Amphotericin forms an extramembranous and fungicidal sterol sponge View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-03-30

AUTHORS

Thomas M Anderson, Mary C Clay, Alexander G Cioffi, Katrina A Diaz, Grant S Hisao, Marcus D Tuttle, Andrew J Nieuwkoop, Gemma Comellas, Nashrah Maryum, Shu Wang, Brice E Uno, Erin L Wildeman, Tamir Gonen, Chad M Rienstra, Martin D Burke

ABSTRACT

NMR structural data and biophysical and biological experiments show that the antifungal compound amphotericin is toxic because it acts as a sterol sponge by interacting with ergosterol on the fungal membrane and extracting it from within the membrane to the surface of the membrane.

PAGES

400-406

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio.1496

DOI

http://dx.doi.org/10.1038/nchembio.1496

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049690615

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24681535


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