
301 https://doi.org/10.1038/nrd2438
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/nrd3028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049513504
304 https://doi.org/10.1038/nrd3028
305 rdf:type schema:CreativeWork
306 sg:pub.10.1186/1741-7007-9-70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005280446
307 https://doi.org/10.1186/1741-7007-9-70
308 rdf:type schema:CreativeWork
309 sg:pub.10.1186/gb-2009-10-3-r25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049583368
310 https://doi.org/10.1186/gb-2009-10-3-r25
311 rdf:type schema:CreativeWork
312 https://app.dimensions.ai/details/publication/pub.1076631468 schema:CreativeWork
313 https://doi.org/10.1016/j.cell.2013.04.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013935649
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.drudis.2011.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042585947
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.mam.2012.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030031899
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.redox.2013.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028603209
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1056/nejmoa1002965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034099884
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1056/nejmoa1209124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042743567
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1073/pnas.0704182104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052791843
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1073/pnas.1018098108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005157052
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1073/pnas.54.2.521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048838243
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1074/mcp.m111.013243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009590840
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1093/bioinformatics/btp120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012425816
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/bioinformatics/btp612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043232906
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1093/bioinformatics/bts356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025907389
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1101/gad.452308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047409631
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1124/dmd.108.025254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027378134
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1124/dmd.109.028142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039886929
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1126/science.1178955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021305975
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1126/science.1231143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019873131
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1126/science.1232033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022072971
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1126/science.183.4120.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062508832
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1200/jco.2008.17.2064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053423247
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1200/jco.2008.21.1862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017705614
358 rdf:type schema:CreativeWork
359 https://doi.org/10.4161/cbt.3.1.570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293188
360 rdf:type schema:CreativeWork
361 https://www.grid.ac/institutes/grid.418729.1 schema:alternateName CeMM Research Center for Molecular Medicine
362 schema:name CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
363 rdf:type schema:Organization
364 https://www.grid.ac/institutes/grid.430814.a schema:alternateName Antoni van Leeuwenhoek Hospital
365 schema:name CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
366 Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.7719.8 schema:alternateName Spanish National Cancer Research Centre
369 schema:name Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
370 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...