Immune modulation by multifaceted cationic host defense (antimicrobial) peptides View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12

AUTHORS

Ashley L Hilchie, Kelli Wuerth, Robert E W Hancock

ABSTRACT

Cationic host defense (antimicrobial) peptides were originally studied for their direct antimicrobial activities. They have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models. These biological properties suggest that host defense peptides, and synthetic derivatives thereof, possess clinical potential beyond the treatment of antibiotic-resistant infections. In this Review, we provide an overview of the biological activities of host defense and synthetic peptides, their mechanism(s) of action and new therapeutic applications and challenges that are associated with their clinical use. More... »

PAGES

761-768

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nchembio.1393

    DOI

    http://dx.doi.org/10.1038/nchembio.1393

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025315206

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24231617


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