A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12-06

AUTHORS

Jianzhao Liu, Yanan Yue, Dali Han, Xiao Wang, Ye Fu, Liang Zhang, Guifang Jia, Miao Yu, Zhike Lu, Xin Deng, Qing Dai, Weizhong Chen, Chuan He

ABSTRACT

Certain adenosine residues within mammalian RNAs undergo reversible N6 methylation. Two methyltransferase enzymes, METTL3 and METTL14, as well as the splicing factor WTAP are identified as core components of the multiprotein complex that deposits RNA N6-methyladenosine (m6A) in nuclear RNAs.

PAGES

93-95

Journal

TITLE

Nature Chemical Biology

ISSUE

2

VOLUME

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nchembio.1432

DOI

http://dx.doi.org/10.1038/nchembio.1432

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24316715


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